Cancers,
Год журнала:
2024,
Номер
16(23), С. 3988 - 3988
Опубликована: Ноя. 28, 2024
Background/Objectives:
Patients
with
advanced
cancer
often
present
to
the
emergency
department
(ED)
pain
and
distressing
symptoms
that
are
not
systematically
evaluated.
The
current
study
investigated
association
of
symptom
severity
diagnosis
delirium
short-term
survival.
Methods:
In
this
secondary
analysis
a
prospective
randomized
among
patients
in
ED,
which
were
assessed
by
MD
Anderson
Symptom
Inventory
(MDASI),
we
analyzed
distribution
MDASI
item
scores
90-day
mortality
(Kolmogorov–Smirnov),
(logistic
regression
models),
those
or
without
(Mann–Whitney
U
test
chi-square
test).
Results:
Of
243
included,
222
(91.4%)
had
complete
scores.
median
for
pain,
fatigue,
interference
work
highest.
A
significant
difference
score
was
observed
fatigue
(p
=
0.018),
shortness
breath
<
0.001),
difficulty
remembering
0.038),
lack
appetite
0.035),
drowsiness
feeling
sad
0.031),
walking
0.001).
multivariable
logistic
models,
(adjusted
OR
1.15,
95%
CI
1.04–1.26,
p
0.005)
1.17,
1.05–1.33,
0.008)
associated
mortality,
adjusting
age,
race,
performance
status,
type.
total
significantly
higher
than
(88,
IQR
83–118
vs.
80,
55–104;
Conclusions:
presenting
ED
severe
symptoms,
some
shorter
These
findings
underscore
necessity
systematic
assessment,
focusing
on
breath,
drowsiness,
remembering,
appetite,
sad,
distressed,
enhance
clinical
decision-making
improve
care
cancer.
Additional
longitudinal
studies
needed
evaluate
improvement
quality
life
these
patients.
Emergency Medicine Australasia,
Год журнала:
2025,
Номер
37(1)
Опубликована: Фев. 1, 2025
Abstract
Objective
To
assess
potential
feasibility
of
a
targeted
music
intervention
trial
in
older
ED
patients
and
association
with
clinical
outcomes.
Methods
Prospective
pragmatic
adults
aged
≥65
years
the
ED,
prevalent
delirium
or
increased
risk
incident
delirium,
receiving
either
2‐h
via
headphones
usual
care.
The
primary
outcomes
were
(i)
as
assessed
by
actual
use
(target
70%
offered
patients)
(ii)
delirium‐free
patients.
Results
Among
211
initially
screened
patients,
44
included.
planned
randomised
controlled
proved
difficult
due
to
poor
adherence,
resulting
move
patient
self‐selection
routine
care
intervention.
There
19
control
(13
delirium)
25
participants
(20
delirium);
target
duration
was
achieved
17/25
(68%)
(8/25
achieving
<2
h).
those
without
occurred
1/6
4/5
(
P
=
0.08).
no
between‐group
differences
terms
improved
resolved
pain
scores
agitation/sedation
(all
>
0.1).
Conclusions
Self‐selected
feasible
cohort
While
we
likely
underpowered
detect
associations
between
outcome,
collection
selected
outcome
measures
feasible;
these
may
be
helpful
larger
scale
studies.
Exploration
barriers
facilitators
use,
well
preferred
delivery
methods,
are
wider
investigations
therapy
this
high‐risk
cohort.
Abstract
Introduction
Approximately
2
million
people
in
Italy
are
currently
living
with
dementia
or
mild
cognitive
impairment
(MCI),
and
4
involved
as
family
members
caregivers.
Considering
the
significant
impact
of
dementia,
Italian
Ministry
Health
entrusted
National
Institute
(Istituto
Superiore
di
Sanità)
development
a
guideline
within
Guideline
System
(Sistema
Nazionale
Linee
Guida,
SNLG)
on
diagnosis
treatment
MCI.
The
main
objective
was
to
provide
evidence-based
recommendations
aimed
at
reducing
variability
ensuring
appropriateness
clinical
practices
throughout
whole
care
process
from
identification
end
life
for
(PwD)
MCI
their
families/caregivers.
Methods
GRADE-ADOLOPMENT
approach
used
adopt,
adapt
update
developed
by
Care
Excellence
2018
(NG97).
methodology
based
Methodological
Handbook
produced
SNLG.
A
multidisciplinary
panel
29
experts
four
representatives
members/caregivers
discussed
approved
47
review
questions.
Of
these,
34
questions
were
adopted
NG97,
13
new
questions,
including
10
referring
Systematic
literature
reviews
performed
each
question,
team
methodological
qualitatively
assessed
summarised
results
included
studies
GRADE
approach.
