Nanotechnology in the life sciences, Год журнала: 2024, Номер unknown, С. 293 - 317
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140787 - 140787
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
3
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(8), С. 1973 - 1990
Опубликована: Янв. 1, 2024
The treatment of chronic refractory wounds poses significant challenges and threats to both human society the economy. Existing research studies demonstrate that electrical stimulation fosters cell proliferation migration promotes production cytokines expedites wound healing process. Presently, clinical settings utilize devices for treatment, but these often present issues such as limited portability necessity frequent recharging. A cutting-edge dressing employing piezoelectric effect could transform mechanical energy into energy, thereby providing continuous accelerating healing, effectively addressing concerns. This review primarily reviews selection materials their application in design, offering a succinct overview underlying mechanisms. study also provides perspective on current limitations dressings future development multifunctional harnessing effect.
Язык: Английский
Процитировано
17
Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6445 - 6510
Опубликована: Янв. 1, 2024
Overview of natural and engineered material-binding peptides the molecular forces crucial for their (material-specific) binding to material surfaces.
Язык: Английский
Процитировано
11
Biomimetics, Год журнала: 2024, Номер 9(6), С. 373 - 373
Опубликована: Июнь 20, 2024
The sophisticated, elegant protein-polymers designed by nature can serve as inspiration to redesign and biomanufacture protein-based materials using synthetic biology. Historically, petro-based polymeric have dominated industrial activities, consequently transforming our way of living. While this benefits humans, the fabrication disposal these causes environmental sustainability challenges. Fortunately, biopolymers compete with potentially surpass performance polymers because they be biologically produced degraded in an environmentally friendly fashion. This paper reviews four groups polymers, including fibrous proteins (collagen, silk fibroin, fibrillin, keratin), elastomeric (elastin, resilin, wheat glutenin), adhesive/matrix (spongin conchiolin), cyanophycin. We discuss connection between protein sequence, structure, function, biomimetic applications. Protein engineering techniques, such directed evolution rational design, used improve functionality natural materials. For example, inclusion specific domains, particularly those observed structural proteins, collagen, enables creation novel exceptional mechanical properties adaptability. review also discusses recent advancements production application new through approach biology combined biomimetics, providing insight for future research development cutting-edge bio-inspired products. Protein-based that utilize nature's designs a base, then modified at intersection engineering, may provide mankind more sustainable
Язык: Английский
Процитировано
10
Composites Part A Applied Science and Manufacturing, Год журнала: 2025, Номер 192, С. 108767 - 108767
Опубликована: Фев. 2, 2025
Язык: Английский
Процитировано
1
Foods, Год журнала: 2024, Номер 13(19), С. 3027 - 3027
Опубликована: Сен. 24, 2024
Conventional passive packaging plays a crucial role in food manufacturing by protecting foods from various external influences. Most materials are polymer-based plastics derived fossil carbon sources, which favored for their versatility, aesthetic appeal, and cost-effectiveness. However, the extensive use of these poses significant environmental challenges due to fossil-based origins persistence environment. Global plastic consumption is expected nearly triple 2060, exacerbating ecological crisis. Moreover, globalization has increased access diverse range around world, heightening importance providing healthier safer with extended shelf life. In response challenges, there growing shift eco-friendly active that not only protects but also preserves authentic qualities food, surpassing roles conventional packaging. This article provides comprehensive review on viability, benefits, implementing bio-based biodegradable polymers packaging, dual goals sustainability extending
Язык: Английский
Процитировано
6
Biomimetics, Год журнала: 2024, Номер 9(7), С. 428 - 428
Опубликована: Июль 15, 2024
This study follows the process for development of an innovative biomimetic composite derived from bovine collagen with keratin, hydroxyapatite being hybridized into its architecture, and it builds a comprehensive evaluation composite's characteristics. The novel materials are tailored special traits to be achieved repair osteochondral defects (OCDs). purpose present research is create reliable effective alternative existing bone graft while leveraging intrinsic properties components enhanced osteoinduction integration. composites were characterized based on their morphological properties, including water absorption, through scanning electron microscopy (SEM), structural by Fourier-Transform Infrared Spectroscopy (FTIR). Biological performance was assessed in vitro using human marrow mesenchymal stem cells (BMSCs), focusing cytotoxicity, cell viability, ability support colonization forthcoming results. vivo illustrates real potential that this class exhibits regard cartilage tissue engineering encourages further exploration future clinical applications.
Язык: Английский
Процитировано
5
Deleted Journal, Год журнала: 2024, Номер 1(1)
Опубликована: Дек. 9, 2024
Tissue engineering and regenerative medicine are multidisciplinary disciplines that use technical biological principles to create workable replacements for human tissues organ function. Keratin, a protein found in materials like wool, feathers, hooves, holds great promise biomedical applications due its unique properties. It is biocompatible, providing suitable matrix cell growth tissue repair. Keratin's cysteine-rich composition facilitates attachment growth, supporting the regeneration of damaged tissue. The method electrospinning flexible effective way producing nanofibers. To generate fibers with high surface area volume ratio, this technique applies an electric field draw charged threads polymer melts or solutions. Further, extraction, purification, characterization keratin proteins from hair wool have yielded significant advances over past century, resulting development keratin-based biomaterials platforms. Researchers successfully fabricated nanofiber scaffolds using techniques, mimicking natural extracellular (ECM) promoting infiltration adhesion. These been investigated different engineering, vitro studies showing successful skin cells on them, making them promising wound healing Keratin biomaterial utilized because biocompatibility, biodegradability, latent activity, cellular binding designs. Understanding scaffolds' biodegradation, stability vivo, mechanism action essential more sophisticated applications, including clinical research. Additional research development, addition advancements related technologies, ought even prospects versatile fascinating biomaterial.
Язык: Английский
Процитировано
3
Journal of Separation Science, Год журнала: 2025, Номер 48(1)
Опубликована: Янв. 1, 2025
ABSTRACT A comprehensive strategy, including spectroscopic, molecular simulation, proteomics, and bioinformatics techniques, was employed to investigate a novel triazole, 5‐(4‐methoxyphenyl)‐1‐phenyl‐1H‐1,2,3‐triazole, its interactions with high‐abundance blood proteins, identification of low‐abundance proteins. The binding constants thermodynamic parameters the triazole two globular human serum albumin, immunoglobulin G (HIgG), were obtained by spectroscopic techniques computational chemistry. two‐dimensional gel electrophoresis in combination matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry isolate identify differentially expressed proteins samples following exposure triazole. results indicated that there is strong albumin/HIgG hydrophobic interaction plays main role system. There 21 highly identified from intervened By analysis, one differential kininogen‐1 protein, explore mechanism action 5‐(4‐methoxyphenyl)‐1‐phenyl‐1H‐1,2,3‐triazole intervention on kallikrein–kinin signaling pathways related HeLa cervical cancer cells. displayed antiproliferative activity significantly altered kallikrein‐10 expression, suggesting possible antitumor involving These research findings provide scientific insights for further development application 1,2,3‐triazole compound. study highlights potential compound as multifunctional pharmaceutical agent, particularly therapies, lays foundation future clinical applications targeting drug–protein interactions.
Язык: Английский
Процитировано
0
Systems Microbiology and Biomanufacturing, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0