Effects of macrophages in OSCC progression
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 14, 2025
Macrophages
are
crucial
immune
cells
within
the
tumor
microenvironment
(TME),
involved
in
regulating
proliferation,
invasion,
metastasis,
ECM
remodeling,
angiogenesis,
and
immunosuppression.
Although
more
experimental
evidence
clinical
data
indicate
that
macrophages
onset
progression
of
oral
squamous
cell
carcinoma
(OSCC),
exact
pathogenesis
OSCC
associated
with
has
not
been
fully
elucidated.
Enhanced
knowledge
molecular
mechanisms
involving
will
aid
creation
treatments
targeted
specifically
at
macrophages.
This
review
outlines
pro-tumoral
anti-tumoral
effects
OSCC,
emphasizing
interaction
between
It
can
provide
theoretical
basis
for
establishment
complex
regulatory
network
centered
on
explore
novel
therapeutic
strategies
OSCC.
Язык: Английский
New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 22, 2025
N6-methylation
is
a
modification
in
which
methyl
group
added
to
the
adenine
base
of
nucleotide.
This
crucial
for
controlling
important
functions
that
are
vital
gene
expression,
including
mRNA
splicing,
stability,
and
translation.
Due
its
intricate
participation
both
normal
cellular
processes
course
disease,
as
well
critical
role
determining
cell
fate,
N6-methyladenosine
(m
6
A)
alteration
has
recently
attracted
lot
interest.
The
formation
progression
many
diseases,
especially
cancer,
can
be
attributed
dysregulated
m
A
alteration,
cause
disturbances
variety
functions,
such
immunological
responses,
proliferation,
differentiation.
In
this
study,
we
examine
how
dysregulation
affects
hepatocellular
carcinoma
(HCC),
with
particular
emphasis
on
it
contributes
evasion
carcinogenesis.
We
also
investigate
potential
novel
therapeutic
target,
providing
new
perspectives
approaches
meant
enhance
clinical
results
patients
HCC.
Язык: Английский
m6A epitranscriptomic modification in hepatocellular carcinoma: implications for the tumor microenvironment and immunotherapy
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 17, 2025
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
primary
liver
malignancy
and
a
leading
cause
of
cancer-related
deaths
globally.
The
asymptomatic
progression
early-stage
HCC
often
results
in
diagnosis
at
advanced
stages,
significantly
limiting
therapeutic
options
worsening
prognosis.
Immunotherapy,
with
immune
checkpoint
inhibitors
(ICIs)
forefront,
has
revolutionized
treatment.
Nevertheless,
tumor
heterogeneity,
evasion,
presence
immunosuppressive
components
within
microenvironment
(TIME)
continue
to
compromise
its
efficacy.
Furthermore,
resistance
or
non-responsiveness
ICIs
some
patients
underscores
urgent
need
unravel
complexities
TIME
design
innovative
strategies
that
enhance
immunotherapeutic
outcomes.
Emerging
evidence
revealed
pivotal
role
N6-methyladenosine
(m6A),
prominent
RNA
methylation
modification,
shaping
HCC.
By
regulating
stability
translation,
m6A
influences
immune-related
factors,
including
cytokines
molecules.
This
modification
governs
PD-L1
expression,
facilitating
escape
contributing
against
ICIs.
Advances
this
field
have
also
identified
m6A-related
regulators
as
promising
biomarkers
for
predicting
immunotherapy
response
potential
targets
optimizing
treatment
review
examines
regulatory
mechanisms
HCC,
focus
on
impact
cells
cytokine
dynamics.
It
explores
targeting
pathways
improve
efficacy
outlines
emerging
directions
future
research.
These
insights
aim
provide
foundation
developing
novel
overcome
advance
Язык: Английский
Emerging importance of m6A modification in liver cancer and its potential therapeutic role
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2025,
Номер
unknown, С. 189299 - 189299
Опубликована: Март 1, 2025
Язык: Английский
RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
RNA
modifications
are
epigenetic
changes
that
alter
the
structure
and
function
of
molecules,
playing
a
crucial
role
in
onset,
progression,
treatment
cancer.