To
facilitate
implementation
dissemination
contents
this
guideline,
pathway
leaflet
dedicated
PwD
families/caregivers
also
developed.
Results
published
up
November
2023.
More
than
1000
peer-reviewed
publications
included,
covering
following
areas:
(i)
identification,
post-diagnostic
support;
(ii)
models
coordination;
(iii)
pharmacological
interventions
symptoms;
(iv)
non-pharmacological
(v)
non-cognitive
symptoms,
intercurrent
illnesses
palliative
care.
167
practice
39
research
recommendations.
Commentary
Italy’s
first
addresses
diagnosis,
Healthcare
System.
It
includes
approaches,
emphasises
tailored
interventions,
comprehensive
assessment,
staff
training
underlines
need
involve
decision-making
supporting
caregivers
entire
course
disease.
Conclusions
Structured
strategies
will
be
defined
Fund
Alzheimer
other
Dementias
2024–2026.
An
interactive
carers
already
available.
updated
starting
January
2027,
but
early
updates
may
planned
case
breakthrough
advancements.
European Journal of Case Reports in Internal Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
We
report
the
case
of
a
75-year-old
woman
admitted
to
emergency
department
for
confusion,
gait
disturbances
and
mutism
associated
with
an
inflammatory
syndrome
occurring
3
weeks
after
acute
carbon
monoxide
intoxication.
The
main
hypothesis
upon
arrival
was
infectious
meningoencephalitis,
patient
put
on
acyclovir
antibiotics
in
meningeal
doses.
After
short
stay
intensive
care,
patient's
condition
did
not
improve,
revaluation
her
history
imaging
studies
led
diagnosis
post-interval
secondary
intoxication
3-week
asymptomatic
period.
Post-interval
is
complication
poorly
known
clinicians,
manifesting
as
neuropsychiatric
disorders
despite
initial
period
improvement.
Repeated
magnetic
resonance
imaging,
conjunction
compatible
clinical
findings,
allow
be
made.
No
neurological
improved
noted
6
months
follow-up.
little-known
clinicians
should
considered
any
presenting
symptom-free
interval
following
intoxication.Repeated
at
distance
from
onset
(more
than
month)
helps
distinguish
it
cytotoxic
oedema
which
may
initially
confused.The
prognosis
poor
no
proven
effective
treatment
date.
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(4)
Опубликована: Апрель 1, 2025
Abstract
INTRODUCTION
Cognitive
impairment
(CI)
is
under‐recognized
by
emergency
department
(ED)
clinicians,
and
processes
for
cognitive
screening
outpatient
referrals
are
limited.
METHODS
This
pilot
study
tested
the
feasibility
of
ED
clinicians
referring
older
adult
patients
identified
through
CI
direct
clinician
referral
evaluation.
Telephone
interviews
chart
reviews
were
conducted
on
100
about
their
care,
function,
status.
RESULTS
A
total
9359
screened
memory
thinking
problems,
with
650
(6.9%)
reporting
such
issues.
discharged
referred
evaluation,
consisting
37
from
67
referral.
Of
these,
26
(26.0%)
scheduled
19
(19.0%)
completed
evaluations
within
days.
Fifteen
(78.9%)
formally
diagnosed
dementia,
CI,
or
loss.
DISCUSSION
able
to
identify
appropriately
refer
Future
studies
can
improve
rates
solutions
addressing
detection
follow‐up
challenges.
Highlights
Screening
evaluation
feasible
in
department.
Nearly
80%
who
impairment,
including
probable
dementia
Alzheimer's
disease.
Significant
gaps
barriers
remain
maintaining
initial
department,
less
than
one
five
completing
evaluations.
Academic Emergency Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 7, 2024
Abstract
Objective
As
part
of
the
Geriatric
Emergency
Department
(ED)
Guidelines
2.0
project,
we
conducted
a
systematic
review
to
find
risk
factors
or
stratification
approaches
that
can
be
used
identify
subsets
older
adults
who
may
benefit
from
targeted
ED
delirium
screening.
Methods
An
electronic
search
strategy
was
developed
with
medical
librarian,
in
April
2021
and
November
2022.
Full‐text
studies
patients
≥65
years
assessed
for
prevalent
were
included.
Risk
bias
using
McMaster
University
Clarity
Group
tool.
Outcomes
measures
pertained
method
used.
Due
heterogeneity
patient
populations,
methods,
outcomes,
meta‐analysis
not
conducted.
Results
Our
yielded
1878
unique
citations,
which
13
Six
novel
score
without
evaluation
specific
factors,
six
evaluated
only,
one
study
an
existing
nondelirium
association
delirium.
The
most
common
factor
history
dementia,
odds
ratios
ranging
3.3
(95%
confidence
interval
[CI]
1.2–8.9)
18.33
CI
8.08–43.64).
