Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging DOI
Rui-Tian Ge,

Feng Xiong,

Zhen‐Bang Chen

и другие.

Chem, Год журнала: 2025, Номер unknown, С. 102489 - 102489

Опубликована: Март 1, 2025

Язык: Английский

Enantioselective Synthesis of Chiral 2,2-Difluoro-spiroindanone-dihydroquinazolinones by CPA-Catalyzed Cyclization Reactions DOI

Xing‐Pin Wei,

Gao Fen,

Dan Li

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

The synthesis of chiral gem-difluorinated spiro-heterocyclic compounds continues to be a significant challenge in organic chemistry due their widespread applications across various fields. Therefore, efficient asymmetric approaches for the spiroindanone-dihydroquinazolinones are particularly valuable, especially industrial manufacturing fluorinated drugs. Herein, we developed CPA-catalyzed enantioselective cyclization reactions gem-difluoroalkyl 1,3-indandiones with anthranilamides achieve 2,2-difluoro-spiroindanone-dihydroquinazolinones good high yields excellent enantioselectivities. Moreover, mechanism experiment proved that gem-difluoro substitution pattern promotes reaction.

Язык: Английский

Процитировано

0
Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging DOI
Rui-Tian Ge,

Feng Xiong,

Zhen‐Bang Chen

и другие.

Chem, Год журнала: 2025, Номер unknown, С. 102489 - 102489

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0