The adsorption behavior and mechanism of Cu(Ⅱ), Fe(Ⅱ) and Co(Ⅱ) on straw biochar and their Fenton-like performance for ciprofloxacin decontamination
Journal of Environmental Management,
Год журнала:
2025,
Номер
373, С. 123962 - 123962
Опубликована: Янв. 1, 2025
Язык: Английский
Genotoxicity Assessment of Co(II) and Ni(II) in HepG2 Cells: Insights into Combined Metal Exposure
Chemical Research in Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
The
usage
of
cobalt
(Co)
and
nickel
(Ni)
in
numerous
commercial,
industrial,
military
applications
causes
widespread
exposure
nowadays,
concerns
are
rising
about
adverse
impacts
on
human
health.
Emphasis
is
the
respiratory
system,
with
both
metals
classified
as
(possibly)
carcinogenic
upon
inhalation
by
International
Agency
for
Research
Cancer
(IARC),
but
limited
data
available
oral
exposure.
Therefore,
this
study
aims
to
evaluate
vitro
genotoxicity
Co(II)
Ni(II)
their
combination
HepG2
cells,
since
those
environmental
pollutants
occurs
realistically
concert.
Here,
led
induction
single-strand
breaks
oxidative
DNA
damage
detected
Comet
assay
FPG-sensitive
sites,
while
increased
abundance
γ-H2AX,
an
indicator
double-strand
breaks.
Notably,
combined
resulted
enhanced
damage,
especially
at
chromosomal
level,
formation
micronuclei
well
polynucleated
indicating
a
stronger
effect
compared
single
Furthermore,
induced
response
pathway
PARylation.
As
process
involves
consumption
large
amounts
cellular
NAD+
after
energy
state
was
assessed
Ni(II).
Current
indicate
that
altered
state.
This
reveals
distinct
mechanisms
exhibited
Ni(II),
which
were
treatment.
highlights
need
further
research
estimate
genotoxic
potential
targeting
cells
intake
increasing
entry.
Язык: Английский
Fractionation, spatial distribution, ecological and health risk assessment of cobalt and nickel in surface sediment of a bay along the southeast coast of China
Marine Pollution Bulletin,
Год журнала:
2024,
Номер
206, С. 116786 - 116786
Опубликована: Авг. 1, 2024
Язык: Английский
Transcriptomics pave the way into mechanisms of cobalt and nickel toxicity: Nrf2-mediated cellular responses in liver carcinoma cells
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103290 - 103290
Опубликована: Июль 27, 2024
Cobalt
(Co)
and
Nickel
(Ni)
are
used
nowadays
in
various
industrial
applications
like
lithium-ion
batteries,
raising
concerns
about
their
environmental
release
public
health
threats.
Both
metals
potentially
carcinogenic
may
cause
neurological
cardiovascular
dysfunctions,
though
underlying
toxicity
mechanisms
have
to
be
further
elucidated.
This
study
employs
untargeted
transcriptomics
analyze
downstream
cellular
effects
of
individual
combined
Co
Ni
human
liver
carcinoma
cells
(HepG2).
The
results
reveal
a
synergistic
effect
Ni,
leading
significantly
higher
number
differentially
expressed
genes
(DEGs)
compared
exposure.
There
was
clear
enrichment
Nrf2
regulated
linked
pathways
such
as
glycolysis,
iron
glutathione
metabolism,
sphingolipid
confirmed
by
targeted
analysis.
exposure
alone
caused
nuclear
translocation,
while
only
affects
evidenced
upregulation
HMOX-1
storage
protein
FTL.
impact
increasing
dihydroceramide
levels
decreasing
ceramides,
sphingosine
lactosylceramides,
along
with
diacylglycerol
accumulation.
By
combining
analytical
methods,
this
provides
valuable
insights
into
molecular
toxicity,
paving
the
way
for
understanding
metal
stress.
Язык: Английский