Progress in Medical Devices,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
In
the
field
of
bioanalysis,
integration
magnetic
beads
and
biosensors
provides
a
protein
detection
platform
with
high
separation
efficiency
sensitivity.
The
superparamagnetism
beads,
combined
surface
functional
modifications,
forms
basis
for
selectively
capturing
effectively
separating
target
proteins.
Additionally,
sensitivity
specificity
ensure
precise
quantitative
analysis
captured
This
article
systematically
reviews
synthesis
strategies
functionalized
methods
proteins
nucleic
acids,
as
well
current
technical
challenges
future
development
directions.
ACS Omega,
Год журнала:
2025,
Номер
10(1), С. 1207 - 1225
Опубликована: Янв. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
This
study
provides
a
bibliometric
and
bibliographic
review
of
emerging
applications
micro-
nanotechnology
in
treating
ocular
diseases,
with
primary
focus
on
glaucoma.
We
aim
to
identify
key
research
trends
analyze
advancements
devices
drug
delivery
systems
for
treatments.
The
methodology
involved
analyzing
385
documents
indexed
the
Web
Science
using
tools
such
as
VOSviewer
Bibliometrix.
results
show
marked
increase
scientific
output,
highlighting
prominent
authors
institutions,
England
leading
field.
Key
findings
suggest
that
holds
potential
address
limitations
conventional
treatments,
including
low
bioavailability
adverse
side
effects.
Nanoparticles,
nanovesicles,
polymer-based
appear
promising
prolonged
controlled
release,
potentially
offering
enhanced
therapeutic
efficacy.
In
conclusion,
could
transform
disease
treatment,
although
challenges
remain
concerning
biocompatibility
scalability
these
devices.
Further
clinical
studies
are
necessary
establish
innovations
within
context
ophthalmology.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(8), С. 227 - 227
Опубликована: Авг. 14, 2024
A
wide
range
of
applications
using
functionalized
magnetic
nanoparticles
(MNPs)
in
biomedical
applications,
such
as
biomedicine
well
biotechnology,
have
been
extensively
expanding
over
the
last
years.
Their
potential
is
tremendous
delivery
and
targeting
systems
due
to
their
advantages
biosubstance
binding.
By
applying
materials-based
biomaterials
different
organic
polymers,
highly
advanced
multifunctional
bio-composites
with
high
specificity,
efficiency,
optimal
bioavailability
are
designed
implemented
various
bio-applications.
In
modern
drug
delivery,
importance
a
successful
therapy
depends
on
proper
loaded
bioactive
components
specific
sites
body.
MNPs
nanocarrier-based
that
magnetically
guided
regions
an
external
field.
Therefore,
excellent
tool
for
form
imaging
agents,
sensors,
targets/vehicles,
diagnostic
tools
managing
disease
therapy.
great
contribution
was
made
improve
engineering
skills
surgical
diagnosis,
therapy,
treatment,
while
applicability
opened
up
large
scope
studies.
This
review
highlights
synthesis
strategies,
followed
by
surface
functionalization
techniques,
which
makes
them
promising
biomedicine,
special
emphasis
delivery.
Mechanism
system
key
factors
affecting
efficiency
discussed,
considering
toxicity
limitations
well.
Microchimica Acta,
Год журнала:
2025,
Номер
192(4)
Опубликована: Март 5, 2025
The
review
article
provides
a
short
introduction
to
exosomes
with
the
focus
use
as
disease
markers
itself
(i.e.
their
concentration
or
presence
of
some
specific
receptors)
source
biomarkers
such
proteins
and
metabolites.
In
detail,
we
are
discussing
various
methods
exosome
isolation
main
paper
is
on
affinity
capture
exosomes,
since
them
can
be
applied
sub-populations
produced
by
organs.
comprehensive
overview
magnetic
(bio)affinity
detection
exosomal
cargo
using
different
ligands
antibodies,
DNA
aptamers,
peptides,
glycan-based
recognition,
transferrin-based
approaches,
based
recognition
phospholipids
other
approaches
including
electrostatic
interactions.
in
detail
key
analytical
clinical
parameters
form
an
extensive
table
summarising
outcomes
published
last
two
years
(2023-2024).
Finally,
also
conclusions
sections
pros
cons
for
and/or
determination
content.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7691 - 7708
Опубликована: Июль 1, 2024
Abstract:
Gene
therapy
aims
to
add,
replace
or
turn
off
genes
help
treat
disease.
To
date,
the
US
Food
and
Drug
Administration
(FDA)
has
approved
14
gene
products.
With
increasing
interest
in
therapy,
feasible
delivery
vectors
are
necessary
for
inserting
new
into
cells.
There
different
kinds
of
including
viral
like
lentivirus,
adenovirus,
retrovirus,
adeno-associated
virus
et
al,
non-viral
naked
DNA,
lipid
vectors,
polymer
nanoparticles,
exosomes
with
viruses
being
most
commonly
used.
Among
them,
concerned
vector
is
(AAV)
because
its
safety,
natural
ability
efficiently
deliver
cells
sustained
transgene
expression
multiple
tissues.
In
addition,
AAV
genome
can
be
engineered
generate
recombinant
(rAAV)
containing
sequences
been
proven
a
safe
vector.
Recently,
rAAV
have
treatment
various
rare
diseases.
Despite
these
approvals,
some
major
limitations
remain,
namely
nonspecific
tissue
targeting
host
immune
response.
Additional
problems
include
neutralizing
antibodies
that
block
delivery,
finite
packaging
capacity,
high
titer
used
per
dose
cost.
deal
challenges,
several
techniques
developed.
Based
on
differences
engineering
methods,
this
review
proposes
three
strategies:
engineering-based
capsid
modification
(capsid
modification),
surface
tethering
through
chemical
conjugation
(surface
tethering),
other
formulations
loaded
(virus
load).
advantages
encountered
strategies
summarized.
Keywords:
engineering,
modification,
tethering,
load,
rational
design,
directed
evolution,
machine
learning
This
research
investigated
the
usefulness
of
magnetic
iron
oxide
nanoparticles
(Fe3O4)
as
a
support
to
immobilize
lipase
Eversa
Transform
2.0
(ET
2.0)
obtain
an
active
and
stable
biocatalyst,
easily
recoverable
from
reaction
medium
for
applications
in
production
biodiesel.
Biodiesel
was
alternative
fuel
composed
mainly
fatty
acid
esters
with
strong
transesterification
esterification
capabilities.
The
study
focused
on
oleic
ethanol
synthesize
ethyl
oleate.
Magnetic
were
prepared
by
coprecipitation,
then
activated
glutaraldehyde
functionalized
γ-aminopropyltriethoxysilane
(APTES).
optimal
conditions
immobilizing
ET
pH
10,
25
mM
sodium
carbonate
buffer,
enzymatic
load
200
U/g,
1
h
contact
time,
obtaining
78%
yield
activity
205.9
U/g.
Postimmobilization
evaluation
showed
that
immobilized
enzyme
performed
better
than
its
free
form.
Kinetic
studies
conducted
under
these
optimized
(2–96
at
150
rpm
37
°C).
biocatalyst
tested
synthesis
oleate
using
substrate
ethanol,
achieving
conversion
88.1%.
Subsequent
recirculation
tests
maintained
approximately
80%
until
fourth
cycle,
confirming
sustainability
ester
production.
Molecular
docking
revealed
binding
affinity
enzyme-docked
oil
composition
estimated
−5.8
kcal/mol,
suggesting
combination
suitable
esterification.
