Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2220 - 2220
Опубликована: Июль 11, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
common
long-lasting
that
affects
millions
of
people
around
the
world.
It
best
identified
with
hepatic
fat
build-up
ultimately
leads
to
inflammation
and
damage.
The
classification
nomenclature
NAFLD
have
long
been
controversial
topic,
until
2020
when
group
international
experts
recommended
substituting
MAFLD
(metabolic
dysfunction-associated
FLD).
was
then
terminologically
complemented
in
2023
by
altering
it
MASLD,
i.e.,
metabolic
steatotic
(MASLD).
Both
MASLD
terminologies
comprise
element
disorder,
as
they
offer
diagnostic
benchmarks
are
embedded
risk
factors
underlie
disease.
(as
multisystemic
disease)
provides
comprehensive
definition
includes
larger
population
patients
who
at
morbidity
mortality,
well
adverse
cardiovascular
diabetes
outcomes.
highlights
risks
lean
or
normal
weight
individuals,
factor
has
not
accentuated
discussed
previous
guidelines.
Novel
antihyperglycemic
agents,
anti-hyperlipidemic
drugs,
lifestyle
modifications,
nutritional
interventions,
exercise
therapies
extensively
studied
MASLD.
Nutrition
plays
vital
role
managing
both
conditions,
where
centralizing
on
diet
rich
whole
vegetables,
fruits,
foods,
healthy
fats,
proteins,
specific
nutrients
(e.g.,
omega-3
acids
fibers)
can
improve
insulin
resistance
reduce
inflammation.
Thus,
essential
understand
nutrition
these
conditions
work
develop
an
individualized
plan
for
optimal
health.
This
review
discusses
prevention
strategies
NAFLD/MAFLD/MASLD
management,
particular
attention
correction.
Nutrients,
Год журнала:
2023,
Номер
15(12), С. 2749 - 2749
Опубликована: Июнь 14, 2023
The
Western
diet
is
a
modern
dietary
pattern
characterized
by
high
intakes
of
pre-packaged
foods,
refined
grains,
red
meat,
processed
high-sugar
drinks,
candy,
sweets,
fried
conventionally
raised
animal
products,
high-fat
dairy
and
high-fructose
products.
present
review
aims
to
describe
the
effect
on
metabolism,
inflammation,
antioxidant
status;
impact
gut
microbiota
mitochondrial
fitness;
cardiovascular
health,
mental
cancer;
sanitary
cost
diet.
To
achieve
this
goal,
consensus
critical
was
conducted
using
primary
sources,
such
as
scientific
articles,
secondary
including
bibliographic
indexes,
databases,
web
pages.
Scopus,
Embase,
Science
Direct,
Sports
Discuss,
ResearchGate,
Web
were
used
complete
assignment.
MeSH-compliant
keywords
“Western
diet”,
“inflammation”,
“metabolic
health”,
fitness”,
“heart
disease”,
“cancer”,
“oxidative
stress”,
“mental
“metabolism”
used.
following
exclusion
criteria
applied:
(i)
studies
with
inappropriate
or
irrelevant
topics,
not
germane
review’s
focus;
(ii)
Ph.D.
dissertations,
proceedings
conferences,
unpublished
studies.
This
information
will
allow
for
better
comprehension
nutritional
behavior
its
an
individual’s
metabolism
well
national
systems.
Finally,
practical
applications
derived
from
are
made.
Clinical and Molecular Hepatology,
Год журнала:
2022,
Номер
29(Suppl), С. S17 - S31
Опубликована: Ноя. 29, 2022
“Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)”
is
the
term
suggested
in
2020
to
refer
related
systemic
metabolic
dysregulation.
The
name
change
from
nonalcoholic
(NAFLD)
MAFLD
comes
with
a
simple
set
of
criteria
enable
easy
diagnosis
at
bedside
for
general
medical
community,
including
primary
care
physicians.
Since
introduction
term,
there
have
been
key
areas
which
superiority
over
traditional
NAFLD
terminology
has
demonstrated,
risk
and
extrahepatic
mortality,
associations,
identifying
high-risk
individuals.
Additionally,
adopted
by
number
leading
pan-national
national
societies
due
its
concise
diagnostic
criterion,
removal
requirement
exclude
concomitant
diseases,
reduction
stigma
associated
this
condition.
current
article
explores
differences
between
diagnosis,
benefit,
some
potential
limitations,
how
opened
up
new
fields
research.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Авг. 13, 2022
Non-alcohol-associated
fatty
liver/steatohepatitis
(NAFL/NASH)
has
become
the
leading
cause
of
liver
disease
worldwide.
