Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Biosensors, Год журнала: 2023, Номер 13(3), С. 333 - 333

Опубликована: Март 1, 2023

With its fatal effects, cancer is still one of the most important diseases today’s world. The underlying fact behind this scenario probably due to late diagnosis. That why necessity for detection different types obvious. Cancer studies including diagnosis and therapy have been laborious tasks. Since early significantly affects following steps, very important. Despite researchers’ best efforts, accurate rapid challenging difficult investigate. It known that electrochemical techniques successfully adapted into field. Electrochemical sensor platforms are brought together with excellent selectivity biosensing elements, such as nucleic acids, aptamers or antibodies, put forth successful outputs. One remarkable achievements these biomolecule-attached sensors their lack need additional labeling which bring extra burdens interference effects demanding modification protocols. In review, we aim outline label-free use methods acquire signals. classification sensing generally presented according recognition element, recent by using attractive substrates described in detail. addition, current challenges discussed.

Язык: Английский

---

2D graphene-based advanced nanoarchitectonics for electrochemical biosensors: Applications in cancer biomarker detection

Biosensors and Bioelectronics, Год журнала: 2024, Номер 250, С. 116050 - 116050

Опубликована: Янв. 24, 2024

Low-cost, rapid, and easy-to-use biosensors for various cancer biomarkers are of utmost importance in detecting early-stage metastasis control efficient diagnosis. The molecular complexity is overwhelming, thus, the repeatability reproducibility measurements by critical factors. Electrochemical attractive alternatives diagnosis due to their low cost, simple operation, promising analytical figures merit. Recently graphene-derived nanostructures have been used extensively fabrication electrochemical because unique physicochemical properties, including high electrical conductivity, adsorption capacity, cost ease mass production, presence oxygen-containing functional groups that facilitate bioreceptor immobilization, increased flexibility mechanical strength, cellular toxicity. Indeed, these properties make them advantageous compared other alternatives. However, some drawbacks must be overcome extend use, such as poor uncontrollable deposition on substrate dispersity graphene materials irreproducibility results differences batches produced materials. This review has documented most recently developed strategies sensor fabrication. It differs categorization method published works draw greater attention wide opportunities nanomaterials biological applications. Limitations future scopes discussed advance integration novel technologies artificial intelligence, internet medical things, triboelectric nanogenerators eventually increase efficacy efficiency.

Язык: Английский

---

Unveiling the future: Breakthroughs and innovations in MXene-based electrochemical sensors

Chemical Engineering Journal, Год журнала: 2025, Номер 507, С. 160392 - 160392

Опубликована: Фев. 16, 2025

Язык: Английский

---

An electrodeposition of Cu-MOF on platinum electrode for efficient electrochemical degradation of tartrazine dye with parameter control and degradation mechanisms: Experimental and theoretical findings

Applied Surface Science Advances, Год журнала: 2024, Номер 19, С. 100577 - 100577

Опубликована: Фев. 1, 2024

Electrochemical oxidation is a low-toxicity, fast-reacting technology that easy to employ. This has great promise for improving the sustainability and efficiency of wastewater treatment by eliminating dyes other organic contaminants. In this study, cathodic electrodeposition technique was used effectively synthesize pure Cu-MOF on Pt electrode. Fourier-Transform Infrared Spectroscopy (FTIR), Ultraviolet -Visible (UV-Vis), Scanning Electron Microscopy (SEM), Energy-Dispersive X-Ray (EDX), Diffraction (XRD) were evaluate synthesized Copper-Metal Organic Framework (Cu-MOF). The electrochemical degradation tartrazine dye in an aqueous KCl solution under various conditions Cu-MOF/Pt Tartrazine (Tz) as function time been adjusted influence operational parameters such type supporting electrolyte, pH solution, accumulation time, applied potential. Based results, acid medium (pH=3) most beneficial active Tz at optimal operating conditions. It found 99 % had disappeared following 20 min electrolysis. potential 1.4 V since it no negative impacts energy consumption or stability durability electrodes. fitted pseudo-first-order kinetics with rate constant 0.124 min-1. findings demonstrated good %, electrode recovery, reproducibility, reusability have all researched. A computational investigation Lee/Yang/Parr (B3LYP) level, 6-311++ G(d,p), basis set calculation demonstrate destruction HClO radical. results showed experimentally predicted mechanism theoretically determined agreed remarkably well. According proposed mechanism, functions catalyst Tz, where discharges water produce HO• radicals, which are physically adsorbed surface. Cu-MOF(HO•) combines Cl− ions presence form Cu-MOF(HClO) attacks azo bond (–N=N–) degrades into CO2 H2O.

Язык: Английский

---

Tungsten oxide thin film field-effect transistor based real-time sensing system for non-invasive oral cancer biomarker detection

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 407, С. 135486 - 135486

Опубликована: Фев. 13, 2024

Язык: Английский

---

High-throughput screening of perovskite-based electrochemical sensor for determination of Piroxicam via electrocatalytic oxidation in pharmaceutical and biomedical analysis

Materials Chemistry and Physics, Год журнала: 2024, Номер 316, С. 129100 - 129100

Опубликована: Фев. 21, 2024

Язык: Английский

---

Two-dimensional nanozyme nanoarchitectonics customized electrochemical bio diagnostics and lab-on-chip devices for biomarker detection

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 341, С. 103474 - 103474

Опубликована: Март 20, 2025

Язык: Английский

---

Recent progress of biosensors for the detection of lung cancer markers

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(25), С. 5715 - 5747

Опубликована: Янв. 1, 2023

This review mainly provides a comprehensive discussion on the detection of lung cancer markers such as miRNA, DNA and proteins using biosensors electrochemical, optical nanopore developed in past 5 years.

Язык: Английский

---

Advancements in biosensors for cancer detection: revolutionizing diagnostics

Medical Oncology, Год журнала: 2024, Номер 41(3)

Опубликована: Фев. 19, 2024

Язык: Английский

---

Synergistic activity of copper and molybdenum based organic frameworks for the exceptional electrochemical detection of rifampicin in commercial dairy products

Microchemical Journal, Год журнала: 2024, Номер 199, С. 110115 - 110115

Опубликована: Фев. 7, 2024

Язык: Английский

---