Scandinavian Journal of Gastroenterology,
Год журнала:
2024,
Номер
59(6), С. 730 - 736
Опубликована: Март 1, 2024
Background
Hepatocellular
carcinoma
(HCC)
is
the
most
malignant
cancer
worldwide.
Sorafenib
(SRF)
a
common
therapeutic
drug
used
for
patients
with
advanced
HCC.
Nevertheless,
resistance
frequently
occurs
in
treated
sorafenib.
Glycyrrhizic
acid
(GRA)
natural
compound
that
identified
to
exhibit
anti-cancer
effects.
In
this
work,
we
aimed
investigate
effects
of
GRA
on
SRF-resistant
HCC
cells
and
potential
regulatory
mechanisms.
Hepatocellular
carcinoma
(HCC)
is
a
lethal
and
aggressive
human
malignancy.
The
present
study
examins
the
anti-tumor
effects
of
deubiquitylating
enzymes
(DUB)
inhibitors
in
HCC.
It
found
that
inhibitor
ubiquitin
specific
peptidase
8
(USP8)
DUB-IN-3
shows
most
effective
anti-cancer
responses.
Targeting
USP8
inhibits
proliferation
HCC
induces
cell
ferroptosis.
In
vivo
xenograft
metastasis
experiments
indicate
inhibition
suppresses
tumor
growth
lung
metastasis.
treatment
or
depletion
decrease
intracellular
cystine
levels
glutathione
biosynthesis
while
increasing
accumulation
reactive
oxygen
species
(ROS).
Mechanistical
studies
reveal
stabilizes
O-GlcNAc
transferase
(OGT)
via
inhibiting
K48-specific
poly-ubiquitination
process
on
OGT
protein
at
K117
site,
STE20-like
kinase
(SLK)-mediated
S716
phosphorylation
required
for
interaction
with
OGT.
Most
importantly,
O-GlcNAcylates
solute
carrier
family
7,
member
11
(SLC7A11)
Ser26
cells,
which
essential
SLC7A11
to
import
from
extracellular
environment.
Collectively,
this
demonstrates
pharmacological
knockout
can
inhibit
progression
induce
ferroptosis
decreasing
stability
OGT,
imposes
great
challenge
targeting
potential
approach
treatment.
Cancer Gene Therapy,
Год журнала:
2024,
Номер
31(8), С. 1105 - 1112
Опубликована: Март 18, 2024
Abstract
Hepatocellular
Carcinoma
(HCC)
is
one
of
the
most
common
types
primary
liver
cancer.
Current
treatment
options
have
limited
efficacy
against
this
malignancy,
primarily
owing
to
difficulties
in
early
detection
and
inherent
resistance
existing
drugs.
Tumor
heterogeneity
a
pivotal
factor
contributing
significantly
recurrent
manifestations
HCC.
Intratumoral
an
important
aspect
spectrum
complex
tumor
contributes
late
diagnosis
failure.
Therefore,
it
crucial
thoroughly
understand
molecular
mechanisms
how
develops.
This
review
aims
summarize
possible
dimensions
with
emphasis
on
intratumoral
heterogeneity,
evaluate
its
profound
impact
therapeutic
strategies
for
HCC,
explore
suitability
appropriate
pre-clinical
models
that
can
be
used
best
study
heterogeneity;
thus,
opening
new
avenues
cancer
treatment.
Background
—Standard
treatment
of
inoperable
hepatocellular
carcinoma
has
not
been
established.
Somatostatin
shown
to
possess
antimitotic
activity
against
a
variety
non-endocrine
tumours.
Aims
—To
assess
the
presence
somatostatin
receptors
in
human
liver
and
treat
advanced
with
analogue,
octreotide.
Methods
—Somatostatin
were
measured
tissue
homogenates
from
patients
acute
chronic
hepatitis,
cirrhosis,
carcinoma.
Fifty
eight
randomised
receive
either
subcutaneous
octreotide
250
μg
twice
daily,
or
no
treatment.
Groups
comparable
respect
age,
sex,
Okuda
classification,
biochemistry
virology.
Results
—Various
amounts
identified
all
including
those
Treated
had
an
increased
median
survival
(13
months
versus
four
months,
p=0.002,
log
rank
test)
cumulative
rate
at
six
12
(75%
37%,
56%
13%
respectively).
Octreotide
administration
significantly
reduced
α
fetoprotein
levels
months.
When
multivariable
Cox’s
proportional
hazards
model
was
fitted,
variables
associated
were:
administration,
absence
serum
albumin,
small
clearly
lower
hazard
(0.383)
multivariate
analysis.
