Clinical Characteristics and Outcomes of Small Bowel Neoplasms in Crohn’s Disease: A Case-Control Study DOI Creative Commons
Siri A. Urquhart, Thomas C. Smyrk, William S. Harmsen

и другие.

Crohn s & Colitis 360, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 30, 2024

Patients with Crohn's disease (CD) who have ileal or any small bowel (SB) involvement are at increased risk of developing SB cancer. Due to the rarity this complication CD, we aimed describe clinical features, presentation, and neoplasms (SBN) in patients CD. A case-control study was performed include ≥18 years old a diagnosis CD without SBN single large referral center from January 1992 May 2023. were identified using bioinformatics natural language processing tools, as well anatomic pathology records. Two age- sex-matched controls for each case. In total, 54 108 identified. Of cases, most had (55.6%) stricturing (59.3%) phenotype. Median duration prior 19.5 years. Nonpenetrating/nonstricturing behavior (odds ratio [OR], 9.23; 95% CI, 2.91-29.32; P = .0008) significantly associated an odds SBN. History tobacco use (OR, 0.27; 0.13-0.60; .0011) IBD-associated colonic neoplasia 0.18; 95%, CI 0.4-0.85; .0303) protective development appeared raise risk. reduced Further studies sample sizes needed determine true incidence factors assess potentially effects early surgery.

Язык: Английский

Bi2O2Se nanosheets coated with rosmarinic acid for colon-targeted treatment of inflammatory bowel disease DOI

Jiahu Yao,

Yuan‐Han Yang, Zhao Hu

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160230 - 160230

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Risk of Small Intestine Cancer in Inflammatory Bowel Disease: A Propensity-Matched Study from a Large Multi-Center Database in the United States DOI
Saqr Alsakarneh, Mohamed Ahmed, Samiya Azim

и другие.

The American Journal of Gastroenterology, Год журнала: 2024, Номер 119(11), С. 2334 - 2337

Опубликована: Июль 25, 2024

INTRODUCTION: The risk of small bowel cancer (SBC) in inflammatory disease (IBD) is unclear. We compared the recent trends SBC patients with IBD and stratified them based on type. METHODS: used TriNetX database to access electronic health records for IBD, ulcerative colitis (UC), Crohn's (CD) from 2005 2024. propensity score matching compare rate UC, CD general population. adjusted all known confounders. RESULTS: From 2010 2024, there was an increasing trend diagnosed average annual percentage change 3.2% ( P < 0.001). Patients (adjusted hazard ratio = 4.83; 95% confidence interval: 3.58–6.53; 0.0001) had increased population without as well UC 2.28; 1.65–3.14; 0.0001). ileum most common location across subgroups. DISCUSSION: Both and, interestingly, elevated developing

Язык: Английский

Процитировано

2
Surgical Management of Peritoneal Metastases from Appendix and Colon Cancer in Patients with Inflammatory Bowel Disease DOI Creative Commons
Vladislav Kovalik, Mary Caitlin King, Sergei Iugai

и другие.

Surgical Oncology Insight, Год журнала: 2024, Номер 1(4), С. 100092 - 100092

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

0
Risk of incident cancer in patients with Inflammatory Bowel Disease with prior breast cancer: a multicenter cohort study DOI Creative Commons
Guillaume Le Cosquer, Julien Kirchgesner, Cyrielle Gilletta

и другие.

Clinical Gastroenterology and Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident rate (recurrence or new-onset cancer) a cohort IBD history breast according subsequent treatment provided.

Язык: Английский

Процитировано

0
Clinical Characteristics and Outcomes of Small Bowel Neoplasms in Crohn’s Disease: A Case-Control Study DOI Creative Commons
Siri A. Urquhart, Thomas C. Smyrk, William S. Harmsen

и другие.

Crohn s & Colitis 360, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 30, 2024

Patients with Crohn's disease (CD) who have ileal or any small bowel (SB) involvement are at increased risk of developing SB cancer. Due to the rarity this complication CD, we aimed describe clinical features, presentation, and neoplasms (SBN) in patients CD. A case-control study was performed include ≥18 years old a diagnosis CD without SBN single large referral center from January 1992 May 2023. were identified using bioinformatics natural language processing tools, as well anatomic pathology records. Two age- sex-matched controls for each case. In total, 54 108 identified. Of cases, most had (55.6%) stricturing (59.3%) phenotype. Median duration prior 19.5 years. Nonpenetrating/nonstricturing behavior (odds ratio [OR], 9.23; 95% CI, 2.91-29.32; P = .0008) significantly associated an odds SBN. History tobacco use (OR, 0.27; 0.13-0.60; .0011) IBD-associated colonic neoplasia 0.18; 95%, CI 0.4-0.85; .0303) protective development appeared raise risk. reduced Further studies sample sizes needed determine true incidence factors assess potentially effects early surgery.

Язык: Английский

Процитировано

0