COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions DOI Open Access
Amália Cínthia Meneses do Rêgo, Irami Araújo-Filho

Archives of Cancer Science and Therapy, Год журнала: 2024, Номер 8(1), С. 054 - 062

Опубликована: Сен. 4, 2024

Background: The impact of COVID-19 and long-term on gastrointestinal neoplasms remains underexplored. current review investigates the potential link between these conditions role gut microbiota in mediating oncogenic processes. Dysbiosis, characterized by alterations microbial composition, may exacerbate inflammation immune dysregulation, contributing to cancer development. Methods: A comprehensive literature was conducted using databases including PubMed, Scopus, Embase, SciELO, Web Science. Inclusion criteria encompassed studies published 2020 2024 that explored intersection COVID-19, cancers. articles were critically appraised for quality relevance, data synthesized elucidate common mechanisms outcomes. Results: identifies several which influence risk patients. Persistent inflammation, oxidative stress, dysfunction observed Long COVID associated with dysbiosis. Specific metabolites, such as secondary bile short-chain fatty acids, implicated promoting tumorigenesis. Comparative analysis suggests SARS-CoV-2-induced dysbiosis heighten susceptibility cancers, particularly patients prolonged post-infection symptoms. Conclusion: findings underscore need further research clarify development among These could inform preventative strategies therapeutic interventions, those experiencing COVID. highlights gaps knowledge advocates longitudinal assess effects health.

Язык: Английский

The trio of circadian clock, intestinal flora, and cancer DOI
Weici Liu, Zheshun Pi, Wenjun Mao

и другие.

Trends in Molecular Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1
Enhanced CRC Growth in Iron-Rich Environment, Facts and Speculations DOI Open Access
Marcello Chieppa, Marianna Kashyrina, Alessandro Miraglia

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12389 - 12389

Опубликована: Ноя. 19, 2024

The contribution of nutritional factors to disease development has been demonstrated for several chronic conditions including obesity, type 2 diabetes, metabolic syndrome, and about 30 percent cancers. Nutrients include macronutrients micronutrients, which are required in large trace quantities, respectively. Macronutrients, protein, carbohydrates, lipids, mainly involved energy production biomolecule synthesis; micronutrients vitamins minerals, immune functions, enzymatic reactions, blood clotting, gene transcription. Among the numerous potentially development, present review will focus on iron its relation tumor development. Recent advances understanding iron-related proteins accumulating microenvironment shed light pivotal role availability sustaining pathological hallmarks, cell cycle regulation, angiogenesis, metastasis.

Язык: Английский

Процитировано

1
COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions DOI Open Access
Amália Cínthia Meneses do Rêgo, Irami Araújo-Filho

Archives of Cancer Science and Therapy, Год журнала: 2024, Номер 8(1), С. 054 - 062

Опубликована: Сен. 4, 2024

Background: The impact of COVID-19 and long-term on gastrointestinal neoplasms remains underexplored. current review investigates the potential link between these conditions role gut microbiota in mediating oncogenic processes. Dysbiosis, characterized by alterations microbial composition, may exacerbate inflammation immune dysregulation, contributing to cancer development. Methods: A comprehensive literature was conducted using databases including PubMed, Scopus, Embase, SciELO, Web Science. Inclusion criteria encompassed studies published 2020 2024 that explored intersection COVID-19, cancers. articles were critically appraised for quality relevance, data synthesized elucidate common mechanisms outcomes. Results: identifies several which influence risk patients. Persistent inflammation, oxidative stress, dysfunction observed Long COVID associated with dysbiosis. Specific metabolites, such as secondary bile short-chain fatty acids, implicated promoting tumorigenesis. Comparative analysis suggests SARS-CoV-2-induced dysbiosis heighten susceptibility cancers, particularly patients prolonged post-infection symptoms. Conclusion: findings underscore need further research clarify development among These could inform preventative strategies therapeutic interventions, those experiencing COVID. highlights gaps knowledge advocates longitudinal assess effects health.

Язык: Английский

Процитировано

0