Psychology Research and Behavior Management, Год журнала: 2024, Номер Volume 17, С. 2161 - 2178
Опубликована: Май 1, 2024
There is evidence that adverse childhood experiences (ACEs) and negative life events (NLEs) are associated with major depression (MDD).
Язык: Английский
Journal of Affective Disorders, Год журнала: 2022, Номер 323, С. 884 - 892
Опубликована: Дек. 22, 2022
Язык: Английский
Процитировано
45
Translational Neurodegeneration, Год журнала: 2023, Номер 12(1)
Опубликована: Май 12, 2023
Abstract Neurological conditions, including cognitive impairment and Alzheimer’s disease (AD), impose a huge burden on society, affecting millions of people globally. In addition to genetic factors, recent studies indicate that environmental experiential factors may contribute the pathogenesis these diseases. Early life adversity (ELA) has profound impact brain function health later in life. rodent models, exposure ELA results specific deficits aggravated AD pathology. Extensive concerns have been raised regarding higher risk developing impairments with history ELA. this review, we scrutinize findings from human animal focusing connection AD. These discoveries suggest ELA, especially at early postnatal stages, increases susceptibility terms mechanisms, could lead dysregulation hypothalamus-pituitary-adrenal axis, altered gut microbiome, persistent inflammation, oligodendrocyte dysfunction, hypomyelination, aberrant adult hippocampal neurogenesis. Crosstalks among events synergistically Additionally, discuss several interventions alleviate adverse consequences Further investigation into crucial area will help improve management reduce related neurological conditions.
Язык: Английский
Процитировано
39
Journal of Child Psychology and Psychiatry, Год журнала: 2023, Номер 64(6), С. 952 - 965
Опубликована: Фев. 8, 2023
Background Early‐life adversity is associated with adverse mental health outcomes and poorer cognitive functioning in later development. However, little known about how early‐life adversity, health, cognition affect one another or the effects unfold over time. Here, we test hypothesis that may lead to challenges which turn have consequences for development of abilities. Methods In a large ( N = 13,287) longitudinal (5 wave) sample assessed at ages 3, 5, 7, 11 14, use both path analysis approach latent growth curve mediation model study whether childhood mediate on working memory vocabulary outcomes. Results We found significant total association between performance (β .123, p < .001, [95% CI 0.106, 0.141]) scores −.111, −0.129, −0.093]). Notably, current previous mediated substantial proportion (working memory: 59%; vocabulary: 70%) these effects. Further modeling showed has an enduring effect complementary using model, indirect associations through baseline age 3 (intercept: β .083, 0.072, 0.094]) change across 3–11 (slope: −.012, −0.019, −0.005]). Likewise, −.095, −0.107, −0.083]) 3–14 .007, 0.003, 0.011]) significantly completely relation outcome. Conclusions These findings important potential clinical educational implications, because they suggest academic resilience be supported early interventions vulnerable children.
Язык: Английский
Процитировано
14
Journal of Affective Disorders, Год журнала: 2024, Номер 351, С. 331 - 340
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
5
International Journal of Translational Medicine, Год журнала: 2021, Номер 1(3), С. 205 - 222
Опубликована: Ноя. 9, 2021
Food insecurity (FI) has negative implications across the life course that include poor health outcomes among both children and adults. However, behavioral mechanisms by which FI impacts behaviors are not clear. By understanding how is related to cognitive function/brain structure course, we can design more targeted interventions. A systematic literature review was performed conducting comprehensive database searches in Google Scholar PubMed. Inclusion criteria required studies measures of humans. Study sample, design, outcomes, biases were extracted. In total, 17 met inclusion criteria. Cognitive domains included general cognition (n = 13), executive function 10), visuospatial abilities 4), verbal memory 8). No examined brain structure. Most (88%) indicated significant inverse associations between all stages particularly for function. Significant observed either or 3) adults 12). All considered confounding variables; however, given observational, no causality be inferred from findings. These findings indicate lower course. Research should explore changes food security status develop optimal interventions improve health.
Язык: Английский
Процитировано
27
Biomolecules, Год журнала: 2025, Номер 15(2), С. 161 - 161
Опубликована: Янв. 22, 2025
Early life adversity (ELA) has long been recognized to negatively impact a variety of health outcomes, with increasingly long-term implications for neurocognitive function. ELA may affect the brain through multiple mechanisms, including chronic inflammation. One potential moderator pathway from neuroinflammation cognitive dysfunction is sex. leave females potentially even more vulnerable impairment in later life. This review discusses influence on function across much lifespan, how inflammation implicated this process, and current state knowledge regarding sex differences these relationships. We conclude discussion unanswered questions suggestions future research, incorporation genetic data.
Язык: Английский
Процитировано
0
Journal of Traumatic Stress, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Abstract Childhood maltreatment is recognized as a risk factor for cognitive decline in adulthood. However, the mechanisms underlying this association, particularly role of systemic inflammation, remain understudied. To address gap, study investigated indirect effects inflammation on associations between childhood and both episodic memory (EM) executive functioning (EF) performance 10 years after inflammatory measurement older adults. We selected 590 participants ( M age = 65.5 years) from Midlife United States Study based available maltreatment, composite data. Spearman's rank correlations were calculated to test among cognition, inflammation. The results informed follow‐up analyses testing cognition. Correlations demonstrated that was associated with overall well specific domains (i.e., physical abuse, sexual emotional neglect), p s .002–.010. Inflammation negatively EF, .001, EM, .028. Follow‐up revealed significant pathways linking β −.0088, SE 0.0058, 95% CI [−0.0223, −0.00000], EM through but no domain drove association. suggest may help explain links exposure deficits These elucidate importance evaluating later‐life decline, within context heightened biomarkers.
Язык: Английский
Процитировано
0
The Journal of Prevention of Alzheimer s Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
3
The Journals of Gerontology Series B, Год журнала: 2022, Номер 77(7), С. 1361 - 1371
Опубликована: Янв. 26, 2022
Abstract Objectives The rising prevalence of cognitive impairment, Alzheimer’s disease, and related disorders signals the need for a better understanding how social factors may affect health millions Americans. Drawing from cumulative inequality theory, we aim to understand implications stressful childhood on relationships in later life. Methods This study utilizes longitudinal data (2006–2016) Health Retirement Study examine pathways, both direct indirect through adulthood, stressors trajectories over time. Results Respondents reporting greater number had worse time, but those negative effects were not as steep time progressed. Early-life are also associated with less support more strain adulthood which, turn, initial health. Finally, pathway analyses confirm that indirectly support. Discussion Findings reveal creates chains risks have lifelong health, directly by creating obstacles developing healthy supportive relationships.
Язык: Английский
Процитировано
14
Preventive Medicine, Год журнала: 2022, Номер 162, С. 107124 - 107124
Опубликована: Июль 3, 2022
Язык: Английский
Процитировано
14