RBMS1-HSPA8 axis activation drives head and neck squamous cell carcinoma progression

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Март 27, 2025

Head and Neck Squamous Cell Carcinoma (HNSCC) presents significant challenges in terms of treatment prognosis, highlighting the urgent need for new therapeutic targets development effective targeted therapies to enhance patient outcomes survival. The expression level RBMS1 HNSCC was identified by GEO TCGA databases through systematic bioinformatics analysis, further verified human specimens quantitative Real-time PCR, Western blot, immunohistochemistry. results CCK-8, colony formation assay, wound healing, Transwell, tumor assays nude mice showed that promoted proliferation, migration, invasion cells. downstream target genes were knockdown control groups TU177 cells using RNA sequencing. HSPA8 as a gene functional vitro experiments mice. Elevated levels relevant validated specimens. In both vivo studies, overexpression cells, whereas significantly inhibited these processes. sequencing analysis revealed RBMS1, rescue confirmed serves crucial intermediary regulatory pathway progression influenced RBMS1. This study suggests regulates promote making it potential HNSCC.

Язык: Английский

Morusin ameliorates tubulointerstitial damage in diabetic mice through SIRT1/HIF-1α/IL-16 signaling pathway

Phytomedicine, Год журнала: 2025, Номер 142, С. 156781 - 156781

Опубликована: Апрель 18, 2025

Язык: Английский