Dynamic Changes of Serotonin Transporter Expression in the Prefrontal Cortex Evoked by Aggressive Social Interactions DOI Creative Commons
Huba Szebik, Christina Miskolczi, Bíborka Bruzsik

и другие.

Neurobiology of Stress, Год журнала: 2025, Номер unknown, С. 100722 - 100722

Опубликована: Март 1, 2025

Aggression is a complex behavior influenced by developmental experiences, internal state, and social context, yet its neurobiological underpinnings remain insufficiently understood. The serotonergic system, particularly the serotonin transporter (SERT), plays crucial role in aggression regulation. Here, we investigated region-specific, dynamic changes SERT expression following aggressive interactions mice subjected to early-life adversity. We found that encounters (resident-intruder test) triggered significant, rapid increase immunoreactivity within 90 min, accompanied neuronal activation aggression-related brain regions, including medial prefrontal cortex (mPFC), lateral septum (LS), amygdala (MeA), ventromedial hypothalamus (VMHvl), habenula (LH), dorsal raphe (DR), but not paraventricular thalamus (PVT). Notably, this upregulation occurred across circuitry was significant 5-HT levels only mPFC, key region top-down regulation of behavior. This observed exposure non-social challenge, suggesting it may be more specifically associated with contexts. Using super-resolution microscopy, identified an increased density localization points mPFC axons after encounter. Social isolation during adolescence, model early neglect, impaired response, ventral orbitofrontal altered relationship between behaviors. These findings demonstrate undergoes rapid, experience-dependent plasticity response aggression, adversity disrupts adaptive mechanism, providing new insights into potential relevance for stress-related dysfunctions.

Язык: Английский

Dynamic Changes of Serotonin Transporter Expression in the Prefrontal Cortex Evoked by Aggressive Social Interactions DOI Creative Commons
Huba Szebik, Christina Miskolczi, Bíborka Bruzsik

и другие.

Neurobiology of Stress, Год журнала: 2025, Номер unknown, С. 100722 - 100722

Опубликована: Март 1, 2025

Aggression is a complex behavior influenced by developmental experiences, internal state, and social context, yet its neurobiological underpinnings remain insufficiently understood. The serotonergic system, particularly the serotonin transporter (SERT), plays crucial role in aggression regulation. Here, we investigated region-specific, dynamic changes SERT expression following aggressive interactions mice subjected to early-life adversity. We found that encounters (resident-intruder test) triggered significant, rapid increase immunoreactivity within 90 min, accompanied neuronal activation aggression-related brain regions, including medial prefrontal cortex (mPFC), lateral septum (LS), amygdala (MeA), ventromedial hypothalamus (VMHvl), habenula (LH), dorsal raphe (DR), but not paraventricular thalamus (PVT). Notably, this upregulation occurred across circuitry was significant 5-HT levels only mPFC, key region top-down regulation of behavior. This observed exposure non-social challenge, suggesting it may be more specifically associated with contexts. Using super-resolution microscopy, identified an increased density localization points mPFC axons after encounter. Social isolation during adolescence, model early neglect, impaired response, ventral orbitofrontal altered relationship between behaviors. These findings demonstrate undergoes rapid, experience-dependent plasticity response aggression, adversity disrupts adaptive mechanism, providing new insights into potential relevance for stress-related dysfunctions.

Язык: Английский

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