Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 4, 2024

Язык: Английский

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Associations between environmental glyphosate exposure and glucose homeostasis indices in US general adults: a national population-based cross-sectional study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 10, 2025

As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin resistance (HOMA2-IR), sensitivity (HOMA2-IS) assessed. Generalized linear models mediation analyses fitted to estimate homeostasis, ALP. demonstrated a statistically significant positive association with FPG HbA1c in dose–response manner, while showing negative HOMA2-β. Each doubling increase urinary was associated 1.13%, 1.50%, − 2.80% alteration FPG, HbA1c, HOMA2-β, respectively. Obesity modified dyshomeostasis stronger obese individuals. In addition, elevated ALP significantly mediated proportions 9.91% 20.23%, Environmental exposure dyshomeostasis, which more pronounced partly by

Язык: Английский

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Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117776 - 117776

Опубликована: Янв. 1, 2025

People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals ubiquitously distributed in the environment. Toxicological studies have indicated associations between liver fibrosis vitro vivo. However, epidemical study on deleterious effect of risk is rather limited. To examine relationship mixed exposure fibrosis, identify potential significant importance, this enrolled representative individuals from NHANES 2013-2016 survey cycles, which urinary were measured. Liver was determined based alternative noninvasive tests Fibrosis-4 index (FIB-4) Hepamet Fibrosis Score (HFS). Survey-weighted linear/logistic regression Bayesian kernel machine (BKMR) used detected independent combined respectively. In single analysis, persistent identified for 3,5,6-trichloropyridinol (TCPY), para-nitrophenol (PNP), glyphosate (GLYP) 2,4-dichlorophenoxyacetic acid (2,4-D) with both continuous dichotomous outcomes. Of them, TCPY GLYP had highest estimates, corresponding FIB-4 coefficient (β) being 0.09 (0.05-0.13, model 3) (0.06-0.12, 3), BKMR positive mixture HFS identified. The results Posterior Inclusion Probability (PIP) further showed that GLYP, TCPY, PNP main contributors overall effects mixture, PIPs 1.000 (1.000), (0.914) 0.972 (0.819) (HFS) This indicates associated increased humans, provide new insight into hepatotoxic pesticides.

Язык: Английский

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BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317908 - e0317908

Опубликована: Янв. 24, 2025

Background Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, association between and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims explore effect exposure ASCVD. Methods involved 1,602 participants employed various statistical techniques, such multivariable logistic regression, linear fitting, mediation analysis, subgroup sensitivity elucidate diseases. Results Compared with low level exposure, risk ASCVD increased significantly high (OR = 2.05, 95%CI 1.17–3.58, p<0.05, p for trend<0.05), which showed a upward trend. Further analysis found that levels angina pectoris 2.84, 1.00–8.04, coronary heart 3.76, 1.80–7.83, p<0.01, attack 2.65, 1.35–5.23, trend 0.09) were associated. Mediating BMI mediated ASCVD, an indirect 0.002405(95%CI: 0.000182–0.01, 0.02) direct 0.039336(95%CI: 0.000391–0.09), total 0.041741(95%CI: 0.002112–0.10). Conclusion Increased is associated plays mediating role in this association. In addition, higher angina, disease, attack.

Язык: Английский

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Associations between urinary glyphosate and arthritis: an US NHANES analysis

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 13, 2025

Objective As the relationship between urine glyphosate and arthritis in adults general is still unclear, study set out to investigate it. Methods A total of 1,689 people volunteered National Health Nutrition Examination Surveys (US NHANES). Utilizing a multivariate logistic regression model explore association concentrations (both continuous with categorical) risks developing arthritis, as well various types arthritis. Non-linear correlations have been investigated using restricted cubic spline smooth curve fitting. We also conducted additional subgroup analyses categorical defining features. Results Patients had levels 0.4 ng/mL, while non-arthritic individuals 0.3 ng/mL ( p &lt; 0.05). After adjusting for confounding variables, models demonstrated significant positive elevated urinary risk [1.2 (1.0, 1.4)]. This was observed osteoarthritis (OA) subgroup, an odds ratio 1.3 (95% CI: 1.1, 1.6), but not found rheumatoid (RA) or other subgroups. Smooth fitting RCS further elucidate that exhibit dose-dependent both OA, adhering linear trend (with -value nonlinearity exceeding Subsequent studies showed certain groups people, remained significant. Conclusion Increased exposure may be associated particularly osteoarthritis.

Язык: Английский

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Association of glyphosate exposure with frailty and all-cause mortality in general adults: A population-based cohort study

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 294, С. 118096 - 118096

Опубликована: Март 29, 2025

Язык: Английский

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The association of glyphosate exposure with kidney stones in American adults: A nationally representative cross-sectional study

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117189 - 117189

Опубликована: Окт. 14, 2024

Язык: Английский

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Urinary biomonitoring of exposure to glyphosate and its metabolite amino-methyl phosphonic acid among farmers and non-farmers in Morocco

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер unknown, С. 104620 - 104620

Опубликована: Дек. 1, 2024

Язык: Английский

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Antioxidant Vitamins (Vit C and E) Protect the Kidney from Glyphosate- Exposed Renal Damage in Experimental Rats - A Molecular Study

Texila international journal of public health, Год журнала: 2024, Номер 12(special issue 1)

Опубликована: Апрель 30, 2024

Glyphosate is a widely used herbicide and the active ingredient in Monsanto's Roundup, among other formulations. Vitamin C (ascorbic acid) vitamin E (tocopherol) are both antioxidants that play important roles reducing oxidative DNA damage protecting cells from harmful effects of free radicals. The study aimed to analyse effect antioxidant vitamins (vitamins E) on expression IGF-1 KIM-1 molecules kidneys glyphosate-exposed rats. Adult male Albino Wistar rats were grouped into 3. Group I: Control; II: treated (100mg); III: Glyphosate+ & treated. Serum, insulin, mRNA insulin-like growth factor (IGF-1) kidney injury (KIM-1) by RT-PCR. Serum insulin was measured ELISA method. Glyphosate-exposed developed hyperglycaemia hyper compared control but (Vitamin supplementation, reduced glyphosate mediate increased fasting blood glucose near level. Similarly, also significantly altered due induction whose found be when It concluded exposure causes renal develops diabetic nephropathy modulating kidney. potentially able reduce detrimental changes caused glyphosate. Hence, supplements could considered therapeutic drugs for nephropathy.

Язык: Английский

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Association of Urinary Glyphosate with All-Cause Mortality and Cardiovascular Mortality among Adults in NHANES 2013–2018: Role of Alkaline Phosphatase

Toxics, Год журнала: 2024, Номер 12(8), С. 559 - 559

Опубликована: Июль 31, 2024

Glyphosate is the most widely used herbicide in world. This study aimed to evaluate relationships among urinary glyphosate, all-cause mortality and cardiovascular diseases (CVD)-related general US population of adults, determine role alkaline phosphatase (ALP), an inflammation marker that associated with glyphosate exposure, these relationships. Subjects from National Health Nutrition Examination Survey (NHANES) 2013-2018 cycles were included. Survey-weighted Cox regression analysis was applied estimate relationship overall CVD mortalities. Restricted cubic spline (RCS) utilized detect linearity associations. The intermediary ALP explored by mediation analysis. Our results found consistent positive associations (HR: 1.29, 95%CI: 1.05-1.59) 1.32, 1.02-1.70). RCS curves further validated linear dose-dependent between mortality-related outcomes. Moreover, serum identified as a mediator explained 12.1% 14.0% total death risk, respectively. indicated increased humans. Increased may play essential

Язык: Английский

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