Contaminants
of
emerging
concern
(CECs)
present
a
new
threat
to
the
marine
environment,
and
it
is
vital
understand
interactions
possible
toxicity
CEC
mixtures
once
they
reach
ocean.
CECs—
such
as
metal
nanoparticles,
nanoplastics
pharmaceuticals—
are
groups
contaminants
some
which
have
been
individually
evaluated,
though
their
still
not
fully
understood.
Reproduction
also
essential
ensure
healthy
prosperous
next
generation,
however,
population
dynamics
may
be
at
danger
if
reproduction
hindered
result
exposure
CECs,
leading
an
negative
impact
on
biodiversity.
This
study
aimed
effects
silver
(20
nm
nAg,
10
µg/L)
polystyrene
nanoparticles
(50
nPS,
µg/L),
well
5-fluorouracil
(5FU,
ng/L)
mixture
(10
µg/L
nPS
+
nAg
ng/L
5FU)
in
gonads
Mytilus
galloprovincialis.
A
multibiomarker
approach,
namely
antioxidant
defence
system
(ADS;
superoxide
dismutase,
catalase,
glutathione
peroxidase,
–
S
transferase
activities),
oxidative
damage
(OD;
lipid
peroxidation)
were
analysed
mussels.
Mussel
ADS
was
overwhelmed
by
reactive
oxygen
species
generated
CECs.
Individual
resulted
OD
all
cases,
but
mussels
exposed
Mix,
increased
57-fold.
When
interact
potentially
more
hazardous
than
individual
components,
so
pose
major
species.
model
applied
data
synergistic
or
antagonistic
interactions.
An
interaction
between
these
CECs
observed,
synergism
encountered
after
3
days
due
OD.
However,
observed
Mix-exposed
mussel
mainly
5FU
nPS.
The Science of The Total Environment,
Год журнала:
2024,
Номер
918, С. 170568 - 170568
Опубликована: Фев. 2, 2024
Among
personal
care
products,
quaternium-15
is
prominently
featured
as
a
preservative
in
items
such
shampoos,
soaps,
shaving
and
cosmetics.
The
widespread
use
of
these
products
people's
daily
routines
contributes
to
release
into
aquatic
ecosystems.
In
this
context,
the
primary
aim
study
was
assess
physiological
cellular
responses
digestive
gland
gills
Mytilus
galloprovincialis
exposure.
Cell
viability
ability
cells
regulate
their
volume
were
evaluated.
Additionally,
expression
genes
involved
oxidative
stress
response
assessed
further
substantiate
compound's
harmful
effects.
Results
indicated
significant
decrease
both
RVD
(regulatory
decrease)
capacity
when
exposed
hypotonic
solution.
Furthermore,
impairment
cell
function
corroborated
by
modulation
stress-related
gene
expression,
including
SOD,
Cat,
well
Hsp70
CYP4Y1.
Similar
alterations
observed
gills,
reflecting
impaired
functionality
vital
organ
well.
summary,
outcomes
provide
conclusive
evidence
toxicity
quaternium-15.
This
underscores
urgent
need
investigate
toxicological
effects
contaminant
on
ecosystems
emphasises
necessity
limiting
containing
The Science of The Total Environment,
Год журнала:
2023,
Номер
881, С. 163486 - 163486
Опубликована: Апрель 15, 2023
Contaminants
of
emerging
concern
(CECs)
present
a
new
threat
to
the
marine
environment,
and
it
is
vital
understand
interactions
possible
toxicity
CEC
mixtures
once
they
reach
ocean.
CECs-such
as
metal
nanoparticles,
nanoplastics,
pharmaceuticals-are
groups
contaminants
some
which
have
been
individually
evaluated,
though
their
are
still
not
fully
understood.
To
ensure
healthy
prosperous
future
generation,
successful
reproduction
key:
however,
if
hindered,
population
dynamics
may
be
at
danger
leading
negative
impact
on
biodiversity.
