The Aging Heart in Focus: The Advanced Understanding of Heart Failure with Preserved Ejection Fraction

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102542 - 102542

Опубликована: Окт. 12, 2024

Язык: Английский

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Risk factor of postoperative pulmonary complications after colorectal cancer surgery: an analysis of nationwide inpatient sample

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 21, 2025

To investigate the incidence rate, risk factors, and clinical implications of postoperative pulmonary complications (PPCs) in patients undergoing colorectal cancer surgery (CRC). The study extracted data from National Inpatient Sample (NIS) between 2010 2019. Patients' were analyzed to identify predictors PPCs, association possible factors PPCs also assessed. A total 169,067 CRC included 15,494 (9.16%) diagnosed with study. Our found that age, gender, number comorbidities, type location hospital, certain preoperative such as fluid electrolyte disorders (odd ratio [OR] 2.53), coagulopathy (OR 2.16), congestive heart failure 1.91), chronic disease 1.57) PPCs. In addition, complications, continuous mechanical ventilation 8.18), sepsis 4.46), deep vein thrombosis 4.17) shock 4.07) most important prolonged length hospital stay (14 days vs. 6 days) led a higher mortality rate (13.04% 1.20%). Optimizing perioperative care practices are essential steps reduce patients.

Язык: Английский

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SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established

Heart Failure Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract With rising incidence, mortality and limited therapeutic options, heart failure with preserved ejection fraction (HFpEF) remains one of the most important topics in cardiovascular medicine today. Characterised by left ventricular diastolic dysfunction partially due to impaired Ca 2+ homeostasis, ion channel particular, SarcoEndoplasmic Reticulum -ATPase (SERCA2a), may play a significant role its pathophysiology. A better understanding complex mechanisms interplaying contribute SERCA2a will help develop treatments targeting it thus address growing clinical challenge HFpEF poses. This review examines conflicting evidence present for changes expression activity HFpEF, explores potential underlying mechanisms, finally evaluates drug gene therapy trials failure. Recent positive results from involving widely used anti-diabetic agents such as sodium-glucose co-transporter protein 2 inhibitors (SGLT2i) glucagon-like peptide-1 (GLP-1) agonists offer advancement management. The interplay between these regulation presents novel angle that could open new avenues modulating function; however, mechanistic research this emerging field is limited. Overall, direct undetermined, highlighting need well-designed pre-clinical studies robust trials.

Язык: Английский

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A look at MERCs as UPR^mt regulatory hubs in age-associated heart diseases

The Journal of Cardiovascular Aging, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 22, 2025

With the increase in life expectancy globally, challenge of dealing with aging becomes more prominent. Aging is a risk factor for several diseases, including cardiovascular disease. Mitochondria, which have long been studied relation to aging, play crucial role maintaining cellular homeostasis. However, there limitation interorganellar communication as organisms age. The unfolded protein response mitochondria (UPRmt) activated during stress maintain mitochondrial homeostasis and prevent accumulation damaged mitochondria. This involves signaling from nucleus, leading transcriptional changes. In context heart, this review explores terms function morphology. It also discusses impact UPRmt on cardiac diseases such heart failure, acute myocardial infarction, dilated cardiomyopathy. highlights potential mitochondria-endoplasmic reticulum contact sites (MERCs) modulating aging. Finally, it provides an update molecules that induce activity, potentially benefiting

Язык: Английский

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Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 18, 2025

Background: Heart failure with preserved ejection fraction (HFpEF) is a systemic syndrome primarily associated fibrosis, oxidative stress, inflammation, and cellular apoptosis. Growth differentiation factor 15 (GDF15), biomarker commonly used in clinical studies, exhibits protective effects on the myocardium. Therefore, focus of present study to determine mechanism by which GDF15 protects cardiac function HFpEF. Methods: We conducted functional enrichment analysis protein-protein interaction network genes highly expressed HFpEF but lowly normal samples. established an rat model feeding rats high-fat diet administering N-omega-nitro-l-arginine-methyl ester (L-NAME) their drinking water silenced tail vein injection lentivirus (L3110). After 12 weeks feeding, echocardiographic examinations were performed. Following euthanasia rats, blood heart tissue samples collected. sections stained using Masson’s trichrome terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining methods. Western blot (WB) was employed concentrations relevant proteins. Results: The results showed that compared + MOCK group, HFpEF+silencing (siGDF15) group exhibited more severe dysfunction, significant decreases (p < 0.05) E/A ratio 0.001). WB demonstrated that, HFpEF+siGDF15 increased expression fibrosis-associated proteins, including collagen I 0.01), III α-smooth muscle actin (α-SMA) 0.01). Additionally, stress-associated biomarkers such as myeloperoxidase (MPO) 0.01) oxidized low-density lipoprotein (ox-LDL) inflammation-associated biomarkers, interleukin-1 beta (IL-1β) interleukin-6 (IL-6) interleukin-8 (IL-8) tumor necrosis α (TNFα) apoptosis-associated like cleaved caspase-3 BCL2-associated X (BAX) also upregulated group. Conclusions: Our research indicates preserves inhibiting myocardial reducing cell alleviating suppressing

