Ginseng-Based Nanotherapeutics in Cancer Treatment: State-of-the-Art Progress, Tackling Gaps, and Translational Achievements
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 250 - 250
Опубликована: Апрель 3, 2025
Among
medicinal
plants,
the
Panax
genus
(family:
Araliaceae)
includes
plant
species
widely
recognized
for
their
multi-faceted
pharmacological
attributes.
The
triterpenoids,
designated
as
ginsenosides,
are
increasingly
drug-like
molecules
in
cancer
therapies
due
to
therapeutic
role
restricting
tumor
invasion,
proliferation,
metastasis,
apoptosis,
and
drug
resistance
reversal
cells.
In
nanobiotechnological
era,
nano-delivery
systems
provide
feasible
solutions
address
bottlenecks
associated
with
traditional
delivery
methods
(low
bioavailability,
instability
gastrointestinal
tract,
high
dosage
requirements,
side
effects,
poor
absorption,
incomplete
utilization
body).
dedicated
efforts
precise
effective
treatment
have
directed
development
of
ginsenoside-based
achieve
potent
anticancer
efficacies
limitations
ginseng
pharmacokinetics,
facilitating
trials.
Studies
into
pharmacokinetics
showed
a
remarkable
prolonged
clearance
free
levels
~15%
(ginsenoside
RB1
nanoparticles)
mice
(compared
only
~5%
ginsenosides)
better
antitumor
efficacies,
demonstrating
key
success
biotechnology
development.
Delving
interventions
ginseng-derived
therapeutics,
this
study
summarizes
current
advances
achievements,
particularly
treatment,
tackles
existing
gaps,
focuses
on
solutions,
examines
prospects
translational
success.
Язык: Английский
Application of the Ginsenoside Multidimensional Information Library (GinMIL) Enables Accurate Characterization of Ginsenosides from Diverse Ginseng Products and Accelerates the Discovery of New Saponin Compounds
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Accurate
characterization
of
ginsenosides
from
ginseng
relying
on
liquid
chromatography-mass
spectrometry
(LC-MS)
is
challenging
due
to
the
lack
sufficient
structural
information.
By
machine
learning
techniques,
we
have
established
a
ginsenoside
multidimensional
information
library,
namely,
GinMIL,
covering
four
dimensions
579
ginsenosides.
This
work
was
designed
accurately
characterize
Panax
notoginseng
products
and
rapidly
discover
novel
quinquefolius
flowers
by
ion-mobility
LC/MS
profiling
efficient
GinMIL
matching
UNIFI.
Consequently,
characterized
334/356/738/545
three
parts/two
extracts/four
single
preparations/seven
compound
preparations
notoginseng,
respectively.
45/99/59/116
masses
were
discovered
in
types
products,
Four
ginsenosides,
including
rare
dimalonyl
one
methylated
malonyl
ginsenoside,
isolated
feat
analysis.
can
verify
superiority
thus
greatly
enhancing
multicomponent
discovery
new
compounds
functional
herbs.
Язык: Английский