Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder
Neurobiology of Stress,
Год журнала:
2024,
Номер
32, С. 100662 - 100662
Опубликована: Июль 25, 2024
Traumatic
experiences
result
in
the
development
of
posttraumatic
stress
disorder
(PTSD)
10-25%
exposed
individuals.
While
human
clinical
studies
suggest
that
susceptibility
is
potentially
linked
to
endocannabinoid
(eCB)
signaling,
neurobiological
PTSD
factors
are
poorly
understood.
Employing
a
rat
model
contextual
conditioned
fear,
we
characterized
distinct
resilient
and
susceptible
subpopulations
based
on
lasting
generalized
core
symptom
PTSD.
In
these
groups,
assessed
i.)
eCB
levels
by
mass
spectrometry
ii.)
expression
variations
system-
iii.)
neuroplasticity-related
genes
real-time
quantitative
PCR
circuitry
relevant
trauma-induced
changes.
Furthermore,
employing
unsupervised
semi-supervised
machine
learning
statistical
analytical
models,
iv.)
gene
patterns
with
most
robust
predictive
power
regarding
susceptibility.
According
our
findings,
model,
fear
responses
occurred
sufficient
variability
characterize
subpopulations.
Resilient
subjects
showed
elevated
prelimbic
lower
ventral
hippocampal
2-arachidonoyl-glycerol
(2-AG)
compared
non-shocked
control
subjects.
Ventral
2-AG
content
positively
correlated
strength
generalization.
was
associated
prefrontal,
amygdalar
neuronal
hypoactivity,
marked
decrease
transcription
modulating
neuroplasticity
an
altered
pattern
eCB-related
genes,
including
enzymes
involved
metabolism.
Unsupervised
approaches
highlighted
possess
strong
Taken
together,
changes
individuals
abnormal
activity
possibly
contribute
context
coding
deficits,
resulting
fear.
Язык: Английский
How Veterans with Chronic Pain Approach Using Cannabis for Symptom Management: Results from a Qualitative Interpretive Description Study
Cannabis and Cannabinoid Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Veterans
use
cannabis
as
a
chronic
pain
treatment
due
to
combination
of
the
easing
restrictions
and
dissatisfaction
with
care
standards.
The
segregation
medical
from
conventional
health
systems
may
translate
opportunities
disadvantages
that
are
not
well
defined.
Our
study
aimed
characterize
how
approach
using
for
symptom
management,
including
product
access,
developing
plan,
its
integration
into
daily
life.
Язык: Английский
Cannabis Research and Therapeutics: An International Quasi-experiment in Cannabis Policy
Clinical Therapeutics,
Год журнала:
2023,
Номер
45(6), С. 488 - 493
Опубликована: Июнь 1, 2023
Язык: Английский
Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 7, 2024
Abstract
Traumatic
experiences
result
in
the
development
of
posttraumatic
stress
disorder
(PTSD)
10-25%
exposed
individuals.
While
human
clinical
studies
suggest
that
susceptibility
is
potentially
linked
to
endocannabinoid
(eCB)
signaling,
neurobiological
PTSD
factors
are
poorly
understood.
Employing
a
rat
model
PTSD,
we
characterized
distinct
resilient
and
susceptible
subpopulations
based
on
generalized
fear,
core
symptom
PTSD.
In
these
groups,
assessed
i.)
eCB
levels
by
mass
spectrometry
expression
variations
system-
iii.)
neuroplasticity-related
genes
real-time
quantitative
PCR
circuitry
relevant
trauma-induced
changes.
Furthermore,
employing
supervised
semi-supervised
machine
learning
statistical
analytical
models,
iv.)
gene
patterns
with
most
robust
predictive
power
regarding
susceptibility.
According
our
findings,
model,
fear
responses
occurred
sufficient
variability
characterize
subpopulations.
Susceptible
subjects
showed
lower
prelimbic
higher
ventral
hippocampal
2-arachidonoyl-glycerol
(2-AG)
compared
subjects.
Ventral
2-AG
content
positively
correlated
strength
generalization.
was
associated
neuronal
prefrontal,
amygdalar
hypoactivity,
ii.)
marked
decrease
transcription
modulating
neuroplasticity
an
altered
pattern
eCB-related
genes,
including
enzymes
involved
metabolism.
Unsupervised
approaches
highlighted
possess
strong
Taken
together,
changes
individuals
abnormal
activity
possibly
contribute
context
coding
deficits,
resulting
fear.
Highlights
We
correlates
Posttrauma
separates
show
Neuroplasticity
predict
Язык: Английский
Pipe dreams: Cannabis legalization and the persistence of racial disparities in jail incarceration
Journal of Criminal Justice,
Год журнала:
2024,
Номер
94, С. 102230 - 102230
Опубликована: Июль 24, 2024
Язык: Английский
Knowledge and Attitudes of Cannabidiol in Croatia among Students, Physicians, and Pharmacists
Pharmacy,
Год журнала:
2023,
Номер
12(1), С. 2 - 2
Опубликована: Дек. 23, 2023
Due
to
cannabidiol’s
health
benefits
and
absence
of
serious
side
effects,
its
use
is
constantly
growing.
This
a
survey-based
cross-sectional
study
that
was
conducted
determine
Croatian
pharmacists’,
physicians’,
students’
knowledge
attitudes
about
cannabidiol
(CBD).
Two
questionnaires
were
created,
one
for
students
the
other
physicians
pharmacists.
Our
participants
(in
total
874:
473
401
pharmacists)
generally
had
positive
towards
CBD
therapy
as
approximately
60%
them
believe
treatment
efficacious.
Participants
toward
therapeutic
value
CBD,
especially
pharmacists
pharmacy
(63.8%
72.2%,
respectively).
Pharmacists
significantly
more
convinced
could
reduce
opioids
prescribed
chronic
pain
(p
<
0.05).
Only
17.5%
read
scientific
papers
compared
higher
percentage
(43.0%
47.8%,
respectively)
revealed
gap
in
regarding
since
89.3%
physicians,
well
84.8%
students,
they
need
education
CBD.
We
conclude
it
important
improve
educational
curricula
so
medical
professionals
can
recommend
their
patients
when
needed.
Язык: Английский