Conclusions
—Octreotide
improves
is
valuable
alternative
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(2), С. 277 - 287
Опубликована: Янв. 26, 2024
The
intricate
molecular
landscape
of
cancer
pathogenesis
continues
to
captivate
researchers
worldwide,
with
Circular
RNAs
(circRNAs)
emerging
as
pivotal
players
in
the
dynamic
regulation
biological
functions.
study
investigates
elusive
link
between
circRNAs
and
Transforming
Growth
Factor-β
(TGF-β)
signalling
pathway,
exploring
their
collective
influence
on
progression
metastasis.
Our
comprehensive
investigation
begins
by
profiling
circRNA
expression
patterns
diverse
types,
revealing
a
repertoire
intricately
linked
TGF-β
pathway.
Through
integrated
bioinformatics
analyses
functional
experiments,
we
elucidate
specific
circRNA-mRNA
interactions
that
modulate
signalling,
unveiling
regulatory
controls
governing
this
crucial
Furthermore,
provide
compelling
evidence
impact
circRNA-mediated
modulation
key
cellular
processes,
including
epithelial-mesenchymal
transition
(EMT),
migration,
cell
proliferation.
In
addition
mechanistic
roles,
have
shown
promise
diagnostic
prognostic
biomarkers,
well
potential
targets
for
therapy.
Their
ability
critical
pathways,
such
axis,
underscores
significance
biology
clinical
applications.
interplay
is
dissected,
uncovering
novel
circuits
contribute
complexity
biology.
This
review
unravels
previously
unexplored
dimension
carcinogenesis,
emphasizing
role
shaping
landscape.
Journal of Cancer,
Год журнала:
2024,
Номер
15(13), С. 4219 - 4231
Опубликована: Янв. 1, 2024
Hepatocellular
carcinoma
(HCC),
the
predominant
malignancy
of
digestive
tract,
ranks
as
third
most
common
cause
cancer-related
mortality
globally,
significantly
impeding
human
health
and
lifespan.
Emerging
immunotherapeutic
approaches
have
ignited
fresh
optimism
for
patient
outcomes.
This
investigation
probes
link
between
731
immune
cell
phenotypes
HCC
through
Mendelian
Randomization
single-cell
sequencing,
aiming
to
unearth
viable
drug
targets
dissect
HCC's
etiology.
Physiology,
Год журнала:
2024,
Номер
40(1), С. 000 - 000
Опубликована: Июль 30, 2024
Inflammation
is
an
important
physiological
response
of
the
organism
to
restore
homeostasis
upon
pathogenic
or
damaging
stimuli.
However,
persistence
harmful
trigger
a
deficient
resolution
process
can
evolve
into
state
low-grade,
chronic
inflammation.
This
condition
strongly
associated
with
development
several
increasingly
prevalent
and
serious
conditions,
such
as
obesity,
cancer,
cardiovascular
diseases,
elevating
overall
morbidity
mortality
worldwide.
The
current
pandemic
diseases
underscores
need
address
inflammation,
its
mechanisms,
potential
preventive
measures
limit
widespread
impact.
present
review
discusses
knowledge
research
gaps
regarding
association
between
low-grade
inflammation
focusing
on
digestive
cancer.
We
examine
art
in
selected
aspects
topic
propose
future
directions
approaches
for
field.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 731 - 731
Опубликована: Фев. 5, 2024
The
present
work
aimed
to
study
the
feasibility
of
Angelica
sinensis
polysaccharide
(ASP)
as
an
instinctive
liver
targeting
drug
delivery
carrier
for
oridonin
(ORI)
in
treatment
hepatocellular
carcinoma
(HCC).
ASP
was
reacted
with
deoxycholic
acid
(DOCA)
via
esterification
reaction
form
ASP-DOCA
conjugate.
ORI-loaded
nanoparticles
(ORI/ASP-DOCA
NPs)
were
prepared
by
thin-film
water
method,
and
their
size
about
195
nm
aqueous
solution.
ORI/ASP-DOCA
NPs
had
a
loading
capacity
up
9.2%.
release
ORI
pH-dependent,
resulting
rapid
decomposition
accelerated
at
acidic
pH.
significantly
enhanced
accumulation
tumors
through
ASGPR-mediated
endocytosis.
In
vitro
results
showed
that
increased
cell
uptake
apoptosis
HepG2
cells,
vivo
caused
effective
tumor
suppression
H22
tumor-bearing
mice
compared
free
ORI.
short,
might
be
simple,
feasible,
safe
nano-drug
system
could
used
targeted
tumors.
