Glycoside-Mediated Enhancement of Stability in Aluminum Oxyhydroxide Nanoadjuvants during Freeze-Drying DOI

Mudasira Bhurt,

Xin Li, Nan Zhang

и другие.

Langmuir, Год журнала: 2024, Номер 40(46), С. 24613 - 24621

Опубликована: Ноя. 6, 2024

Aluminum-based adjuvants have been indispensable to vaccine potency. However, their effectiveness is difficult maintain after freeze-drying, which limits the storage and application of aluminum-adjuvanted vaccines. In this study, impact freeze-drying on aluminum oxyhydroxide nanorods (AlOOH NRs) was investigated. Freeze-drying led aggregation resulted in loss surface hydroxyl content adjuvants. To alleviate freeze-drying-induced damage, potency different alkyl glycosides as protectants further evaluated. It demonstrated that structural balance head tail a glycoside more conducive protecting AlOOH NRs from groups. These results underline proper selection protect against functional defects caused by important for stability efficacy vaccines biopharmaceutical products.

Язык: Английский

Glycoside-Mediated Enhancement of Stability in Aluminum Oxyhydroxide Nanoadjuvants during Freeze-Drying DOI

Mudasira Bhurt,

Xin Li, Nan Zhang

и другие.

Langmuir, Год журнала: 2024, Номер 40(46), С. 24613 - 24621

Опубликована: Ноя. 6, 2024

Aluminum-based adjuvants have been indispensable to vaccine potency. However, their effectiveness is difficult maintain after freeze-drying, which limits the storage and application of aluminum-adjuvanted vaccines. In this study, impact freeze-drying on aluminum oxyhydroxide nanorods (AlOOH NRs) was investigated. Freeze-drying led aggregation resulted in loss surface hydroxyl content adjuvants. To alleviate freeze-drying-induced damage, potency different alkyl glycosides as protectants further evaluated. It demonstrated that structural balance head tail a glycoside more conducive protecting AlOOH NRs from groups. These results underline proper selection protect against functional defects caused by important for stability efficacy vaccines biopharmaceutical products.

Язык: Английский

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