Environmental Science & Technology,
Год журнала:
2024,
Номер
58(26), С. 11596 - 11605
Опубликована: Июнь 18, 2024
Gestational
diabetes
mellitus
(GDM)
has
been
found
to
be
a
common
complication
in
pregnant
women,
known
escalate
the
risk
of
negative
obstetric
outcomes.
In
our
study,
we
genotyped
1,566
Chinese
women
for
two
single
nucleotide
polymorphisms
(SNPs)
LINGO2
gene
and
one
SNP
GLIS3
gene,
utilizing
targeted
next-generation
sequencing.
The
impact
interacting
genes,
interaction
genes
with
environment─including
exposure
particulate
matter
(PM2.5),
ozone
(O3),
variations
prepregnancy
body
mass
index
(BMI)─on
incidence
GDM
were
analyzed
using
logistic
regression.
Our
findings
identify
variants
rs10968576
(P
=
0.022,
OR
1.224)
rs1412239
0.018,
1.231),
as
well
rs10814916
0.028,
1.172),
mutations
significantly
linked
increased
susceptibility
GDM.
Further
analysis
underscores
crucial
role
gene–gene
gene–environment
interactions
development
among
<
0.05).
Particularly,
individuals
carrying
G-rs1412239
G-rs10814916
C
haplotype
exhibit
during
period
when
PM2.5,
O3,
BMI
8.004
×
10–7,
1.206;
P
6.3264
10–11,
1.280;
9.928
1.334,
respectively).
conclusion,
research
emphasizes
importance
between
specific
variations─LINGO2
GLIS3─and
environmental
factors
influencing
risk.
Notably,
significant
associations
these
across
various
periods.
Antioxidants,
Год журнала:
2025,
Номер
14(6), С. 652 - 652
Опубликована: Май 28, 2025
As
gestational
diabetes
mellitus
(GDM)
rises
as
a
major
public
health
concern,
various
factors
have
been
identified
potential
contributors,
with
air
pollution
drawing
increasing
attention.
The
mechanisms
by
which
pollutants
lead
to
detrimental
impacts
are
largely
attributed
oxidative
stress.
However,
the
role
of
is
still
not
entirely
clarified,
suggesting
that
additional
factors,
such
genetic
variability,
particularly
genes
involved
in
redox
homeostasis,
influence
GDM
risk.
This
study
addresses
three
questions:
(1)
whether
ambient
PM2.5,
PM10,
O3,
and
NO2
exposures
associate
risk;
(2)
if
GSTM1-/GSTT1-null
genotypes
affect
risk
GDM;
(3)
these
modify
pollution–GDM
associations.
case–control
comprised
133
women
case
group
144
control
group.
Exposure
was
assessed
based
on
participants’
residential
during
different
time
windows:
pre-pregnancy
period,
first
trimester,
second
trimester.
GSTM1/GSTT1
genotyping
conducted
from
blood
samples.
Higher
O3
levels
increased
women.
While
showed
no
overall
link
GDM,
non-smokers
GSTM1-null
had
higher
when
exposed
PM2.5
further
research
gene–environment
interactions
needed,
our
findings
highlight
reducing
may
lower
Human Reproduction,
Год журнала:
2023,
Номер
39(1), С. 232 - 239
Опубликована: Ноя. 4, 2023
Do
children
born
to
mothers
with
polycystic
ovary
syndrome
(PCOS)
have
an
adverse
cardiometabolic
profile
including
arterial
stiffness
at
9
years
of
age
compared
other
children?
Abstract
Background
Gestational
diabetes
mellitus
(GDM)
is
a
complication
of
pregnancy
associated
with
numerous
adverse
outcomes.
There
may
be
potential
link
between
GDM
and
arsenic
(As)
exposure,
but
this
hypothesis
remains
controversial.
This
meta-analysis
summarizes
the
latest
studies
evaluating
association
As
GDM.
Methods
A
comprehensive
search
PubMed,
Embase,
Scopus
databases
up
to
September
2023
was
performed.
