Cerebrospinal fluid pressure dynamics as a biomechanical marker for quantification of spinal cord compression: conceptual framework and systematic review of clinical trials
Brain and Spine,
Год журнала:
2025,
Номер
5, С. 104211 - 104211
Опубликована: Янв. 1, 2025
In
patients
with
acute
spinal
cord
injury
(SCI)
and
degenerative
cervical
myelopathy
(DCM),
compression
is
considered
a
main
contributor
to
damage,
associated
cerebrospinal
fluid
(CSF)
space
obstruction.
CSF
pressure
(CSFP)
dynamics
are
studied
as
potential
indirect
biomechanical
marker
for
compression,
proxy
estimate
perfusion
(SCPP).
Evidence
safety
feasibility
of
CSFP
in
clinical
trials
well
interrelations
neuroimaging
intraspinal
pressure,
relation
preclinical
models.
Systematic
review.
This
review
followed
PRISMA
guidelines,
risk
bias
assessment
ROBINS-I
tool,
PROSPERO
registration
(CRD42024545629).
11
relevant
papers
were
identified
(n
=
212
patients,
n
194
intraoperative,
18
bedside).
Risk
reporting
was
low-moderate.
Intraoperative
assessments
commonly
performed
SCI.
assessed
calculate
SCPP
(7/11),
evaluate
effects
from
surgical
decompression
(5/11)
therapeutic
drainage
(3/11).
The
adverse
event
rate
the
intrathecal
catheter
8%
15/194).
preliminary
profile
encourages
application.
However,
deeper
risk-benefit
analysis
limited
value
not
yet
determined,
given
challenges
defining
disease
specific
critical
thresholds.
interrelation
between
measures
be
proven.
Targeted
studies
essential
improve
our
understanding
complex
CSFP-cord
interrelations.
Язык: Английский
Advection versus diffusion in brain ventricular transport
Опубликована: Апрель 15, 2025
Abstract
Cerebrospinal
fluid
(CSF)
is
integral
to
brain
function.
CSF
provides
mechanical
support
for
the
and
helps
distribute
nutrients,
neurotransmitters
metabolites
throughout
central
nervous
system.
flow
driven
by
several
processes,
including
beating
of
motile
cilia
located
on
walls
ventricles.
Despite
physiological
importance
CSF,
underlying
mechanisms
solute
transport
in
ventricles
remain
be
comprehensively
resolved.
This
study
analyzes
evaluates
specifically
role
transport.
We
developed
finite
element
methods
modeling
using
geometry
zebrafish
larval
ventricles,
which
we
have
detailed
knowledge
properties
motion.
The
computational
model
validated
vivo
experiments
that
monitor
a
photoconvertible
protein
secreted
Our
results
show
while
contribute
advection
large
particles,
diffusion
plays
significant
small
solutes.
also
demonstrate
how
location
ventricular
system
impact
distribution.
Altogether,
this
work
presents
framework
can
applied
other
systems,
together
with
new
concepts
molecules
are
transported
within
its
Язык: Английский