Bacterial
resistance
to
antibiotics
has
rendered
bacterial
infections
an
escalating
threat
public
health,
prompting
numerous
researchers
strive
towards
the
development
of
novel
antimicrobial
agents.
Designable
ionic
liquids
(ILs)
have
gained
increasing
prominence
in
field
antibacterials.
However,
certain
ILs
exhibit
suboptimal
activity
and
limited
biocompatibility.
In
this
study,
we
synthesized
liquid-derived
carbon
dots
(IL-CDs)
through
vinyl
epoxy
group
reactions,
resulting
enhanced
efficacy
favorable
The
IL-CDs
retain
antibacterial
structure
characteristic
ILs,
including
a
positively
charged
imidazole
long
alkyl
chain.
Moreover,
demonstrate
selective
action
against
Staphylococcus
aureus
(S.
aureus)
while
effectively
inhibiting
S.
biofilm
growth.
Notably,
superior
potency
compared
commercially
available
quaternary
ammonium
salt-based
We
conducted
comprehensive
investigations
into
mechanism
which
primarily
involves
electrostatic
interactions,
hydrophobic
as
well
generation
reactive
oxygen
species
(ROS)
within
bacteria
cells.
vivo
experiments
demonstrated
that
significantly
alleviate
inflammation
expedite
wound
healing
aureus-infected
mice
models;
thus
highlighting
their
potential
therapeutic
candidates
for
diseases
resembling
infection-like
conditions.
Importantly,
our
work
presents
approach
utilizing
IL-based
materials
developing
effective
antibacterials
thereby
offering
new
insights
application
prospects
IL-derived
materials.
Bioengineering,
Год журнала:
2025,
Номер
12(2), С. 137 - 137
Опубликована: Янв. 31, 2025
Surgical
wound
infections
are
a
major
cause
of
postoperative
complications,
contributing
to
surgical
morbidity
and
mortality.
With
the
rise
antibiotic-resistant
pathogens,
it
is
crucial
develop
new
innovative
materials
manage
using
methods
that
facilitate
drug
delivery
agents
rely
on
other
than
antimicrobials.
Nanoparticles,
in
particular,
have
captured
researchers'
interest
recent
years
due
their
effectiveness
care.
They
can
be
classified
into
three
main
types:
inorganic
nanoparticles,
lipid-based
polymeric
nanoparticles.
Several
studies
demonstrated
these
technologies
enhancing
wound-healing
times
reducing
bacterial
burden.
However,
further
research
essential
thoroughly
evaluate
safety
toxicity
before
they
integrated
routine
practice.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
663, С. 124562 - 124562
Опубликована: Авг. 5, 2024
The
aim
of
this
study
was
the
evaluation
suitability
novel
mucoadhesive
hydrogel
platforms
for
delivery
therapeutics
useful
management
disorders
related
to
gastrointestinal
tract
(GI).
At
purpose,
here
we
describe
preparation,
physicochemical
characterization
and
drug
behaviour
hydrogels,
based
on
self-assembling
lipopeptides
(MPD02-09),
obtained
by
covalently
conjugating
lauric
acid
(LA)
SNA's
peptide
derivatives
gotten
variously
combining
D-
L-
amino
residues.
LA
conjugation
aimed
at
improving
stability
precursor
peptides,
obtaining
amphiphilic
structures,
triggering
hydrogels
formation
through
self-assembling.
Budesonide
(BUD),
an
anti-inflammatory
drug,
selected
as
model
because
its
use
in
treatment
GI
disorders.
Preliminary
studies
were
performed
correlate
chemical
structure
conjugates
with
key
properties
materials
delivery.
Two
lipopeptides,
MPD03
MPD08,
found
form
(MPD03h
MPD08h,
respectively)
characteristics
suitable
These
showed
mucoadhesiveness
about
60
%.
In
vitro
carried
out
BUD
loaded
70
%
release
within
6
h.
Wound
healing
assessed
Caco-2
HaCaT
cells,
reduction
cell-free
area
values
lower
than
10
Taking
together
these
results
MPD03h
MPD08h
have
been
shown
be
excellent
candidates
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(6), С. 745 - 755
Опубликована: Апрель 21, 2024
Nanoliposomes
loaded
with
ivermectin
possess
the
ability
to
deliver
drug
an
intended
area,
ensuring
optimal
stability
and
eventual
release
at
that
precise
location.
The
nanoliposome's
size
range
results
in
expanded
surface
which
enables
delivery
of
maximum
amount
medication
designed
This
investigation
shows
thin
film
lipid
hydration
technique
can
be
employed
formulate
nanoliposomes.
For
formulation,
cholesterol
phosphatidylcholine
was
chosen
applying
response
methodology
(RSM).
With
a
zeta
potentials
from
-13.4
±0.14
mV
-34.5
±0.11
mV,
average
dimension
particles
different
formulation
tested
this
study
is
between
93.2
nm
156.4
nm.
factorial
design
optimization
demonstrates
entrapment
efficiency
(Y3)
has
p-value
0.0160,
percentage
medicament
rate
8
hours
(Y1)
0.0414,
12
hour
(Y2)
0.0119.
Therefore,
all
models
responses
were
significant.
After
thorough
assessment
present
investigation,
it
found
F7
batch
highest
R2
value
n
exponent,
kinetics
ivermectin-loaded
nanoliposome
accompanied
zero-order
model
as
well
korsmeyer–peppas
model.
Additionally,
current
demonstrated
histopathological
assessments
course
wound
healing
animal
Investigated
showcased
nanoliposomes
substantial
possibility
nano
conveyor
for
targeted
system.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(7), С. 1115 - 1141
Опубликована: Июль 2, 2024
Introduction
Wound
healing
is
an
intricate
and
continual
process
influenced
by
numerous
factors
that
necessitate
suitable
environments
to
attain
healing.
The
natural
ability
of
wound
often
gets
altered
several
external
intrinsic
factors,
leading
chronic
occurrence.
Numerous
dressings
have
been
developed,
however,
the
currently
available
alternatives
fail
coalesce
all
conditions
obligatory
for
rapid
skin
regeneration.
