Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway DOI
Yan Chang,

Biyan He,

Chenjun Wang

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Апрель 16, 2025

Methionine, an essential sulfur-containing amino acid, plays a critical role in methyl metabolism, folate polyamine synthesis, redox homeostasis maintenance, epigenetic modification and signaling pathway regulation, particularly during embryonic development. Animal human studies have increasingly documented that methionine deficiency or excess can negatively impact metabolic processes, translation, epigenetics, pathways, with ultimate detrimental effects on pregnancy outcomes. However, the underlying mechanisms by which precisely regulates modifications affects pathways remain to be elucidated. In this review, we discuss metabolism of its metabolites, influence folate-mediated carbon reactions, DNA RNA methylation, histone modifications, as well mammalian rapamycin complex silent information regulator 1-MYC pathway. This review also summarizes our present understanding contribution these current nutritional pharmaceutical strategies for prevention treatment developmental defects embryos.

Язык: Английский

Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway DOI
Yan Chang,

Biyan He,

Chenjun Wang

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Апрель 16, 2025

Methionine, an essential sulfur-containing amino acid, plays a critical role in methyl metabolism, folate polyamine synthesis, redox homeostasis maintenance, epigenetic modification and signaling pathway regulation, particularly during embryonic development. Animal human studies have increasingly documented that methionine deficiency or excess can negatively impact metabolic processes, translation, epigenetics, pathways, with ultimate detrimental effects on pregnancy outcomes. However, the underlying mechanisms by which precisely regulates modifications affects pathways remain to be elucidated. In this review, we discuss metabolism of its metabolites, influence folate-mediated carbon reactions, DNA RNA methylation, histone modifications, as well mammalian rapamycin complex silent information regulator 1-MYC pathway. This review also summarizes our present understanding contribution these current nutritional pharmaceutical strategies for prevention treatment developmental defects embryos.

Язык: Английский

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