Fermented foods and gastrointestinal health: underlying mechanisms

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 21(4), С. 248 - 266

Опубликована: Дек. 11, 2023

Язык: Английский

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Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

Life, Год журнала: 2024, Номер 14(5), С. 559 - 559

Опубликована: Апрель 26, 2024

The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such dietary fibers. Through fermentation these food components, short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced, offering numerous health benefits host. production absorption SCFAs occur through various mechanisms within human intestine, contingent upon types fibers reaching specific engaged fermentation. Medical literature extensively documents supplementation SCFAs, particularly butyrate, treatment gastrointestinal, metabolic, cardiovascular, gut-brain-related disorders. This review seeks provide an overview dynamics involved gut. Additionally, it will focus on roles promoting metabolic health, well their current therapeutic implications.

Язык: Английский

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Short-chain Fatty Acids and Human Health: from Metabolic Pathways to Current Therapeutic Implication

Опубликована: Март 27, 2024

The gastrointestinal tract is colonized by trillions of different microorganisms, named the gut microbiota, which key to degrade undigested food such as dietary fibers. fermentation these components leads production short-chain fatty acids (SCFA) acetate, propionate, and butyrate, exploit several beneficial roles for host’s health. Their absorption happen in ways human intestine depend on type fiber reaching microorganisms involved fermentation. supplementation SCFAs, mostly treating gastrointestinal, metabolic, cardiovascular, gut-brain-related diseases has been reported medical literature. This review aims give an overview dynamics butyrate gut, with a final focus role played SCFAs metabolic health present therapeutic implications.

Язык: Английский

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The influence of Akkermansia muciniphila on intestinal barrier function

Gut Pathogens, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 3, 2024

Intestinal barriers play a crucial role in human physiology, both homeostatic and pathological conditions. Disruption of the intestinal barrier is significant factor pathogenesis gastrointestinal inflammatory diseases, such as bowel disease. The profound influence gut microbiota on diseases has sparked considerable interest manipulating it through dietary interventions, probiotics, fecal transplantation potential approaches to enhance integrity barrier. Numerous studies have underscored protective effects specific their associated metabolites. In recent years, an increasing body research demonstrated that Akkermansia muciniphila (A. muciniphila, Am) plays beneficial various including diabetes, obesity, aging, cancer, metabolic syndrome. It gaining popularity regulator influences flora recognized 'new generation probiotics'. Consequently, may represent target promising therapy option for diseases. This article systematically summarizes Am gut. Specifically, we carefully discuss key scientific issues need resolution future regarding bacteria represented by Am, which provide insights application drugs targeting clinical treatment.

Язык: Английский

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Superiority of native soil core microbiomes in supporting plant growth

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 4, 2024

Native core microbiomes represent a unique opportunity to support food provision and plant-based industries. Yet, these are often neglected when developing synthetic communities (SynComs) plant health growth. Here, we study the contribution of native core, non-core non-native microorganisms production. We construct four alternative SynComs based on excellent growth promoting ability individual stain paired non-antagonistic action. One microbiome SynCom (SC2) shows high niche breadth low average variation degree in-vitro interaction. The promoting-growth effect SC2 can be transferred non-sterile environment, attributing colonization improvement rhizosphere function including nitrogen fixation, IAA production, dissolved phosphorus. Further, microbial fertilizer composite carrier (rapeseed cake + rice husk carbon) increase net biomass by 129%. Our results highlight fundamental importance boost authors show that have greater potential than both microorganisms.

Язык: Английский

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

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Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study

iMeta, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research primarily focused on differential abundances, our study highlights the role of non-differential microbes in We propose that contribute hypertension through their ecological interactions, as defined co-abundances (pairs exhibiting correlated abundance patterns). Using gut microbiome data from Guangdong Gut Microbiome Project, which includes 2355 hypertensive 4644 non-hypertensive participants across 14 regions, we identified replicable hypertension-related interactions. Notably, most involved microbes, were found correlate with both severity metabolic pathways. These findings emphasize importance interactions pathogenesis a novel perspective for microbiome-based therapeutic strategies.

Язык: Английский

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Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration

Cell Reports Medicine, Год журнала: 2023, Номер 4(9), С. 101190 - 101190

Опубликована: Сен. 1, 2023

Research on gut microbiota has generally focused fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to small Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly allow for more efficient fluid absorption) also results in intimate host-microbe interactions despite rapid transit. It thus crucial dissect key differences both ecology physiology between intestine better leverage immense potential human imprinting, including probiotic engraftment biological sensible niches. Here, we provide a detailed review unfolding how physiological affect composition, function, plasticity. This information understanding manipulation, administration, may strain-dependently transform defined locations.

Язык: Английский

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Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Апрель 17, 2024

With an increasing interest in dietary fibers (DFs) to promote intestinal health and the growth of beneficial gut bacteria, there is a continued rise incorporation refined DFs processed foods. It still unclear how fibers, such as guar gum, affect microbiota activity pathogenesis inflammatory bowel disease (IBD). Our study elucidated effect underlying mechanisms fermentable DF (FDF) commonly present wide range foods, on colitis development. We report that gum containing diet (GuD) increased susceptibility colonic inflammation. Specifically, GuD-fed group exhibited severe upon dextran sulfate sodium (DSS) administration, evidenced by reduced body weight, diarrhea, rectal bleeding, shortening colon length compared cellulose-fed control mice. Elevated levels pro-inflammatory markers both serum [serum amyloid A (SAA), lipocalin 2 (Lcn2)] (Lcn2) extensive disruption architecture further affirmed more than DSS intervention. Amelioration pre-treated with antibiotics suggest vital role GuD-mediated exacerbation Gut composition metabolite analysis fecal cecal contents, respectively, revealed primarily enriches Actinobacteriota, specifically Bifidobacterium. Guar also altered multiple genera belonging phyla Bacteroidota Firmicutes. Such shift favored luminal accumulation intermediary metabolites succinate lactate Colonic IL-18 tight junction were decreased group. Importantly, mice recombinant displayed attenuated colitis. Collectively, unfavorable changes leading succinate, IL-18, compromised barrier function following feeding contributed susceptibility.

Язык: Английский

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Modulation of gut microbiota and metabolites by Flammulina velutipes polysaccharides during in vitro human fecal fermentation: Unveiling Bacteroides as a potential primary degrader

Food Chemistry, Год журнала: 2024, Номер 450, С. 139309 - 139309

Опубликована: Апрель 10, 2024

Язык: Английский

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