PANoptosis: Mechanisms, biology, and role in disease

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 246 - 262

Опубликована: Окт. 12, 2023

Summary Cell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which mediated by multifaceted PANoptosome complexes assembled via integrating components from other modalities. There growing interest in process function of PANoptosis. Accumulating evidence suggests that occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, cancer. Given impact across disease spectrum, this review briefly describes relationships highlights key molecules formation activation, outlines roles diseases together with potential therapeutic targeting. We also discuss important concepts pressing issues future research. Improved understanding its mechanisms crucial identifying novel targets strategies.

Язык: Английский

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PANoptosis: Emerging mechanisms and disease implications

Life Sciences, Год журнала: 2023, Номер 333, С. 122158 - 122158

Опубликована: Окт. 6, 2023

Язык: Английский

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Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity

Advanced Science, Год журнала: 2023, Номер 11(8)

Опубликована: Дек. 3, 2023

Abstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes external environmental cues. has significant physiological implications leads to distinct immunological outcomes. This review discusses the multifarious neutrophil pathways, including apoptosis, NETosis, pyroptosis, necroptosis, ferroptosis, outlines effects immune responses disease progression. Understanding multifaceted aspects death, intersections among signaling ramifications immunity will help facilitate development novel therapeutic methods.

Язык: Английский

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Characterization of PANoptosis-related genes in Crohn’s disease by integrated bioinformatics, machine learning and experiments

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 22, 2024

Currently, the biological understanding of Crohn's disease (CD) remains limited. PANoptosis is a revolutionary form cell death reported to participate in numerous diseases, including CD. In our study, we aimed uncover roles Differentially expressed PANoptosis-related genes (DE-PRGs) were identified by overlapping and differentially between CD normal samples combined microarray dataset. Three machine learning algorithms adopted detect hub DE-PRGs. To stratify heterogeneity within patients, nonnegative matrix factorization clustering was conducted. terms immune landscape analysis, "ssGSEA" method applied. qRT-PCR performed examine expression levels DE-PRGs patients colitis model mice. Ten with satisfactory diagnostic performance validated: CD44, CIDEC, NDRG1, NUMA1, PEA15, RAG1, S100A8, S100A9, TIMP1 XBP1. These displayed significant associations certain types CD-related genes. We also constructed gene‒microRNA, gene‒transcription factor drug‒gene interaction networks. classified into two patterns according Our results suggest that plays nonnegligible role modulating system interacting

Язык: Английский

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PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 31, 2024

PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.

Язык: Английский

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Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine

Trends in Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

IFI27, an interferon (IFN)-stimulated gene, is emerging as a crucial player in immune responses across various species, with significant implications for precision medicine. Commonly found among the most upregulated genes infections, cancers, well inflammatory and autoimmune disorders, IFI27 ready to be trialed clinical practice certain indications, holds promise immunomodulatory target. We hypothesize that plays dual role, typically supporting defense but sometimes contributing disease progression, which might render it putative biomarker diagnosis, prognosis, treatment response. advocate focused research on unlock its potential medicine contribute unifying framework of mechanisms Our viewpoint supported by numerous studies highlighting IFI27's involvement conditions possibilities application.

Язык: Английский

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PANoptosis, an indicator of COVID-19 severity and outcomes

Briefings in Bioinformatics, Год журнала: 2024, Номер 25(3)

Опубликована: Март 27, 2024

Abstract Coronavirus disease 2019 (COVID-19) has been wreaking havoc for 3 years. PANoptosis, a distinct and physiologically relevant inflammatory programmed cell death, perpetuates cytokine storm multi-organ injuries in COVID-19. Although PANoptosis performs indispensable roles host defense, further investigation is needed to elucidate the exact processes through which modulates immunological responses prognosis This study conducted bioinformatics analysis of online single-cell RNA sequence (scRNA-seq) bulk RNA-seq datasets explore potential as an indicator COVID-19 severity. The degree bronchoalveolar lavage fluid (BALF) peripheral blood mononuclear cells (PBMC) indicated severity Single-cell transcriptomics identified pro-inflammatory monocytes one primary sites subsequently demonstrated immune metabolic characteristics this group monocytes. In addition, illustrated that dexamethasone was likely alleviate inflammation by mitigating PANoptosis. Finally, showed PANoptosis-related genes could predict intensive care unit admission (ICU) outcomes patients who are hospitalized.

Язык: Английский

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Analysis of PANoptosis-related genes in septic cardiomyopathy by bioinformatics, machine learning and experimental validation

Heliyon, Год журнала: 2025, Номер unknown, С. e42882 - e42882

Опубликована: Фев. 1, 2025

Язык: Английский

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Current Evidence and Therapeutic Implications of PANoptosis in Sepsis

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 2490 - 2504

Опубликована: Янв. 1, 2025

Язык: Английский

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Interleukin-6 in neuroimmunological disorders: Pathophysiology and therapeutic advances with satralizumab

Autoimmunity Reviews, Год журнала: 2025, Номер 24(7), С. 103826 - 103826

Опубликована: Май 3, 2025

Язык: Английский

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