Metabolic
exchange
plays
a
crucial
role
in
shaping
microbial
community
interactions
and
functions,
including
the
of
small
molecules
such
as
cofactors.
Cofactors
are
fundamental
to
enzyme
catalytic
activities;
however,
cofactors
stress
tolerance
is
unclear.
Here,
we
constructed
synergistic
consortium
containing
two
strains
that
could
efficiently
mineralize
di-(2-ethylhexyl)
phthalate
under
hyperosmotic
stress.
Integration
transcriptomic
analysis,
metabolic
profiling,
genome-scale
model
(GEM)
facilitated
discovery
potential
mechanism
interactions.
Multi-omics
analysis
revealed
vitamin
B
Water Air & Soil Pollution,
Год журнала:
2024,
Номер
235(5)
Опубликована: Май 1, 2024
Abstract
Phthalic
acid
esters
(PAEs)
are
dialkyl
or
alkyl/aryl
ester
derivatives
of
phthalic
acid.
PAEs
colorless,
odorless,
and
flavorless
oily
liquids.
the
main
plasticizers
used
in
industry
households.
DEHP
(di-(2-ethyl
hexyl)
phthalate)
is
plasticizer
polymer
industry,
whereas
DMP
(dimethyl
DEP
(diethyl
mainly
as
solvents
fixatives
cosmetics
personal
care
products.
synthetic
organic
compounds
poorly
soluble
water
but
solvents.
Into
environment,
they
introduced
during
production,
use
degradation,
packaging,
transportation
plastic
In
degraded
three
ways:
by
hydrolysis,
photodegradation,
microbial
biodegradation
hydrolysis
environment
very
slow.
pollutants
soil,
water,
groundwater,
river
marine
air,
sediments,
vegetables,
biota.
Due
to
great
interest
subject
environmental
pollution
emergence
new
information
this
area,
it
extremely
important
systematically
review
current
knowledge.
presented
paper,
occurrence
different
matrices
was
reviewed.
The
toxicity
plants,
animals,
humans
also
described.
BMC Pregnancy and Childbirth,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 17, 2025
The
relationship
between
prenatal
phthalate
exposure
and
preterm
birth
from
previous
studies
has
been
inconsistent.
Meanwhile,
few
have
explored
the
spontaneous
(SPTB)
genetic
polymorphisms
of
metabolic
enzyme
genes
or
gene-phthalate
interactions.
aim
this
study
is
to
evaluate
association
maternal
exposure,
polymorphisms,
their
interactions
with
SPTB.
A
total
182
cases
SPTB
321
controls
full-term
delivery
were
enrolled.
Nine
metabolites
in
second
trimester
urine
samples
measured
by
ultra-high
performance
liquid
chromatography
coupled
tandem
mass
spectrometry.
Genotyping
was
performed
on
twenty-six
single
nucleotide
(SNPs)
genes,
including
CYP2C9,
CYP2C19,
UGT1A7,
UGT2B7
UGT2B15
genes.
associations
estimated
multivariable
logistic
regression
analysis.
impact
gene-gene
analyzed
via
generalized
multifactor
dimensionality
reduction.
There
no
significant
differences
concentrations
two
groups.
No
statistically
observed
rs4244285
polymorphism
CYP2C19
gene
associated
decreased
odds
under
log-additive
(aOR
=
0.73,
95%
CI:
0.55-0.98)
recessive
model
0.37,
0.18-0.74).
Two
SNP
loci
increased
3.85,
1.31-11.35
for
rs3100,
aOR
rs4148269).
However,
these
not
after
false
discovery
rate
correction.
observed.
Maternal
present
subjects
Moreover,
there
gene-phthalates
