International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 1996 - 1996
Опубликована: Фев. 7, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
liver
tumor
and
associated
with
high
mortality
rates.
Approximately
80%
of
cases
occur
in
cirrhotic
livers,
posing
a
significant
challenge
for
appropriate
therapeutic
management.
Adequate
screening
programs
high-risk
groups
are
essential
early-stage
detection.
The
extent
extrahepatic
spread
hepatic
functional
reserve
recognized
as
two
influential
prognostic
factors.
In
this
retrospective
multicenter
study,
we
utilized
machine
learning
(ML)
methods
to
analyze
predictors
at
time
diagnosis
total
208
patients.
eXtreme
gradient
boosting
(XGB)
method
achieved
highest
values
identifying
key
factors
HCC
diagnosis.
etiology
was
found
be
variable
strongly
poorer
prognosis.
widely
used
Barcelona
Clinic
Liver
Cancer
(BCLC)
classification
our
setting
demonstrated
superiority
over
TNM
classification.
Although
alpha-fetoprotein
(AFP)
remains
commonly
biological
marker,
elevated
levels
did
not
correlate
reduced
survival.
Our
findings
suggest
need
explore
new
biomarkers
individualized
management
these
Journal of Cancer Research and Therapeutics,
Год журнала:
2025,
Номер
21(2), С. 465 - 476
Опубликована: Май 1, 2025
ABSTRACT
Background:
Ferroptosis
can
have
a
major
impact
on
the
development
and
advancement
of
hepatocellular
carcinoma
(HCC)
due
to
its
clear
association
with
heightened
vulnerability
disease.
This
study
aimed
develop
novel
nanoplatform
evaluate
effectiveness
in
vivo
vitro
models
HCC.
Methods:
Erastin,
compound
that
induces
iron-dependent
cell
death,
HMME,
sonosensitizer,
were
enclosed
within
mesoporous
silica
nanoparticles
(MSNs).
The
engineered
exhibit
responsive
assembly-disassembly
mechanism.
Hydrophilic
hyaluronic
acid
(HA)
was
utilized
for
conjugation
modification
synthesize
Erastin/HMME@MSNs-HA.
In
experiments
conducted
elucidate
antitumor
mechanisms
this
nanomaterial.
Results:
cellular
experiments,
Erastin/HMME@MSNs-HA
rapidly
degraded
by
hyaluronidase,
leading
increased
endocytosis
cancer
cells.
Cellular
breakdown
led
generation
harmful
reactive
oxygen
species
(ROS),
decreased
glutathione
levels,
lipid
peroxidation,
resulting
decrease
mitochondrial
membrane
potential,
dysfunctional
mitochondria,
reduced
growth,
death.
Additionally,
nanotherapy
platform,
when
combined
ultrasound
(US)
treatment,
exhibited
significant
therapeutic
against
tumors
.
It
induced
death
cancerous
tissues,
tumor
worsened
tissue
deprivation,
good
compatibility
body.
Conclusion:
These
findings
indicate
effectively
alleviate
hypoxia
while
inducing
apoptosis
ferroptosis,
laying
foundation
enhancing
efficacy
ROS-mediated
HCC
therapy.
ONCOLOGIE,
Год журнала:
2023,
Номер
26(1), С. 91 - 103
Опубликована: Ноя. 8, 2023
Abstract
Objectives
Immune-related
genes
(IRGs)
in
hepatocellular
carcinoma
(HCC)
are
significantly
associated
with
both
tumor-infiltrating
immune
cells
(TICs)
and
disease
prognosis.
Therefore,
exploring
the
correlation
between
IRGs
HCC
its
related
mechanism
will
provide
new
evidence
for
diagnosis
treatment
of
HCC.
Methods
The
current
paper
analyzed
TICs
374
samples
retrieved
from
TCGA-LIHC
dataset
using
ssGSEA
divided
them
according
to
level
cell.
A
total
177
differentially
expressed
(DEGs)
were
by
protein-protein
interaction
(PPI)
networks
univariate
multivariate
Cox
regression
analyses.
Results
Four
(C7,
CTSV,
MMP1,
VCAN)
found
be
indicators
prognosis
PPI
network
analyses
DEGs,
which
was
independently
validated
an
external
dataset.
risk
model
constructed
factors
dependent
on
four
IRGs.
Prognostic
subtype
infiltrating
cells.
Conclusions
effective
identified
as
novel
independent
prognostic
that
correlated
tumor
infiltration
This
signature
may
guide
choice
immunotherapy
Pharmacological Research,
Год журнала:
2023,
Номер
192, С. 106789 - 106789
Опубликована: Май 4, 2023
Oral
multitarget
tyrosine
kinase
inhibitors
(TKIs),
such
as
sorafenib,
which
suppress
tumor
cell
proliferation
and
angiogenesis,
have
been
approved
to
treat
patients
with
hepatocellular
carcinoma
(HCC).
Of
note,
only
approximately
30%
of
can
benefit
from
TKIs,
this
population
usually
acquires
drug
resistance
within
6
months.
In
study,
we
intended
explore
the
mechanism
associated
regulating
sensitivity
HCC
TKIs.
We
revealed
that
integrin
subunit
β
5
(ITGB5)
is
abnormally
expressed
in
contributes
decreased
sorafenib.
Mechanistically,
unbiased
mass
spectrometry
analysis
using
ITGB5
antibodies
interacts
EPS15
prevent
degradation
EGFR
cells,
activates
AKT-mTOR
signaling
MAPK
pathway
reduce
cells
addition,
showed
CSNK1A1
binds
cells.
Further
study
indicated
increased
protein
level
through
EGFR-AKT-mTOR
HCC.
Upregulated
phosphorylates
enhance
interaction
between
activate
Thus,
identified
a
positive
feedback
loop
ITGB5-EPS15-EGFR-CSNK1A1
This
finding
provides
theoretical
basis
for
future
development
therapeutic
strategies
improve
anti-HCC
efficacy
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 1996 - 1996
Опубликована: Фев. 7, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
liver
tumor
and
associated
with
high
mortality
rates.
Approximately
80%
of
cases
occur
in
cirrhotic
livers,
posing
a
significant
challenge
for
appropriate
therapeutic
management.
Adequate
screening
programs
high-risk
groups
are
essential
early-stage
detection.
The
extent
extrahepatic
spread
hepatic
functional
reserve
recognized
as
two
influential
prognostic
factors.
In
this
retrospective
multicenter
study,
we
utilized
machine
learning
(ML)
methods
to
analyze
predictors
at
time
diagnosis
total
208
patients.
eXtreme
gradient
boosting
(XGB)
method
achieved
highest
values
identifying
key
factors
HCC
diagnosis.
etiology
was
found
be
variable
strongly
poorer
prognosis.
widely
used
Barcelona
Clinic
Liver
Cancer
(BCLC)
classification
our
setting
demonstrated
superiority
over
TNM
classification.
Although
alpha-fetoprotein
(AFP)
remains
commonly
biological
marker,
elevated
levels
did
not
correlate
reduced
survival.
Our
findings
suggest
need
explore
new
biomarkers
individualized
management
these
