Enrichment of the flavonoid fraction fromEucommia ulmoidesleaves by a liquid antisolvent precipitation method and evaluation of antioxidant activitiesin vitroandin vivo

RSC Advances, Год журнала: 2023, Номер 13(25), С. 17406 - 17419

Опубликована: Янв. 1, 2023

Eucommia ulmoides leaves originate from the dry of plant. Flavonoids are main functional components leaves. Some flavonoids such as rutin, kaempferol and quercetin rich in ulmoides, they have outstanding antioxidant efficacy. However, poor water solubility significantly affects bioavailability flavonoids. In this study, we used a liquid antisolvent precipitation (LAP) method to enrich flavonoid fractions leaves, prepared nanoparticles by LAP increase flavonoids' properties. The technological parameters were optimized Box-Behnken Design (BBD) software displayed follows: (1) total (TFs) concentration: 83 mg mL-1; (2) antisolvent-solvent ratio: 11; (3) deposition temperature: 27 °C. Under optimal processing conditions, purity recovery rate TFs 88.32% ± 2.54% 88.08% 2.13%, respectively. vitro experiments showed that radical scavenging IC50 values for DPPH, ABTS, hydroxyl radicals superoxide anions 16.72 1.07, 10.76 0.13, 227.68 18.23 335.86 15.98 μg mL-1, vivo studies obtained purified (PF) (100, 200, 400 kg-1) treatment is able improve CCl4-induced liver kidney damage through adjusting, dismutase (SOD), catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) malondialdehyde (MDA) levels. These results demonstrated capable extracting with high bioaccessibility.

Язык: Английский

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A molecularly imprinted polymer for the efficient adsorption of morphine

Journal of Applied Polymer Science, Год журнала: 2023, Номер 141(5)

Опубликована: Ноя. 9, 2023

Abstract Molecularly imprinted polymers (MIPs) were synthesized via the precipitation polymerization technology for specific adsorption of morphine. A number (methacrylic acid, trifluoromethyl acrylic and acrylamide) studied, respectively, as precursor monomers under various synthetic conditions (the imprinting (IP) ratio, cross‐linking (CL) solvent reaction temperature, etc.). The MIP with optimal performance was derived using methacrylic acid (MAA) functional monomer, ethylene glycol dimethacrylate (EGDMA) crosslinker, azobisisobutyronitrile (AIBN) initiator, an IP ratio 1:3 a CL 5:1. This presented maximum morphine capacity 38.24 mg/g (one highest capacities ever reported in literature) at bulk concentration ~230 ppm acetonitrile solution. capacity, selectivity, reusability, well chemical mechanical stabilities confirmed by experiments, instrumental characterization, thermodynamic analysis, proposed mechanisms.

Язык: Английский

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Enantioselective recognition, synthesis, and separation of pharmaceutical compounds at chiral metallic surfaces

ChemMedChem, Год журнала: 2024, Номер 19(7)

Опубликована: Янв. 18, 2024

Abstract The development of new pharmaceutical compounds is challenging because most them are based on enantiopure chiral molecules, which exhibit unique properties for therapy. However, the synthesis in absence a environment naturally leads to racemic mixture. Thus, control their synthesis, an asymmetric required, and homogeneous catalysts typically used synthesize (EPC). Nevertheless, difficult recover after reaction, generating additional problems costs practical processes. heterogeneous timely topic. In more general context, such materials cannot only be but also recognize separate enantiomers. frame these different challenges, we give this review short introduction strategies extrinsically intrinsically modify metal matrixes enantioselective recognition, separation compounds.

Язык: Английский

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Recent progress in fabrication and application of chiral interfaces

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Год журнала: 2024, Номер 52(4), С. 100391 - 100391

Опубликована: Апрель 1, 2024

Chirality, also known as handedness, is one of the most widespread and intriguing properties in nature, touching upon various fields including physics, chemistry, biology, medicine beyond. Chiral interface place where chirality related process occurs. The development synthetic chiral not only deepens understanding mechanism, but provides basis for application phenomenon. In this review, we provide a summary types interfaces, their construction methods, recent recognition, separation, catalysis, well prospect further direction.

Язык: Английский

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Synthesis of furan-modified cationic cellulose for stereo-specific imprinting and separation of S-indacrinone via Diels-Alder reaction

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133384 - 133384

Опубликована: Июнь 24, 2024

Язык: Английский

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