Lactylation: A Novel Epigenetic Regulator of Cellular Senescence DOI Creative Commons
Caiyu Sun, Jiaxuan Li, Lei Dong

и другие.

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related

Язык: Английский

The role of nuclear factor-Y (NF-Y) transcription factor in plant growth and development DOI

Jiayi Hong,

Xiaofeng Feng, Yongping Cai

и другие.

Functional Plant Biology, Год журнала: 2025, Номер 52(4)

Опубликована: Март 26, 2025

The nuclear factor-Y (NF-Y) transcription factor, also known as heme-activator protein (HAP) or CCAAT-binding factor (CBF), is a critical widely present in eukaryotes. number of NF-Y subunits has significantly increased higher plants compared to animals and fungi. complex composed three subunits: (1) NF-YA; (2) NF-YB; (3) NF-YC. NF-YB NF-YC contain histone fold domains (HFDs), which can interact with NF-YA other factors, directly bind the promoter CCAAT box regulate downstream genes. plays significant role various plant processes, including growth development. This review elucidates structural functional aspects subunits, identified complexes, their molecular regulatory mechanisms. Understanding these facets provides valuable insights into advancing crop genetic improvement promoting sustainable agricultural practices.

Язык: Английский

Процитировано

0

Lactylation: A Novel Epigenetic Regulator of Cellular Senescence DOI Creative Commons
Caiyu Sun, Jiaxuan Li, Lei Dong

и другие.

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related

Язык: Английский

Процитировано

0