Chemical Reviews,
Год журнала:
2020,
Номер
120(18), С. 10516 - 10543
Опубликована: Сен. 8, 2020
The
development
of
catalytic
enantioselective
transformations,
enabling
the
construction
complex
molecular
scaffolds
from
simple
precursors,
has
been
a
long-standing
challenge
in
organic
synthesis.
Recent
achievements
transition-metal
catalyzed
functionalizations
carbon–hydrogen
(C–H)
bonds
represent
promising
pathway
toward
this
goal.
Over
last
two
decades,
iridium
catalysis
evolved
as
valuable
tool
stereocontrolled
synthesis
chiral
molecules
via
C–H
activation.
iridium-based
systems
with
various
ligand
classes,
well
studies
their
reaction
mechanisms,
resulted
dynamic
progress
area.
This
review
aims
to
present
comprehensive
picture
by
complexes
emphasis
on
mechanisms
activation
step.
Chemical Reviews,
Год журнала:
2023,
Номер
123(12), С. 7692 - 7760
Опубликована: Май 10, 2023
Site-predictable
and
chemoselective
C–H
bond
functionalization
reactions
offer
synthetically
powerful
strategies
for
the
step-economic
diversification
of
both
feedstock
fine
chemicals.
Many
transition-metal-catalyzed
methods
have
emerged
selective
activation
bonds.
However,
challenges
regio-
chemoselectivity
with
application
to
highly
complex
molecules
bearing
significant
functional
group
density
diversity.
As
molecular
complexity
increases
within
structures
risks
catalyst
intolerance
limited
applicability
grow
number
groups
potentially
Lewis
basic
heteroatoms.
Given
abundance
bonds
already
diversified
such
as
pharmaceuticals,
natural
products,
materials,
design
selection
reaction
conditions
tolerant
catalysts
has
proved
critical
successful
direct
functionalization.
such,
innovations
formation
carbon–carbon
been
discovered
developed
overcome
these
limitations.
This
review
highlights
progress
made
metal-catalyzed
C–C
forming
including
alkylation,
methylation,
arylation,
olefination
targets.
ACS Catalysis,
Год журнала:
2020,
Номер
10(23), С. 13748 - 13793
Опубликована: Ноя. 12, 2020
Direct
catalytic
transformation
of
C–H
bonds
to
new
functionalities
has
provided
a
powerful
strategy
synthesize
complex
molecular
scaffolds
in
straightforward
way.
Unstinting
efforts
the
synthetic
community
have
helped
overcome
long-standing
major
challenge
regioselectivity
by
introducing
directing
group
concept.
However,
full
potential
cannot
be
realized
unless
activated
are
stereochemically
controlled.
The
enantioselective
bond
functionalization
could
provide
an
imperative
tool
for
sustainable
way
synthesizing
chiral
scaffolds.
Despite
intrinsic
challenges
achieving
stereocontrol,
developed
different
tools
order
achieve
stereoselective
functionalization.
In
this
review,
we
discuss
remarkable
recent
advances
emerging
area
C(sp2)–H
highlight
and
opportunities,
emphasizing
techniques
so
far.
Chemistry - A European Journal,
Год журнала:
2020,
Номер
26(33), С. 7346 - 7357
Опубликована: Янв. 29, 2020
Transition-metal-catalyzed
C-H
functionalization
reactions
with
Cp*MIII
catalysts
(M=Co,
Rh,
Ir)
have
found
a
wide
variety
of
applications
in
organic
synthesis.
Albeit
the
intrinsic
difficulties
achieving
catalytic
stereocontrol
using
these
due
to
their
lack
additional
coordination
sites
for
external
chiral
ligands
and
conformational
flexibility
Cp
ligand,
enantioselective
Group
9
metal
triad
Cp-type
been
intensively
studied
since
2012.
In
this
minireview,
progress
according
type
catalyst
used
are
summarized
discussed.
The
development
Cpx
complexes
thereof,
artificial
metalloenzymes,
carboxylate-assisted
activations,
alkylations
assisted
by
carboxylic
acids
or
sulfonates,
transient
directing
groups
Chemical Reviews,
Год журнала:
2020,
Номер
120(18), С. 10516 - 10543
Опубликована: Сен. 8, 2020
The
development
of
catalytic
enantioselective
transformations,
enabling
the
construction
complex
molecular
scaffolds
from
simple
precursors,
has
been
a
long-standing
challenge
in
organic
synthesis.
Recent
achievements
transition-metal
catalyzed
functionalizations
carbon–hydrogen
(C–H)
bonds
represent
promising
pathway
toward
this
goal.
Over
last
two
decades,
iridium
catalysis
evolved
as
valuable
tool
stereocontrolled
synthesis
chiral
molecules
via
C–H
activation.
iridium-based
systems
with
various
ligand
classes,
well
studies
their
reaction
mechanisms,
resulted
dynamic
progress
area.
This
review
aims
to
present
comprehensive
picture
by
complexes
emphasis
on
mechanisms
activation
step.