Other
consistently
associated
increased
included
age,
use
certain
medications
(such
as
antipsychotics,
antidepressants,
opioids,
among
others),
functional
impairments.
Of
scores,
reported
area
under
curve
ranged
0.77
0.90.
Only
two
potential
impact
tool
on
screening
burden.
Conclusions
There
is
significant
heterogeneity,
but
results
suggest
such
age
over
75,
impairments
should
are
at
highest
No
implementation
patient‐oriented
outcomes.
World Journal of Psychiatry,
Год журнала:
2024,
Номер
14(7), С. 1027 - 1033
Опубликована: Июль 11, 2024
BACKGROUND
Delirium
is
a
neuropsychiatric
syndrome
characterized
by
acute
disturbances
of
consciousness
with
rapid
onset,
progression,
obvious
fluctuations,
and
preventable,
reversible,
other
characteristics.
Patients
delirium
in
the
intensive
care
unit
(ICU)
are
often
missed
or
misdiagnosed
do
not
receive
adequate
attention.
AIM
To
analyze
risk
factors
for
ICU
patients
explore
application
emotional
nursing
pain
management
delirium.
METHODS
General
data
301
critically
ill
were
retrospectively
collected,
including
histories
(cardiovascular
cerebrovascular
diseases,
hypertension,
smoking,
alcoholism,
diabetes),
age,
sex,
diagnosis,
whether
surgery
was
performed,
patient
origin
(emergency/clinic).
Additionally,
duration
sedation,
Richmond
Agitation
Sedation
Scale
score,
combined
care,
ventilator
use
duration,
vasoactive
drug
use,
drainage
tube
retention,
stay
C-reactive
protein,
procalcitonin,
white
blood
cell
count,
body
temperature,
Acute
Physiology
Chronic
Health
Evaluation
II
(APACHE
II)
Sequential
Organ
Failure
Assessment
score
recorded
within
24
h
after
admission.
assessed
according
to
confusion
assessment
method
ICU,
univariate
multivariate
logistic
regression
analyses
performed
identify
patients.
RESULTS
Univariate
analysis
on
potential
associated
The
results
showed
that
16
closely
related
delirium,
history
diabetes,
origin.
Multivariate
revealed
no
emergency
source,
surgery,
long
smoking
history,
high
APACHE
independent
CONCLUSION
diabetes
and/or
postoperative
patients,
those
admission
need
flexible
visiting
modes,
early
intervention
reduce
incidence.
Nursing in Critical Care,
Год журнала:
2024,
Номер
29(6), С. 1215 - 1223
Опубликована: Авг. 13, 2024
Delirium
is
a
common
acute
mental
disorder,
and
its
adverse
outcomes
often
cause
distress
to
both
patients
their
families.
Despite
prevalence
in
treated
emergency
departments,
delirium
frequently
overlooked.
Journal of the American College of Emergency Physicians Open,
Год журнала:
2024,
Номер
5(3)
Опубликована: Май 8, 2024
Abstract
Healthcare
systems
face
significant
challenges
in
meeting
the
unique
needs
of
older
adults,
particularly
acute
setting.
Age‐friendly
healthcare
is
a
comprehensive
approach
using
4Ms
framework—what
matters,
medications,
mentation,
and
mobility—to
ensure
that
settings
are
responsive
to
patients.
The
Age‐Friendly
Emergency
Department
(AFED)
crucial
component
holistic
age‐friendly
health
system.
Our
objective
provide
an
overview
AFED
model,
its
core
principles,
benefits
adults
clinicians.
optimizes
delivery
emergency
care
by
integrating
age‐specific
considerations
into
various
aspects
(1)
ED
physical
infrastructure,
(2)
clinical
policies,
(3)
transitions.
Physical
infrastructure
incorporates
environmental
modifications
enhance
patient
safety,
including
adequate
lighting,
nonslip
flooring,
devices
for
sensory
ambulatory
impairment.
Clinical
policies
address
physiological,
cognitive,
psychosocial
while
preserving
focus
on
issues.
Care
transitions
include
communication
involving
community
partners
case
management
services.
prioritizes
collaboration
between
interdisciplinary
team
members
(ED
clinicians,
geriatric
specialists,
nurses,
physical/occupational
therapists,
social
workers).
By
adopting
approach,
EDs
have
potential
improve
patient‐centered
outcomes,
reduce
adverse
events
hospitalizations,
functional
recovery.
Moreover,
clinicians
benefit
from
model
through
increased
satisfaction,
multidisciplinary
support,
enhanced
training
care.
Policymakers,
administrators,
must
collaborate
standardize
guidelines,
barriers
AFEDs,
promote
adoption
practices
ED.