Язык: Английский

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Heart Failure in Older Patients: An Update

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 1982 - 1982

Опубликована: Март 14, 2025

Heart failure (HF) is a clinical syndrome with high incidence and prevalence morbidity death rate, even in the short term, representing serious public health issue, mainly older people. It growing cause for hospital admission this age group, being frequently associated several comorbidities, further aggravating disease’s course. Moreover, HF patients are usually affected by conditions, like frailty, malnutrition, cachexia, which significantly impact overall management of need to be properly identified treated. Diagnosing managing may very complicated challenging. Although specific data on treatment both acute chronic subjects limited extrapolated from large-scale trials, standard pharmacological considered well-tolerated generally safe. In any case, personalized tailored approach mandatory based severity status, prognosis, above all frailer more comorbid subjects, due higher rate drug interactions, side effects, therapy discontinuation population. scenario, palliative care has become fundamental part elderly order improve their quality life. an increasing number promising options deserve investigation support clinicians optimizing patients. work, we provide detailed updated insight into clinical, therapeutic, prognostic features

Язык: Английский

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Insights into the role of obesity in Heart Failure with Preserved Ejection Fraction pathophysiology and management

Canadian Journal of Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Abstract Delaying senescence of cardiomyocytes has garnered widespread attention as a potential target for preventing cardiovascular diseases (CVDs). FGF13 (Fibroblast growth factor 13) been implicated in various pathophysiological processes. However, its role premature myocardial aging and cardiomyocyte remains unknown. Adeno‐associated virus 9 (AAV9) vectors expressing cardiac‐specific Fgf13 knockout (Fgf13KO) mice are utilized to reveal that overexpression deficiency exacerbated alleviated Doxorubicin/D‐galactose‐induced characteristics functional impairment, respectively. Transcriptomics employed identify an association between Caveolin‐1 (Cav1). Mechanistic studies indicated regulated the Cav1 promoter activity expression through p38/MAPK pathway nuclear translocation p65, well binding level PTRF mediate senescence. Furthermore, murine hearts reversed alleviatory effects on phenotype dysfunction. This study demonstrated Cav1‐p53‐p21 axis augment thereby cardiac suggests knockdown may be promising approach combat CVDs response chemotoxicity.

Язык: Английский

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Relationship between serum uric acid levels and uric acid lowering therapy with the prognosis of patients with heart failure with preserved ejection fraction: a meta-analysis

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Июнь 13, 2024

Aims This meta-analysis aimed to explore the association between serum uric acid levels and efficacy of acid-lowering therapies on clinical outcomes among patients with heart failure preserved ejection fraction (HFpEF). Methods A comprehensive literature search was conducted through October 21, 2023, across PubMed, Embase, Cochrane Library, Web Science databases. The pooled effect sizes were estimated presented their respective 95% confidence intervals (CI). Subgroup analyses based various factors, including sample size (&lt;1,000 vs. ≥1,000), follow-up duration (&lt;2 years ≥2 years), study quality (assessed by a score &lt;7 ≥7), ethnicity (Non-Asian Asian), design (prospective retrospective), type (HF) (acute chronic), presence hyperuricemia (yes or no), left ventricular (LVEF) thresholds (≥45% ≥50%), therapy (traditional novel). Results analysis included total 12 studies. Elevated significantly linked an increased risk all-cause mortality [relative (RR): 1.21, CI: 1.06–1.37, P = 0.004] cardiovascular (CV) (RR: 1.71, 1.42–2.04, &lt; 0.001) in HFpEF patients. confirmed this association, particularly non-Asian populations, those chronic HFpEF, studies two more. Additionally, higher associated HF-related hospitalization [hazard ratio (HR): 1.61, 1.12–2.34, 0.011]. Regarding treatment, did not show significant reducing However, it decreased due HF 0.85, 0.79–0.91, 0.001). Conclusion findings highlight prognostic significance suggest that may be beneficial incidence hospitalizations. Further research is warranted elucidate mechanisms which confers its potential benefits.

Язык: Английский

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Aging, Through Knowledge and Wisdom

Canadian Journal of Cardiology, Год журнала: 2024, Номер 40(8), С. 1375 - 1376

Опубликована: Июнь 18, 2024

Язык: Английский

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