ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
The
increasing
interest
in
protein
and
peptide
coacervates
is
accompanied
by
the
development
of
various
applications,
from
drug
delivery
to
biosensor
preparation.
However,
impact
end
groups
charges
on
coacervation
remains
unclear.
For
this
purpose,
we
designed
four
derivatives
with
varying
net
charges.
These
inherently
fluorescent
peptides
readily
formed
solution
or
during
evaporation.
ability
control
process,
coacervate's
appearance,
encapsulation
capabilities
were
thoroughly
investigated.
displayed
significant
antioxidant
properties,
protecting
encapsulated
material.
Additionally,
deposition
surfaces
was
achieved.
abilities
highlight
potential
these
biotechnological
including
compounds
such
as
drugs
dietary
supplements.
Exploiting
dynamic
characteristics
unique
properties
underscores
their
practical
advantages.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 11, 2023
Abstract
Synthetic
biology
aims
to
design
or
assemble
existing
bioparts
bio-components
for
useful
bioproperties.
During
the
past
decades,
progresses
have
been
made
build
delicate
biocircuits,
standardized
biological
building
blocks
and
develop
various
genomic/metabolic
engineering
tools
approaches.
Medical
pharmaceutical
demands
also
pushed
development
of
synthetic
biology,
including
integration
heterologous
pathways
into
designer
cells
efficiently
produce
medical
agents,
enhanced
yields
natural
products
in
cell
growth
media
equal
higher
than
that
extracts
from
plants
fungi,
constructions
novel
genetic
circuits
tumor
targeting,
controllable
releases
therapeutic
agents
response
specific
biomarkers
fight
diseases
such
as
diabetes
cancers.
Besides,
new
strategies
are
developed
treat
complex
immune
diseases,
infectious
metabolic
disorders
hard
cure
via
traditional
In
general,
brings
capabilities
researches.
This
review
summarizes
timeline
developments,
present
microbial
productions
pharmaceutics,
engineered
equipped
with
DNA
diagnosis
therapies,
live
auto-assemblied
biomaterials
treatments,
cell-free
fields,
approaches
potentials
biomedical
applications.
Chemical Science,
Год журнала:
2023,
Номер
14(27), С. 7411 - 7437
Опубликована: Янв. 1, 2023
This
work
reviewed
recent
advances
in
the
design,
fabrication,
and
responsiveness
of
permeable
polymersomes,
their
diverse
applications
fields
biomimetic
nanoreactors,
artificial
cells
organelles,
as
well
nanomedicine
were
highlighted.
The
exponential
growth
of
research
on
artificial
cells
and
organelles
underscores
their
potential
as
tools
to
advance
the
understanding
fundamental
biological
processes.
bottom-up
construction
from
a
variety
building
blocks
at
micro-
nanoscale,
in
combination
with
biomolecules
is
key
developing
cells.
In
this
review,
are
focused
upon
based
compartments
where
polymers
main
constituent
assembly.
Polymers
particular
interest
due
incredible
chemical
advantage
tuning
properties
functionality
assemblies.
First,
architectures
nanoscale
polymer
assemblies
introduced
then
usage
elaborated
upon.
Different
membrane-bound
membrane-less
supramolecular
structures
how
they
combine
into
advanced
synthetic
presented.
Then,
functional
aspects
explored,
addressing
giant
mimic
cellular
Finally,
communicate
surrounding
each
other
such
adapt
an
ever-changing
environment
achieve
collective
behavior
steppingstone
toward
tissues,
taken
look
at.
Engineering
highly
controllable
programmable
features
open
new
avenues
for
development
sophisticated
multifunctional
systems.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 18, 2024
Multiple
enzyme-induced
cascade
catalysis
has
an
indispensable
role
in
the
process
of
complex
life
activities,
and
is
widely
used
to
construct
robust
biosensors
for
analyzing
various
targets.
The
immobilized
multi-enzyme
system
a
novel
biomimetic
strategy
that
immobilizes
enzymes
with
different
functions
stable
carriers
simulate
synergistic
multiple
biological
systems,
which
enables
high
stability
efficiency
enzymatic
catalysis.
Nanozymes,
type
nanomaterial
intrinsic
enzyme-like
characteristics
excellent
stabilities,
are
also
applied
instead
achieving
better
catalytic
performance
reaction
stability.
Due
good
stability,
reusability,
remarkably
efficiency,
multi-enzyme/nanozyme
systems
show
distinct
advantages
promoting
signal
transduction
amplification,
thereby
attracting
vast
research
interest
biosensing
applications.
This
review
focuses
on
progress
recent
years.
construction
approaches,
factors
affecting
applications
sensitive
discussed
detail.
Further,
their
challenges
outlooks
future
study
provided.
Abstract
In
the
extant
lifeforms,
self‐sustaining
behaviors
refer
to
various
well‐organized
biochemical
reactions
in
spatial
confinement,
which
rely
on
compartmentalization
integrate
and
coordinate
molecularly
crowded
intracellular
environment
complicated
reaction
networks
living/synthetic
cells.
Therefore,
biological
phenomenon
of
has
become
an
essential
theme
field
synthetic
cell
engineering.
