Fermented Kamut Wheat Diet Prevents DSS-Induced Colitis via Modulating Gut Microbiota in Mice

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3017 - 3017

Опубликована: Март 26, 2025

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract with limited treatment options. This study investigates preventive effects fermented Kamut wheat enzyme (FKW) diet on progression dextran sulfate sodium (DSS)-induced colitis in mice, focus gut microbiota modulation cytokine regulation. Female C57BL/6J mice were divided into groups fed consisting either FKW (containing 39.80% FKW) or control under 1.25% 2.50% DSS conditions. The was formulated based AIN-93G standard rodent formula, providing comparable amounts total proteins, crude lipids, dietary fibers as diet. effectively mitigated colitis, evidenced by improvements key indicators such intake, body weight, colon length, stool consistency, bleeding, particularly group. Histopathological analysis revealed preservation colonic architecture reduced mucosal damage also resulted significant reduction pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IFN-γ) myeloperoxidase (MPO) levels, coupled an increase anti-inflammatory IL-10. Gut showed increased abundance beneficial bacteria Muribaculaceae, Lachnospiraceae NK4A136 Bacteroides acidifaciens decreased pathogenic like Escherichia/Shigella Bilophila. These findings underscore potential intervention for mitigating emphasizing role supporting intestinal health. results highlight FKW's to reduce risk development, foundation future research its applications.

Язык: Английский

Prevention and interception trials in inflammatory bowel disease: an international taskforce assessment on clinical trial design

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Introduction to Thirteenth Issue CGH The Future of Inflammatory Bowel Disease Care

Clinical Gastroenterology and Hepatology, Год журнала: 2024, Номер 23(3), С. 383 - 385

Опубликована: Окт. 24, 2024

Язык: Английский