Small, Год журнала: 2024, Номер 20(47)
Опубликована: Авг. 16, 2024
Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.
Язык: Английский
Процитировано
17Guiding the rational design of biocompatible metal-organic frameworks for drug delivery
Matter, Год журнала: 2025, Номер 8(3), С. 101958 - 101958
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
3Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics
Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100406 - 100406
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2Advancing Cancer Therapy with Quantum Dots and Other Nanostructures: A Review of Drug Delivery Innovations, Applications, and Challenges
Cancers, Год журнала: 2025, Номер 17(5), С. 878 - 878
Опубликована: Март 4, 2025
Nanotechnology, particularly quantum dots (QDs), has ushered in a transformative era the pharmaceutical and medical industries, offering notable opportunities for nanoscale advancements. These particles, known their exceptional optical properties confinement, have emerged as indispensable tools cancer drug delivery bioimaging. This review delves into various conjugation techniques with QDs, including covalent linking, non-covalent conjugation, click chemistry, disulfide linkage, pH-sensitive linkage. Each method provides distinct advantages, such enhanced stability, reversibility, specificity, controlled release. Moreover, QDs demonstrated significant promise oncology by efficiently delivering drugs to cancerous tissues while minimising systemic toxicity. Investigations applications different cancers, blood, brain, cervical, breast etc., reveal efficacy targeted delivery, real-time imaging, improved therapeutic outcomes. However, challenges potential toxicity, pharmacokinetics, targeting specificity must be addressed fully harness benefits of therapy. Future research should focus on developing biocompatible optimising techniques, elucidating safety profiles long-term effects biological systems. Overall, represent promising frontier treatment, multifaceted capabilities that hold outcomes reduced side across cancers.
Язык: Английский
Процитировано
2Bioremediation of organic pollutants by laccase-metal–organic framework composites: A review of current knowledge and future perspective
Bioresource Technology, Год журнала: 2024, Номер 406, С. 131072 - 131072
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
15Enhancing Drug Delivery Efficacy Through Bilayer Coating of Zirconium-Based Metal–Organic Frameworks: Sustained Release and Improved Chemical Stability and Cellular Uptake for Cancer Therapy
Chemistry of Materials, Год журнала: 2024, Номер 36(8), С. 3588 - 3603
Опубликована: Апрель 11, 2024
The development of nanoparticle (NP)-based drug carriers has presented an exciting opportunity to address challenges in oncology. Among the 100,000 available possibilities, zirconium-based metal–organic frameworks (MOFs) have emerged as promising candidates biomedical applications. Zr-MOFs can be easily synthesized small-size NPs compatible with intravenous injection, whereas ease decorating their external surfaces functional groups allows for targeted treatment. Despite these benefits, suffer degradation and aggregation real, vivo conditions, loaded drugs will burst effect─i.e., fast release less than 48 h. To tackle issues, we developed a simple but effective bilayer coating strategy generic, two-step process. In this work, bilayer-coated MOF NU-901 remained well dispersed biologically relevant fluids such buffers cell growth media. Additionally, enhances long-term stability drug-loaded MOFs water by simultaneously preventing sustained leakage particles. We evaluated our materials encapsulation transport pemetrexed, standard-of-care chemotherapy mesothelioma. allowed slowed pemetrexed over 7 days, superior typical h found bare MOFs. This slow related performance were studied vitro using both A549 lung cancer 3T mesothelioma cells. Using high-resolution microscopy, successful uptake cells accumulation lysosomes. pemetrex-loaded was indeed cytotoxic Finally, demonstrated general approach extending two additional lipids four surfactants. research highlights how yet provides new insights into design MOF-based delivery systems.
Язык: Английский
Процитировано
14Hyaluronic acid functionalized citric acid dendrimer/UiO-66-COOH as a stable and biocompatible platform for daunorubicin delivery
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131590 - 131590
Опубликована: Апрель 14, 2024
Язык: Английский
Процитировано
10Recent Advances in Metal–Organic Frameworks as Oxidase Mimics: A Comprehensive Review on Rational Design and Modification for Enhanced Sensing Applications
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based systems. This review explores various advantages that MOFs offer terms catalytic activity, low-cost, stability, structural versatility. With a primary focus on their application biochemical sensing, oxidases demonstrated remarkable utility, prompting thorough exploration design modification strategies. Moreover, aims to provide comprehensive analysis strategies employed rational MOF structures optimize key parameters such sensitivity, selectivity, stability context sensors. Through an exhaustive examination recent research developments, this article seeks insights into nuanced interplay between performance, shedding light mechanisms underpin effectiveness mimics. Finally, addresses challenges opportunities associated with aiming drive further advancements structure development highly effective sensors for diverse applications.
Язык: Английский
Процитировано
10Nanoscale Metal–Organic Frameworks as a Photoluminescent Platform for Bioimaging and Biosensing Applications
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 16, 2024
The tracking of nanomedicines in their concentration and location inside living systems has a pivotal effect on the understanding biological processes, early-stage diagnosis, therapeutic monitoring diseases. Nanoscale metal-organic frameworks (nano MOFs) possess high surface areas, definite structure, regulated optical properties, rich functionalized sites, good biocompatibility that allow them to excel wide range biomedical applications. Controllable syntheses functionalization endow nano MOFs with better properties as imaging agents sensing units for diagnosis treatment This minireview summarizes tunable synthesis strategies controllable size, shape, luminescent performance, pinpoints recent advanced applications elements bioimaging biosensing. current limitations future development directions MOF-contained materials biosensing are also discussed, aiming expand MOF-based nanomedicine facilitate production or clinical translation.
Язык: Английский
Процитировано
9Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
Abstract Despite improvements in cancer survival rates, metastatic and surgery‐resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses limited treatment options. Enhancing drug bioavailability tumors, while minimizing off‐target effects, is crucial. Metal–organic frameworks (MOFs) have emerged promising delivery vehicles owing to their high loading capacity, biocompatibility, functional tunability. However, the vast chemical diversity of MOFs complicates rational design biocompatible materials. This study employed machine learning molecular simulations identify suitable for encapsulating gemcitabine, paclitaxel, SN‐38, identified PCN‐222 an optimal candidate. Following loading, MOF formulations are improved colloidal stability biocompatibility. In vitro studies on cell lines shown cellular internalization, delayed release. Long‐term tests demonstrated a consistent performance over 12 months. vivo tumor‐bearing mice revealed that paclitaxel‐loaded PCN‐222, particularly hydrogel local administration, significantly reduced spread tumor growth compared free drug. These findings underscore potential effective system hard‐to‐treat cancers.
Язык: Английский
Процитировано
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