Recent
progress
state‐of‐the‐art
cells
indicated
that
multi‐compartmentalized
should
be
developed
obtain
more
advanced
structures
functions.
Herein,
two
ways
developing
hierarchical
systems,
namely
interior
(organelles)
integration
communities
(synthetic
tissues),
are
summarized.
Examples
provided
for
different
construction
strategies
employed
above‐mentioned
engineering
ways,
including
spontaneous
vesicles,
host–guest
nesting,
phase
separation
mediated
multiphase,
adhesion‐mediated
assembly,
programmed
arrays,
3D
printing.
Apart
from
exhibiting
functions,
also
applied
as
biomimetic
materials.
Finally,
key
challenges
future
directions
regarding
development
systems
summarized;
these
expected
lay
foundation
creation
a
“living”
well
provide
larger
platform
new
materials
future.
Journal of Colloid and Interface Science,
Год журнала:
2023,
Номер
637, С. 408 - 420
Опубликована: Янв. 21, 2023
Herein,
we
report
a
straightforward,
scalable
synthetic
route
towards
poly(ionic
liquid)
(PIL)
homopolymer
nanovesicles
(NVs)
with
tunable
particle
size
of
50
to
120
nm
and
shell
thickness
15
60
via
one-step
free
radical
polymerization
induced
self-assembly.
By
increasing
monomer
concentration
for
polymerization,
their
nanoscopic
morphology
can
evolve
from
hollow
NVs
dense
spheres,
finally
directional
worms,
in
which
multilamellar
packing
PIL
chains
occurred
all
samples.
The
transformation
mechanism
NVs'
internal
is
studied
detail
by
coarse-grained
simulations,
revealing
correlation
between
the
chain
length
NVs.
To
explore
potential
applications,
varied
are
situ
functionalized
ultra-small
(1
∼
3
size)
copper
nanoparticles
(CuNPs)
employed
as
electrocatalysts
CO2
electroreduction.
composite
exhibit
2.5-fold
enhancement
selectivity
C1
products
(e.g.,
CH4),
compared
pristine
CuNPs.
This
attributed
strong
electronic
interactions
CuNPs
surface
functionalities
study
casts
new
aspects
on
using
nanostructured
PILs
electrocatalyst
supports
conversion
products.
Abstract
The
fast‐growing
pace
of
regenerative
medicine
research
has
allowed
the
development
a
range
novel
approaches
to
tissue
engineering
applications.
Until
recently,
main
points
interest
in
majority
studies
have
been
combine
different
materials
control
cellular
behavior
and
use
techniques
optimize
formation,
from
3‐D
bioprinting
situ
regeneration.
However,
with
increase
understanding
fundamentals
organization,
development,
regeneration,
also
come
realization
that
for
next
step
engineering,
higher
level
spatiotemporal
on
cell‐matrix
interactions
is
required.
It
proposed
combination
artificial
cell
could
provide
route
toward
over
complex
development.
By
equipping
cells
underlying
mechanisms
functions,
such
as
communication
mechanisms,
migration
behavior,
or
coherent
depending
surrounding
matrix
properties,
they
can
be
applied
instructing
native
into
desired
differentiation
at
resolution
not
attained
traditional
materials.
Biomacromolecules,
Год журнала:
2024,
Номер
25(9), С. 5468 - 5488
Опубликована: Авг. 23, 2024
Biomolecular
condensates
are
dynamic
liquid
droplets
through
intracellular
liquid-liquid
phase
separation
that
function
as
membraneless
organelles,
which
highly
involved
in
various
complex
cellular
processes
and
functions.
Artificial
analogs
formed
via
similar
pathways
can
be
integrated
with
biological
complexity
advanced
functions
have
received
tremendous
research
interest
the
field
of
synthetic
biology.
The
coacervate
droplet-based
compartments
partition
concentrate
a
wide
range
solutes,
regarded
attractive
candidates
for
mimicking
phase-separation
behaviors
biophysical
features
biomolecular
condensates.
use
peptide-based
materials
phase-separating
components
has
advantages
such
diversity
amino
acid
residues
customized
sequence
design,
allows
programming
their
physicochemical
properties
resulting
compartments.
In
this
Perspective,
we
highlight
recent
advancements
design
construction
biomimicry
from
peptides
relevant
to
protein,
specific
reference
molecular
self-assembly
separation,
biorelated
applications,
envisage
emerging
biomedical
delivery
vehicles.
Chemical Communications,
Год журнала:
2022,
Номер
59(7), С. 807 - 835
Опубликована: Ноя. 11, 2022
Transferring
the
layer-by-layer
(LbL)
coating
approach
from
planar
surfaces
to
spherical
templates
and
subsequently
dissolving
these
leads
fabrication
of
polyelectrolyte
multilayer
capsules.
The
versatility
coatings
capsules
their
flexibility
upon
bringing
in
virtually
any
material
into
has
quickly
drawn
substantial
attention.
Here,
we
provide
an
overview
main
developments
this
field,
highlighting
trends
last
decade.
In
beginning,
various
methods
encapsulation
release
are
discussed
followed
by
a
broad
range
applications,
which
were
developed
explored.
We
also
outline
current
trends,
where
applications
is
continuing
grow,
including
addition
whole
new
different
application
areas.