Immune
checkpoint
inhibitor
(ICI)
therapies,
particularly
PD-1
blockade
anti-CTLA-4
treatments,
have
changed
landscape
virous
cancers,
showing
great
potential
different
cancer
patients,
but
sensitivity
to
these
therapies
is
limited
certain
individuals.
This
review
offers
comprehensive
survey
functions
therapeutic
implications
four
principal
modifications,
highlighting
significance
m6A
realms
immune
cells
tumor
immunotherapy.
starts
by
providing
foundational
summary
roles
assume
within
cell
community,
focusing
on
T
cells,
NK
macrophages,
dendritic
cells.
We
then
discuss
how
influence
intricate
regulatory
mechanisms
governing
expression,
modulation
ICI
efficacy,
prediction
outcomes,
drug
targeting
genes
regulated
modifications.
Finally,
we
explore
gene
editing,
vaccines,
adoptive
offering
valuable
insights
into
use
Язык: Английский
Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)
International Journal of Oncology,
Год журнала:
2024,
Номер
65(4)
Опубликована: Сен. 5, 2024
Hepatocellular
carcinoma
(HCC)
tissue
is
rich
in
dendritic
cells,
T
B
macrophages,
natural
killer
cells
and
cellular
stroma.
Together
they
form
the
tumor
microenvironment
(TME),
which
also
numerous
cytokines.
Tumor‑associated
macrophages
(TAMs)
are
involved
regulation
of
development.
TAMs
HCC
receive
stimuli
different
directions,
polarize
directions
release
cytokines
to
regulate
development
HCC.
mostly
divided
into
two
cell
phenotypes:
M1
M2.
secrete
pro‑inflammatory
mediators,
M2
a
variety
anti‑inflammatory
pro‑tumorigenic
substances.
The
TAM
polarization
tumors
Both
direct
indirect
methods
for
discussed.
indirectly
support
by
promoting
peripheral
angiogenesis
regulating
immune
TME.
In
terms
between
present
review
mainly
focuses
on
molecular
mechanism.
both
proliferation
apoptosis
quantitative
changes
HCC,
stimulate
related
invasive
migratory
ability
stemness
cells.
aims
identify
immunotherapeutic
options
based
mechanisms
TME
Язык: Английский
HMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2024,
Номер
150(10)
Опубликована: Окт. 28, 2024
Tumor
recurrence
after
radiofrequency
ablation
(RFA)
affects
the
survival
rate
of
patients
and
limits
its
clinical
application.
around
area
may
be
related
to
thermal
injury
hepatocytes
(HCs)
tumor,
but
specific
mechanism
is
still
unclear.
A
liver
cancer
mouse
model
was
established
via
RFA
in
C57BL/6
mice.
Primary
HCs
Kupffer
cells
(KCs)
were
isolated
cultured
assess
their
sensitivity
MTT
assay.
Flow
cytometry
used
macrophage
polarization.
Furthermore,
Western
blotting
co-immunoprecipitation
(co-IP)
utilized
evaluate
protein
expression
intracellular
signaling
pathway.
Finally,
Transwell
wound
healing
assays
conducted
invasion
potential
cells.
Our
findings
revealed
that
RFA-induced
promoted
upregulation
secretion
HMGB1
HCs.
had
a
protective
effect
on
injury,
potentially
mediated
through
autophagy
regulation.
Heat-injured
release
HMGB1,
which
activates
TREM1/JAK2/STAT3
pathway
KCs,
thus
fostering
an
immunosuppressive
tumor
microenvironment
(TME).
Moreover,
by
heat-injured
exacerbates
migration
HCC
influencing
triggers
from
HCs,
driving
M2
polarization
increasing
ability
These
reveal
therapeutic
target
for
combating
following
ablation.
Язык: Английский