This
study
aimed
effects
silver
(20
nm
nAg,
10
μg/L),
polystyrene
nanoparticles
(50
nPS,
5-fluorouracil
(5FU,
ng/L)
mixture
(10
μg/L
nPS
+
nAg
+10
ng/L
5FU)
in
gonads
Mytilus
galloprovincialis.
A
multibiomarker
approach,
namely
antioxidant
defence
system
(ADS;
superoxide
dismutase,
catalase,
glutathione
peroxidases,
-
S
transferases
activities),
oxidative
damage
(OD;
lipid
peroxidation)
were
analysed
mussels.
All
exposure
treatments
after
3
days
led
an
increase
enzymatic
activity,
followed
by
inhibition
14
21
days.
Thus,
ADS
was
overwhelmed
due
generation
ROS,
resulting
OD,
except
for
exposed
The
OD
Mix
mussels
increased
exponentially
57-fold.
When
interact,
potentially
more
hazardous
than
individual
components,
posing
major
species.
synergistic
antagonistic
interactions,
model
applied,
observed
evaluated
biomarkers
all
time-points,
apart
from
interaction
day
relative
LPO.
Results
indicate
that
Mix-exposed
mussel
mainly
5FU
but
nPS.
Environmental Research,
Год журнала:
2022,
Номер
216, С. 114560 - 114560
Опубликована: Окт. 19, 2022
The
marine
environment
has
numerous
impacts
related
to
anthropogenic
activities
including
pollution.
Abundances
of
microplastics
(MPs)
and
other
pollutants
are
continuously
increasing
in
the
environment,
resulting
a
complex
mixture
contaminants
affecting
biota.
In
order
understand
consequences,
review
studies
analyzing
combined
effects
MPs
types
bivalves
been
conducted
as
species
this
group
have
considered
sentinel
bioindicators.
Regarding
reviewed,
histological
analyses
give
evidence
that
can
be
located
haemolymph,
gills
gonads,
well
digestive
glands
intestinal
lumen,
epithelium
tubules,
demonstrating
entire
body
is
affected
by
MPs.
Moreover,
DNA
strand
breaks
represent
most
relevant
form
damage
caused
enhanced
production
reactive
oxygen
response
exposure.
role
vectors
ability
polymers
adsorb
different
compounds
also
highlighting
high
variability
results.
sense,
toxic
associated
exposure
were
found
significantly
increase
with
co-presence
antibiotics
or
petroleum
hydrocarbons
amongst
pollutants.
addition,
bioaccumulation
processes
(PAHs,
metals
others)
Histological,
genetic
physiological
alterations
reported
damages,
degree
harm
seems
correlated
concentration
size
MP
type
pollutant.
Water,
Год журнала:
2023,
Номер
15(2), С. 334 - 334
Опубликована: Янв. 13, 2023
Fipronil
is
widely
used
against
insects
in
agriculture
and
ectoparasites
domestic
areas
veterinary
medicine.
However,
fipronil
may
influence
non-target
species
as
a
result
of
the
contamination
aquatic
ecosystems.
The
present
study
aimed
to
investigate
acute
sublethal
effects
freshwater
mussels
(Unio
delicatus),
species,
with
physiological,
antioxidant
action
mechanisms
histopathological
observations.
96-h
LC50
value
was
found
be
2.64
(1.45–4.56)
mg/L.
Sublethal
concentrations
were
applied
at
1/10
1/5
0.264
mg/L
0.528
for
48-h
7-d.
Haemolymph
samples,
digestive
gland
gill
tissues
taken
after
exposure
times.
While
Total
Haemocyte
Counts
decreased
exposure,
it
only
high
fipronil-exposed
7-d
(p
<
0.05).
glutathione
values
glands
gills
higher
groups
0.05),
AOPP
Moreover,
caused
alterations
on
glands.
