It
has
previously
been
shown
that
the
consumption
of
probiotics
may
have
beneficial
effects
not
only
on
peripheral
tissues
but
also
central
nervous
system
and
behavior
via
microbiota-gut-brain
axis,
raising
possibility
treatment
with
could
be
an
effective
therapeutic
strategy
for
managing
neurodegenerative
disorders.
In
this
study,
we
investigated
oral
administration
Bifidobacterium
breve
strain
A1
(B.
A1)
physiological
processes
in
Alzheimer's
disease
(AD)
model
mice.
We
found
B.
to
AD
mice
reversed
impairment
alternation
a
Y
maze
test
reduced
latency
time
passive
avoidance
test,
indicating
it
prevented
cognitive
dysfunction.
demonstrated
non-viable
components
bacterium
or
its
metabolite
acetate
partially
ameliorated
decline
observed
Gene
profiling
analysis
revealed
suppressed
hippocampal
expressions
inflammation
immune-reactive
genes
are
induced
by
amyloid-β.
Together,
these
findings
suggest
potential
preventing
AD.
European Journal of Nutrition,
Год журнала:
2018,
Номер
57(S1), С. 1 - 14
Опубликована: Май 1, 2018
The
2017
annual
symposium
organized
by
the
University
Medical
Center
Groningen
in
Netherlands
focused
on
role
of
gut
microbiome
human
health
and
disease.
Experts
from
academia
industry
examined
interactions
prebiotics,
probiotics,
or
vitamins
with
disease,
development
early-life
gut-brain
axis.
microbiota
changes
dramatically
during
pregnancy
intrinsic
factors
(such
as
stress),
addition
to
extrinsic
diet,
drugs)
influence
composition
activity
throughout
life.
Microbial
metabolites,
e.g.
short-chain
fatty
acids
affect
signaling
immune
response.
has
a
regulatory
anxiety,
mood,
cognition
pain
which
is
exerted
via
Ingestion
prebiotics
probiotics
been
used
treat
range
conditions
including
constipation,
allergic
reactions
infections
infancy,
IBS.
Fecal
transplantation
(FMT)
highly
effective
for
treating
recurrent
Clostridium
difficile
infections.
affects
virtually
all
aspects
health,
but
degree
scientific
evidence,
models
technologies
understanding
mechanisms
action
vary
considerably
one
benefit
area
other.
For
clinical
practice
be
broadly
accepted,
mode
action,
therapeutic
window,
potential
side
effects
need
thoroughly
investigated.
This
calls
further
coordinated
state-of-the
art
research
better
understand
document
microbiome's
health.
Molecular Neurobiology,
Год журнала:
2020,
Номер
57(12), С. 5026 - 5043
Опубликована: Авг. 22, 2020
Understanding
how
gut
flora
influences
gut-brain
communications
has
been
the
subject
of
significant
research
over
past
decade.
The
broadening
term
"microbiota-gut-brain
axis"
from
"gut-brain
underscores
a
bidirectional
communication
system
between
and
brain.
microbiota-gut-brain
axis
involves
metabolic,
endocrine,
neural,
immune
pathways
which
are
crucial
for
maintenance
brain
homeostasis.
Alterations
in
composition
microbiota
associated
with
multiple
neuropsychiatric
disorders.
Although
causal
relationship
dysbiosis
neural
dysfunction
remains
elusive,
emerging
evidence
indicates
that
may
promote
amyloid-beta
aggregation,
neuroinflammation,
oxidative
stress,
insulin
resistance
pathogenesis
Alzheimer's
disease
(AD).
Illustration
mechanisms
underlying
regulation
by
pave
way
developing
novel
therapeutic
strategies
AD.
In
this
narrative
review,
we
provide
an
overview
their
dysregulation
Novel
insights
into
modification
as
preventive
or
approach
AD
highlighted.
It
has
previously
been
shown
that
the
consumption
of
probiotics
may
have
beneficial
effects
not
only
on
peripheral
tissues
but
also
central
nervous
system
and
behavior
via
microbiota-gut-brain
axis,
raising
possibility
treatment
with
could
be
an
effective
therapeutic
strategy
for
managing
neurodegenerative
disorders.
In
this
study,
we
investigated
oral
administration
Bifidobacterium
breve
strain
A1
(B.
A1)
physiological
processes
in
Alzheimer's
disease
(AD)
model
mice.
We
found
B.
to
AD
mice
reversed
impairment
alternation
a
Y
maze
test
reduced
latency
time
passive
avoidance
test,
indicating
it
prevented
cognitive
dysfunction.
demonstrated
non-viable
components
bacterium
or
its
metabolite
acetate
partially
ameliorated
decline
observed
Gene
profiling
analysis
revealed
suppressed
hippocampal
expressions
inflammation
immune-reactive
genes
are
induced
by
amyloid-β.
Together,
these
findings
suggest
potential
preventing
AD.
