Influence and mechanism of new environmentally friendly depressant carboxymethyl-β-cyclodextrin on the flotation separation of chalcopyrite and pyrite
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Год журнала:
2024,
Номер
699, С. 134576 - 134576
Опубликована: Июнь 21, 2024
Язык: Английский
Dimethyl phthalate exposure induces cognitive impairment via COX2-mediated neuroinflammation
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
284, С. 117039 - 117039
Опубликована: Сен. 12, 2024
Язык: Английский
Dimethyl phthalate exposure induces cognitive impairment through COX2-mediated microglial activation
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 20, 2024
Abstract
AIM
We
investigated
the
mechanism
of
action
whereby
exposure
to
dimethyl
phthalate
(DMP),
an
environmental
pollutant,
causes
cognitive
impairment.
METHODS
Network
pharmacology
was
used
analyze
targets
and
regulatory
networks
associated
with
DMP-brain
injury-cognitive
The
intake
DMP
simulated
by
exposure,
Morris
water
maze
adopted
examine
tissue
levels
inflammatory
cytokines
were
detected.
Brain
damage
assayed
H&E
Nissl
staining,
protein
expression
identified
Western
blotting.
effects
observed
after
separate
application
siRNA-COX2
celecoxib-COX2
inhibitors.
In
in
vitro
experiment,
on
microglia
activation
investigated.
RESULTS
revealed
that
PTGS2
(COX2)
significantly
correlated
DMP,
which
could
act
through
COX2.
After
mice
showed
significant
brain
injury
impairment,
along
upregulation
cytokines.
inhibit
ameliorate
impairment
mice.
results
activate
cause
neuroinflammation.
CONCLUSION
can
induce
neuroinflammation
COX2-mediated
microglia,
resulting
COX2
is
important
target
for
action.
Язык: Английский
Critical role of oxygen vacancies in catalytic ozonation: Non-radical pathways and enhanced hydroxyl groups
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156952 - 156952
Опубликована: Окт. 1, 2024
Язык: Английский
Comparison of UV/PAA and VUV/PAA Processes for Eliminating Diethyl Phthalate in Water
Water,
Год журнала:
2024,
Номер
16(23), С. 3533 - 3533
Опубликована: Дек. 8, 2024
Diethyl
phthalate
(DEP)
is
a
commonly
utilized
plasticizer
that
has
gained
significant
attention
due
to
its
widespread
occurrence
in
the
environment
and
harmful
impact
on
human
health.
The
primary
objective
of
this
study
was
evaluate
compare
several
(ultraviolet)
UV-(peracetic
acid)
PAA
advanced
oxidation
processes
based
hydroxyl
radicals
degrade
DEP.
effect
UV-LEDs
incorporating
at
different
UV
ranges
(UV-A,
λ
=
365
nm;
UV-C,
254
nm
VUV,
nm)
evaluated.
results
demonstrated
DEP
successfully
degraded
both
UVC/PAA
(removal
rate
98.28%)
VUV/PAA
97.72%)
compared
UVA/PAA
process
2.71%).
competitive
method
evaluated
contribution
R-O•,
which
were
24.08%
33.92%
processes,
respectively.
We
also
effects
peroxymonosulfate
(PMS)
dosages,
irradiation,
pH
anion
coexistence
removal
In
system,
degradation
particularly
effective
about
95.52%)
over
wider
range
(3–9).
As
concentration
HCO3−
ions
increased,
there
may
have
been
some
inhibition
removal.
inhibitory
HA
Cl−
negligible.
Analysis
intermediates
revealed
primarily
occurred
via
two
pathways:
hydrolysis
hydroxylation
reactions.
This
presents
potential
mnethod
for
phthalates
offers
guidance
selection
appropriate
disinfection
technologies
drinking
water
treatment.
Язык: Английский