Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140674 - 140674
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
4
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 20, 2025
Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims develop novel composite material combining enzymatic nanoparticles nerve growth factor (NGF) modulate immune microenvironment enhance SCI repair. CeMn (NP) NP-polyethylene glycol (PEG) nanozymes were synthesized via sol–gel reaction DSPE-mPEG modification. Transmission Electron Microscopy, Selected-Area Diffraction, X-ray Diffraction Photoelectron Spectroscopy confirmed their crystalline structure, mixed-valence states, redox properties. Size uniformity, biocompatibility, catalytic activity assessed hydrodynamic diameter, zeta potential, elemental analysis. The Lightgel/NGF/CeMn NP-PEG was characterized electron microscopy, compression testing, rheological analysis, NGF release kinetics, 30-day degradation studies. Both in vitro vivo experiments conducted evaluate effects of on SCI. successfully synthesized, exhibiting favorable physical At concentration 4 µg/mL, maintained cell viability demonstrated enhanced biological activity. It also showed superior mechanical properties an effective profile. Notably, significantly upregulated expression growth-associated proteins, reduced inflammatory cytokines, scavenged reactive oxygen species (ROS), promoted M2 macrophage polarization by inhibiting cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway. In rat model, it facilitated functional recovery attenuated inflammation. shows significant promise for SCI, effectively eliminating ROS, promoting polarization, reducing pro-inflammatory supporting neuronal regeneration. These substantially motor function rats, positioning promising candidate future clinical applications.
Язык: Английский
Процитировано
2
Plasma Processes and Polymers, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
ABSTRACT Cold Atmospheric Plasma (CAP) is a novel method for biomaterial fabrication, inducing physicochemical changes in biomolecules. Keratin, an industrial waste product valued its biocompatibility and biodegradability, formed self‐assembled structures under CAP treatment, as revealed by SEM. Zeta analysis showed increased surface charge, while TGA XRD confirmed enhanced crystallinity with sharp‐edged nanocrystalline structures. Unique self‐assembly behaviors were observed un‐dialyzed dialyzed keratin. modified keratin's through reactive oxygen nitrogen species (RONS), physical without altering chemical structure or native conformation. This highlights CAP's potential to tailor keratin properties specific applications.
Язык: Английский
Процитировано
1
Polymer, Год журнала: 2024, Номер 307, С. 127304 - 127304
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133218 - 133218
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139737 - 139737
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Silk fibroin (SF) hydrogel has been proven to have excellent applications in the field of pressure sensors, but its sensing performance still needs improvement. A flexible prepared from natural macromolecular materials was developed, and lignin nanoparticles (LNPs) were introduced during preparation SF hydrogel. When LNPs account for 3% SF, unit SF-LNPs3% exhibits high stress sensitivity (1.32 kPa–1), fast response speed (<0.1 s), superior cycle stability (≥8000 cycles). The sensor can detect human motion information, such as finger bending, elbow pulse signals. worn at vocal cord position, it peak value characteristic signal wearer speaks. This work demonstrates that shows great potential sensors.
Язык: Английский
Процитировано
0
Journal of Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
ABSTRACT Burn wounds care and healing are very difficult in clinic. Herein, a multifunctional waterproof hydrogel was fabricated with photothermal antimicrobial NO anti‐inflammatory properties. In the as‐prepared hydrogel, polyethyleneimine (PEI) thioctic acid (TA) were cross‐linked by electrostatic interactions hydrogen bonding while aggregation of TA could be favor to formation hydrophobic caves. Benefit from caves, CuS BNN6 (N, N′‐dibutyl‐N, N′‐dinitroso‐1,4‐phenylenediamine) incorporated PEI/TA‐based air permeability also increased. Interestingly, mild increased temperature conversion not only endowed ability but promoted release BNN6. The PEI/TA/CuS/BNN6 good biocompatibility, self‐healing water resistance suitable for promoting burn healing. It provides new platform designing novel wound dressing wounds.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140613 - 140613
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161021 - 161021
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0