Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 663 - 663
Опубликована: Март 7, 2023
Flavonoids
are
a
biodiverse
family
of
dietary
compounds
that
have
antioxidant,
anti-inflammatory,
antiviral,
and
antibacterial
cell
protective
profiles.
They
received
considerable
attention
as
potential
therapeutic
agents
in
biomedicine
been
widely
used
traditional
complimentary
medicine
for
generations.
Such
medical
herbal
formulations
extremely
complex
mixtures
many
pharmacologically
active
provide
outcome
through
network
pharmacological
effects
complexity.
Methods
emerging
to
determine
the
components
their
targets
decipher
complexities
how
pharmacology
provides
such
effects.
The
gut
microbiome
has
important
roles
play
generation
bioactive
flavonoid
metabolites
retaining
or
exceeding
antioxidative
anti-inflammatory
properties
intact
and,
some
cases,
new
antitumor
antineurodegenerative
bioactivities.
Certain
food
items
identified
with
high
prebiotic
profiles
suggesting
neutraceutical
supplementation
may
be
beneficially
employed
preserve
healthy
population
bacterial
symbiont
species
minimize
establishment
harmful
pathogenic
organisms.
Gut
health
is
an
consideration
effecting
overall
wellbeing
linked
organ
systems.
Bioconversion
generates
can
also
transported
by
vagus
nerve
systemic
circulation
brain
populations
exert
beneficial
effect.
This
particularly
number
neurological
disorders
(autism,
bipolar
disorder,
AD,
PD)
characterized
on
moods,
resulting
depression
anxiety,
impaired
motor
function,
long-term
cognitive
decline.
Native
flavonoids
alleviation
inflammation
tissues,
however,
concerns
raised
levels
not
achieved,
thus
allowing
them
display
optimal
Dietary
manipulation
vagal
stimulation
both
yielded
responses
treatment
autism
spectrum
disorders,
depression,
establishing
route
communication
gut-brain
axis
established
disease
intervention.
While
native
known
penetrate
blood–brain
barrier,
microbiome-generated
(e.g.,
protocatechuic
acid,
urolithins,
γ-valerolactones),
which
retain
antioxidant
potency
addition
promote
mitochondrial
cerebrovascular
microcapillary
should
considered
biotherapeutic
agents.
Studies
warranted
experimentally
examine
efficacy
directly,
they
emerge
novel
options.
Huntington's
disease
(HD)
is
a
currently
incurable
neurogenerative
disorder
and
typically
characterized
by
progressive
movement
(including
chorea),
cognitive
deficits
(culminating
in
dementia),
psychiatric
abnormalities
(the
most
common
of
which
depression),
peripheral
symptoms
gastrointestinal
dysfunction).
There
are
no
approved
disease‐modifying
therapies
available
for
HD,
with
death
usually
occurring
approximately
10–25
years
after
onset,
but
some
hold
promising
potential.
HD
subjects
often
burdened
chronic
diarrhea,
constipation,
esophageal
gastric
inflammation,
susceptibility
to
diabetes.
Our
understanding
the
microbiota–gut–brain
axis
its
infancy
growing
evidence
from
preclinical
clinical
studies
suggests
role
gut
microbial
population
imbalance
(gut
dysbiosis)
pathophysiology.
The
brain
can
communicate
through
enteric
nervous
system,
immune
vagus
nerve,
microbiota‐derived‐metabolites
including
short‐chain
fatty
acids,
bile
branched‐chain
amino
acids.
This
review
summarizes
supporting
demonstrating
alterations
bacterial
fungal
composition
that
may
be
associated
HD.
We
focus
on
mechanisms
dysbiosis
compromise
health,
thus
triggering
neuroinflammatory
responses,
further
highlight
outcomes
attempts
modulate
microbiota
as
therapeutic
strategies
Ultimately,
we
discuss
dearth
data
need
more
longitudinal
translational
this
nascent
field.
suggest
future
directions
improve
our
association
between
microbes
pathogenesis
other
‘brain
body
disorders’.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(6), С. 3535 - 3555
Опубликована: Май 20, 2024
Alzheimer's
disease
(AD)
is
a
neurological
condition
currently
with
47
million
people
suffering
from
it
globally.
AD
might
have
many
reasons
such
as
genetic
issues,
environmental
factors,
and
Aβ
accumulation,
which
the
biomarker
of
disease.
Since
primary
reason
unknown,
there
no
targeted
treatment
at
moment,
but
ongoing
research
aims
to
slow
its
progression
by
managing
amyloid-beta
peptide
production
rather
than
symptomatic
improvement.
phytochemicals
been
demonstrated
possess
antioxidant,
anti-inflammatory,
neuroprotective
properties,
they
may
target
multiple
pathological
factors
can
reduce
risk
Curcumin,
phytochemical
found
in
turmeric
known
for
free
radical
scavenging
an
antiamyloid
treating
AD,
has
come
under
investigation.
Although
low
bioavailability
limits
efficacy,
prominent
drug
delivery
system
(DDS)
desired
overcome
it.
Hence,
potency
lipid-based
nanoparticles
encapsulating
curcumin
(LNPs-CUR)
considered
this
study
promising
DDS.
In
vivo
studies
animal
models
indicate
LNPs-CUR
effectively
amyloid
plaque
formation,
leading
cognitive
enhancement
reduced
toxicity
compared
CUR.
However,
deeper
understanding
CUR's
pharmacokinetics
safety
profile
crucial
before
be
medicine.
Future
investigations
explore
combination
NPs
other
therapeutic
agents
increase
their
efficacy
cases.
This
review
provides
current
position
CUR
therapy
paradigm,
DDS
suggestions
CUR,
previous
point
analytical
view
focused
on
advantages
challenges.