These
things
considered,
principal
component
analysis
revealed
that
most
pronounced
changes
by
exposure.
results
show
are
toxic
mussels.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3723 - 3723
Опубликована: Фев. 13, 2023
The
assessment
and
prediction
of
the
toxicity
engineered
nanomaterials
(NMs)
present
in
mixtures
is
a
challenging
research
issue.
Herein,
three
advanced
two-dimensional
(TDNMs),
combination
with
an
organic
chemical
(3,4-dichloroaniline,
DCA)
to
two
freshwater
microalgae
(Scenedesmus
obliquus
Chlorella
pyrenoidosa),
was
assessed
predicted
not
only
from
classical
mixture
theory
but
also
structure-activity
relationships.
TDNMs
included
layered
double
hydroxides
(Mg-Al-LDH
Zn-Al-LDH)
graphene
nanoplatelet
(GNP).
DCA
varied
type
concentration
TDNMs,
as
well
species.
exhibited
additive,
antagonistic,
synergistic
effects.
There
linear
relationship
between
different
levels
(10,
50,
90%)
effect
concentrations
Freundlich
adsorption
coefficient
(KF)
calculated
by
isotherm
models
energy
(Ea)
obtained
molecular
simulations,
respectively.
model
incorporating
both
parameters
KF
Ea
had
higher
predictive
power
for
combined
than
model.
Our
findings
provide
new
insights
development
strategies
aimed
at
evaluating
ecotoxicological
risk
NMs
towards
pollution
situations.
Frontiers in Marine Science,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 22, 2023
Introduction
Mollusks
play
a
significant
role
in
marine
ecosystems
and
have
economic
value
for
aquaculture.
Sometimes,
unexpected
unexplained
mortalities
among
mollusks
been
described.
The
of
potential
pathogens
such
as
viruses
remains
unknown
due
to
the
lack
molluscan
cell
cultures,
which
is
one
major
drawbacks
determining
viral
mortalities.
Several
oceanographic
studies
suggested
high
abundance
oceans.
Virus
identification
understanding
interaction
with
organisms
are
their
infancy.
Metatranscriptomics
could
become
useful
tool
identify
using
shotgun
approach
growing
number
genomes
sequences
deposited
public
databases.
Methods
In
this
work,
several
bioinformatics
approaches
were
set
up
screen
Mollusca
RNA
find
confirm
traces
transcriptomes.
This
meta-analysis
included
an
extensive
search
SRA
datasets
belonging
available
NCBI
database,
selecting
total
55
that
further
analyzed
searching
sequences.
Results
Twenty-two
bivalves,
19
cephalopods
16
gastropods
from
geographical
origins
17
different
tissues
considered.
domain
was
most
productive
method
virus
showed
Cephalopoda
samples
(
Idiosepius
notoides
Amphioctopus
fangsiao
)
exhibited
highest
identifications.
Some
detected
similar
or
identical
others
previously
identified.
However,
33
putative
new
identified
phylogenetically
when
RdRp
available.
Specifically,
considerable
Rhabdoviridae
family.
Environmental Toxicology and Pharmacology,
Год журнала:
2024,
Номер
106, С. 104372 - 104372
Опубликована: Янв. 18, 2024
Interaction
of
nanoplastics
(NPls)
with
other
environmental
contaminants
could
affect
their
uptake
by
the
organisms
and
toxicity.
Thus,
present
study
aims
to
investigate
polystyrene
NPls
(44
nm)
interaction
antidepressant
amitriptyline
(AMI)
its
toxicity
Danio
rerio
embryos.
A
similar
toxicological
profile
for
+
AMI
exposure
was
found
most
evaluated
endpoints,
comparing
single
exposure,
showing
that
presence
did
not
modulate
However,
behavioral
assessment
showed
a
different
pattern
hypoactivity
(NPls
–
hyperactivity;
no
effect).
effects
between
were
also
in
protein
contents
(antagonism)
total
glutathione
content
(synergism).
This
highlights
complexity
unpredictability
pharmaceuticals,
important
an
accurate
risk
developing
effective
strategies
interventions
against
plastic
pollution.
