B(C₆F₅)₃-Catalyzed Regioselective Deuteration of Terminal Olefins Using D₂O as the Deuterium Source

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

The selective deuteration of α-alkyl olefins is challenging due to their polymerization tendency and limited catalytic options. Herein, we report the B(C6F5)3-catalyzed terminal using D2O as deuterium source. This approach efficiently achieves hydrogen-deuterium exchange via carbocation intermediates, demonstrating broad substrate scope, including α-methylstyrenes, internal alkenes, heterocycles, natural product derivatives, with high incorporation functional group tolerance. Additionally, optimized conditions enable synthesis fully deuterated oligomeric products, highlighting method's versatility.

Язык: Английский

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Metal-free C–H borylation of heterocycles by merging photoredox and hydrogen atom transfer catalysis

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(17), С. 4785 - 4793

Опубликована: Янв. 1, 2024

Reported herein is a method that merges organophotoredox and hydrogen atom transfer catalysis to enable the C–H borylation of heterocycles using O 2 as an environmentally friendly oxidant.

Язык: Английский

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Synthesis of C5-boryl indoles via a borane-catalyzed cascade

Chem Catalysis, Год журнала: 2024, Номер 4(5), С. 101005 - 101005

Опубликована: Май 1, 2024

Язык: Английский

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