Exploration of Medicine, Год журнала: 2025, Номер 6
Опубликована: Май 7, 2025
Vaccines are typically designed either for human or veterinary use. Using One Health principles it would be more efficient to develop a single vaccine cover all animal and species at threat from specific pathogen. A major issue designing vaccines is that some commonly used adjuvants such as aluminium salts not suitable species, felines, where they can cause injection site sarcomas. Conversely, mineral oil emulsions too reactogenic in humans. In addition, species-specific differences innate immune receptors Toll-like (TLR) may mean an adjuvant works one does work another. This review presents overview of use this list identifies those might most strategy. Two notable candidates already supported by both data squalene delta inulin-CpG combination known Advax-CpG55.2. These two have been shown safe effective across multiple including when formulated influenza vaccines. could highly relevant selection development against the current North American bovine H5N1 avian outbreak with potential need susceptible birds, cattle cats addition Additional considerations administration routes dosing widely varying size, physiology genetics. The availability Advax-CpG55.2 broad activity safety, humans, should make approaches common future.
Язык: Английский