NASH,
an
advanced
form
NAFL,
can
be
progressive
and
more
susceptible
to
developing
cirrhosis
hepatocellular
carcinoma.
Currently,
lifestyle
interventions
are
most
essential
effective
strategies
for
preventing
controlling
NAFL
without
development
fibrosis.
While
there
still
limited
appropriate
drugs
specifically
treat
NAFL/NASH,
growing
progress
is
being
seen
in
elucidating
pathogenesis
identifying
therapeutic
targets.
In
this
review,
we
discussed
recent
developments
etiology
prospective
targets,
as
well
pharmacological
candidates
pre/clinical
trials
patents,
with
a
focus
on
diabetes,
hepatic
lipid
metabolism,
inflammation,
Importantly,
evidence
elucidates
that
disruption
gut-liver
axis
microbe-derived
metabolites
drive
NAFL/NASH.
Extracellular
vesicles
(EVs)
act
signaling
mediator,
resulting
accumulation,
macrophage
stellate
cell
activation,
further
promoting
inflammation
fibrosis
progression
during
Targeting
gut
microbiota
or
EVs
may
serve
new
treatment
Finally,
other
mechanisms,
such
therapy
genetic
approaches,
also
have
enormous
potential.
Incorporating
different
mechanisms
personalized
medicine
improve
efficacy
better
benefit
patients
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2022,
Номер
107(9), С. 2691 - 2700
Опубликована: Май 19, 2022
Abstract
Background
and
Aims
Metabolic-associated
fatty
liver
disease
(MAFLD)
was
proposed
as
a
better
definition
of
nonalcoholic
(NAFLD)
to
encompass
the
metabolic
dysregulation
associated
with
NAFLD.
This
redefinition
challenges
our
understanding
disease.
Hence,
this
study
sought
conduct
an
updated
analysis
prevalence,
clinical
characteristics,
factors
MAFLD,
further
sensitivity
done
based
on
lean
nonobese
MAFLD
individuals.
Methods
Medline
Embase
databases
were
searched
include
articles
MAFLD.
Meta-analysis
proportions
conducted
using
generalized
linear
mix
model.
Associating
evaluated
in
conventional
pairwise
meta-analysis
Results
From
pooled
involving
3
320
108
individuals,
overall
prevalence
38.77%
(95%
CI
32.94%
44.95%);
5.37%
4.36%
6.59%)
29.78%
26.06%
33.79%)
respectively,
had
Metabolic
complications
such
hypertension
[odds
ratio
(OR)
2.63,
95%
1.85
3.74,
P
<
0.0001
OR
2.03;
1.74
2.38,
0.0001,
respectively]
diabetes
(OR
3.80,
2.65
5.43,
3.46,
2.81
4.27,
respectively)
found
significant
associating
Conclusions
supports
previous
studies
reporting
affect
more
than
third
global
population.
While
exploration
pathogenic
basis
without
is
required,
emphasis
management
concomitant
can
improve
multidisciplinary
efforts
managing
complex
Hepatology,
Год журнала:
2022,
Номер
77(3), С. 949 - 964
Опубликована: Авг. 16, 2022
Background
and
Aims:
Early
identification
of
modifiable
risk
factors
is
essential
for
the
prevention
nonalcoholic
fatty
liver
disease
(NAFLD).
We
aimed
to
systematically
explore
relationships
between
genetically
predicted
NAFLD.
Approach
Results:
applied
univariable
multivariable
Mendelian
randomization
analyses
35
also
evaluated
combined
results
in
three
independent
large
genome‐wide
association
studies.
Genetically
alcohol
frequency,
elevated
serum
levels
enzymes,
triglycerides,
C‐reactive
protein,
obesity
traits,
including
body
mass
index,
waist
circumference,
fat
mass,
were
associated
with
increased
risks
NAFLD
(all
p
<
0.05).
Poor
physical
condition
had
a
suggestive
(odds
ratio
[OR]
=
2.63,
0.042).
instrumented
type
2
diabetes
(T2DM),
hypothyroidism,
hypertension
all
NAFLD,
ORs
(95%
confidence
interval)
1.508
(1.20–1.90),
13.08
(1.53–111.65),
3.11
(1.33–7.31)
1‐U
increase
log‐transformed
odds,
respectively.
The
positive
associations
T2DM
remained
significant
analyses.
from
discovery
two
replication
datasets
further
confirmed
that
poor
condition,
T2DM,
significantly
whereas
higher
education
high‐density
lipoprotein
cholesterol
(HDL‐cholesterol)
could
lower
risk.
Conclusions:
an
HDL‐cholesterol
decreased
