Up-regulated programmed cell death protein-1/its ligand 1 expression promotes metabolic dysfunction-associated steatotic liver disease malignant progression DOI Open Access
Min Xu,

Tian-Tian Ruan,

Hao Tang

и другие.

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(5)

Опубликована: Май 15, 2025

This editorial focuses on the recent article by Yang et al in World Journal of Gastrointestinal Oncology , which highlights role interlukin-17A promoting hepatocellular carcinoma (HCC) progression up-regulated programmed cell death protein-1 (PD-1)/programmed protein ligand-1 (PD-L1) expression. Previous, high PD-1/PD-L1 level was due to hepatitis virus infection leading systemic innate immune tolerance and cluster differentiation 8 + T cells exhaustion, ultimately HCC. Recently, interesting studies have found that malignant metabolic dysfunction-associated steatotic/fatty liver disease (MASLD/MAFLD), is former nonalcoholic fatty disease, achieved PD-L1 activated cGAS-STING pathway under lipid accumulation with mitochondrial DNA overflow promote MASLD transformation via escape. These data suggested PD-1 or should be a promising target for preventing delaying non-viral except antiviral therapy

Язык: Английский

Circulating Asprosin and Neuregulin-4 in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review and Meta-analysis DOI Creative Commons
Roshan Kumar Mahat,

Vedika Rathore

Clinical Epidemiology and Global Health, Год журнала: 2025, Номер unknown, С. 102041 - 102041

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Up-regulated programmed cell death protein-1/its ligand 1 expression promotes metabolic dysfunction-associated steatotic liver disease malignant progression DOI Open Access
Min Xu,

Tian-Tian Ruan,

Hao Tang

и другие.

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(5)

Опубликована: Май 15, 2025

This editorial focuses on the recent article by Yang et al in World Journal of Gastrointestinal Oncology , which highlights role interlukin-17A promoting hepatocellular carcinoma (HCC) progression up-regulated programmed cell death protein-1 (PD-1)/programmed protein ligand-1 (PD-L1) expression. Previous, high PD-1/PD-L1 level was due to hepatitis virus infection leading systemic innate immune tolerance and cluster differentiation 8 + T cells exhaustion, ultimately HCC. Recently, interesting studies have found that malignant metabolic dysfunction-associated steatotic/fatty liver disease (MASLD/MAFLD), is former nonalcoholic fatty disease, achieved PD-L1 activated cGAS-STING pathway under lipid accumulation with mitochondrial DNA overflow promote MASLD transformation via escape. These data suggested PD-1 or should be a promising target for preventing delaying non-viral except antiviral therapy

Язык: Английский

Процитировано

0