The
pooled
estimates
95%
CIs
were
presented
using
forest
plots.
Estimates
calculated
random
effects
models,
subgroup
sensitivity
analyses
conducted
address
heterogeneity.
Results
total
13
eligible
involving
2575
patients
included
in
meta-analysis.
results
showed
that
women
exposed
had
significantly
increased
risk
(OR
1.47,
CI:
1.11
1.95,
P
=
0.007).
Subgroup
suggested
heterogeneity
might
attributed
years
publication.
In
addition,
analysis
confirmed
robust
reliable
results.
Conclusions
have
greater
However,
significant
across
requires
careful
interpretation.
Registration
PROSPERO
registration
ID
CRD42023461820.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Май 28, 2024
Introduction
Gestational
diabetes
mellitus
(GDM)
is
a
form
of
gestational
characterized
by
insulin
resistance
and
abnormal
function
pancreatic
beta
cells.
In
recent
years,
genomic
association
studies
have
revealed
risk
susceptibility
genes
associated
with
genetic
to
GDM.
However,
predisposition
cannot
explain
the
rising
global
incidence
GDM,
which
may
be
related
increased
influence
environmental
factors,
especially
gut
microbiome.
Studies
shown
that
microbiota
closely
occurrence
development
This
paper
reviews
relationship
between
pathological
mechanism
in
order
better
understand
role
provide
theoretical
basis
for
clinical
application
treatment
diseases.
Methods
The
current
research
results
on
interaction
GDM
were
collected
analyzed
through
literature
review.
Keywords
such
as
"GDM",
"gut
microbiota"
"insulin
resistance"
used
search,
methodology,
findings
potential
impact
pathophysiology
systematically
evaluated.
Results
It
was
found
composition
diversity
significantly
Specifically,
abundance
certain
bacteria
an
while
other
changes
microbiome
improved
sensitivity.
addition,
alterations
affect
blood
glucose
control
variety
mechanisms,
including
production
short-chain
fatty
acids,
activation
inflammatory
pathways,
metabolism
B
vitamin
group.
Discussion
this
highlight
importance
pathogenesis
regulation
new
directions
improving
sensitivity
sugar
use
probiotics
prebiotics.
more
needed
confirm
generality
exact
mechanisms
these
explore
applications
management
diabetes.
future
should
consider
factors
how
together
they
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1461 - 1461
Опубликована: Июль 1, 2024
Introduction:
Sarcopenia
and
diabetes
mellitus
(DM)
have
been
shown
to
be
related.
It
has
demonstrated
that
pesticides/insecticides
are
linked
various
health
issues,
including
DM.
This
study
investigated
the
relationships
between
exposure
muscle
strength
among
community-dwelling
DM
patients
in
a
national
sample
of
United
States
(US).
Methods:
Data
from
2011–2012
2013–2014
U.S.
National
Health
Nutrition
Examination
Survey
(NHANES)
on
people
aged
20
years
with
were
retrieved.
A
digital
dynamometer
was
used
quantify
handgrip
strength,
urine
pesticide
concentrations
determined
through
laboratory
testing.
Regression
models
investigate
relationship
pesticide/insecticide
strength.
Results:
After
weighting,
data
412
NHANES
participants
represented
6,696,865
inhabitants.
The
mean
age
58.8
years.
High
para-nitrophenol
levels
(tertile
3
vs.
tertile
1)
associated
lower
both
males
(aBeta
=
−7.25,
95%
CI:
−11.25,
−3.25)
females
−3.73,
−6.89,
−0.56).
Further,
elevated
2-isopropyl−4-methyl-pyrimidinol
had
decreased
Desethyl
hydroxy
N,
N-diethyl-m-toluamide
(DEET)
inversely
related
men
≥60
DEET
acid
correlated
women
over
60
Conclusions:
certain
diabetes.
Para-nitrophenol,
particular,
is
negatively
muscular
females,
2-isopropyl-4-methyl-pyrimidinol
females.
