Study of CD4+ T-lymphocytes in chronic kidney disease patients with COVID-19 infection
Egyptian journal of Immunology,
Год журнала:
2024,
Номер
31(01), С. 155 - 161
Опубликована: Янв. 1, 2024
Chronic
kidney
disease
(CKD)
is
a
functional
and/or
structural
damage
that
lasts
more
than
three
months
duration.
This
study
aimed
to
analyze
CD4+
T-lymphocytes
levels
in
chronic
CKD
patients
specifically,
during
the
coronavirus
2019
(COVID-19)
pandemic
assess
adaptive
cell-mediated
immunity.
The
measured
absolute
counts
by
flowcytometry
among
participating
individuals.
included
146
subjects,
40
and
tested
positive
for
COVID-19,
44
negative
COVID-19
62
normal
individuals
as
controls.
There
was
significant
impact
of
infection
showing
lower
values
six
folds
compared
control
(Odds
Ratio:
72.63,
p=
0.0001).
Also,
there
correlation
between
decrease
advanced
stages
CKD.
Therefore,
indicated
causes
an
obvious
alteration
body
immune
system
decreased
alongside
with
stages.
While
exposes
be
50%
likely
express
patients.
In
conclusion,
poor
response
increased
morbidity
mortality
could
correlated
especially
when
associated
comorbidity.
Язык: Английский
Adaptive Immune Dysfunction in Covid-19 Patients with Liver Injury During the Omicron Surge
Опубликована: Янв. 1, 2024
Язык: Английский
Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach
Li Wang,
Anning Chen,
Lantian Zhang
и другие.
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Июль 4, 2024
Background
The
ongoing
global
health
crisis
of
COVID-19,
and
particularly
the
challenges
posed
by
recurrent
infections
Omicron
variant,
have
significantly
strained
healthcare
systems
worldwide.
There
is
a
growing
body
evidence
indicating
an
increased
susceptibility
to
infection
in
patients
suffering
from
Acute
Kidney
Injury
(AKI).
However,
intricate
molecular
interplay
between
AKI
variant
COVID-19
remains
largely
enigmatic.
Methods
This
study
employed
comprehensive
analysis
human
RNA
sequencing
(RNA-seq)
microarray
datasets
identify
differentially
expressed
genes
(DEGs)
associated
with
context
AKI.
We
engaged
functional
enrichment
assessments,
examination
Protein-Protein
Interaction
(PPI)
networks,
advanced
network
elucidate
cellular
signaling
pathways
involved,
critical
hub
genes,
determine
relevant
controlling
transcription
factors
microRNAs.
Additionally,
we
explored
protein-drug
interactions
highlight
potential
pharmacological
interventions.
Results
Our
investigation
revealed
significant
DEGs
implicated
both
identified
pivotal
including
EIF2AK2,
PLSCR1,
GBP1,
TNFSF10,
C1QB,
BST2,
their
regulatory
Notably,
murine
model,
there
was
marked
reduction
EIF2AK2
expression,
contrast
elevations
BST2.
exhibited
inverse
relationship
primary
mediator,
Kim-1,
whereas
PLSCR1
C1QB
demonstrated
strong
positive
correlations
it.
Moreover,
therapeutic
agents
such
as
Suloctidil,
Apocarotenal,
3′-Azido-3′-deoxythymidine,
among
others.
findings
also
highlighted
correlation
diseases
like
myocardial
ischemia,
schizophrenia,
liver
cirrhosis.
To
further
validate
credibility
our
data,
independent
validation
dataset
verify
genes.
expression
patterns
were
consistent
research
findings,
reaffirming
reliability
results.
Conclusion
bioinformatics
has
provided
initial
insights
into
shared
genetic
landscape
AKI,
identifying
targets
drugs.
preliminary
lays
foundation
for
research,
hope
contributing
development
innovative
treatment
strategies
these
complex
medical
conditions.
Язык: Английский
Immunophenotyping characteristics and clinical outcome of COVID-19 patients treated with azvudine during the Omicron surge
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 25, 2024
Little
is
known
about
immunophenotyping
characteristics
and
clinical
outcomes
of
COVID-19
patients
treated
with
azvudine
during
the
Omicron
variant
surge.
This
study
enrolled
diagnosed
from
December
2022
to
February
2023.
The
primary
outcome
was
defined
as
all-cause
mortality,
along
a
composite
reflecting
disease
progression.
were
followed
for
period
60
days
their
admission.
A
total
268
in
this
retrospective
study.
found
that
counts
lymphocyte
subsets
significantly
reduced
mortality
groups
compared
non-composite
discharge
(all
p
<
0.001).
Correlation
analysis
revealed
negative
association
between
cell
inflammatory
markers
levels.
receiver
operating
characteristic
(ROC)
curve
identified
low
CD4+
T
count
most
significant
predictor
progression
among
various
subsets.
Additionally,
both
Kaplan-Meier
multivariate
regression
demonstrated
level
(<
156.00
cells/μl)
closely
associated
azvudine.
may
serve
predictive
indicator
identifying
receiving
treatment
who
are
at
an
elevated
risk
experiencing
adverse
outcomes.
These
findings
offer
valuable
insights
physicians
optimizing
administration
Язык: Английский
Immunophenotyping characteristics and outcome of COVID‐19 patients: peripheral blood CD8+T cell as a prognostic biomarker for patients with Nirmatrelvir
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 20, 2023
Nirmatrelvir
has
been
authorized
for
the
treatment
of
both
hospitalized
and
non-hospitalized
COVID-19
patients.
However,
association
between
T
lymphocyte
subsets
outcome
patients
treated
with
oral
not
investigated.
The
objective
this
study
was
to
examine
whether
could
serve
as
biomarkers
assess
risk
mortality
in
undergoing
treatment,
aim
enhancing
medication
management
patients.We
conducted
a
retrospective
cohort
at
Xiangya
Hospital
Central
South
University
China
December
5,
2022
January
31,
2023.
reported
demographic,
clinical,
subsets,
inflammatory
cytokine
data
We
evaluated
associations
on
admission
composite
or
death
using
univariate
multivariable
Cox
regression
analyses
hazards
ratios
(HRs)
95%
confidence
intervals
(CIs).We
identified
2118
during
period,
follow-up
up
38
days.
Of
these,
131
received
Nirmatrelvir,
56
(42.7%)
group,
75
(57.3%)
non-composite
group.
Additionally,
101
(77.1%)
were
discharged,
while
30
(22.9%)
died.
Our
results
showed
significant
decrease
CD3+,
CD4+,
CD8+
cell
counts
group
compared
discharged
respectively.
Multivariate
analysis
that
count
peripheral
blood
independently
associated
an
HR
1.96
(95%CI:
1.01-3.80).
CD4+
increased
hazard
developing
mortality,
HRs
6.48
1.47-28.63)
3.75
1.27-11.11),
respectively.Our
revealed
positive
correlation
progression
Nirmatrelvir.
Lower
(/μL)
(<201)
higher
in-hospital
severity
death.
findings
may
provide
valuable
references
physicians
optimizing
use
Язык: Английский