The Association Between Sarcopenia and Cardiovascular Disease: An Investigative Analysis from the NHANES

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 103864 - 103864

Опубликована: Янв. 1, 2025

Язык: Английский

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Characterisation of cardiovascular disease (CVD) incidence and machine learning risk prediction in middle-aged and elderly populations: data from the China health and retirement longitudinal study (CHARLS)

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 7, 2025

Due to the ageing population and evolving lifestyles occurring in China, middle-aged elderly populations have become high-risk groups for cardiovascular disease (CVD). The aim of this study was analyse incidence characteristics CVD these develop a prediction model by using data from China Health Retirement Longitudinal Study (CHARLS). We used follow-up CHARLS Chinese over time span 9 years. Five machine learning (ML) algorithms were employed risk prediction. Data preprocessing included missing value imputation via random forest. Feature selection performed Least Absolute Shrinkage Selection Operator (Lasso CV) method with cross-validation prior training. application synthetic minority over-sampling technique (SMOTE) address class imbalance. Model performance evaluated analyses including area under ROC curve (AUC), precision, recall, F1 score, SHAP plots interpretability. In accordance exclusion criteria, 12,580, 12,061, 11,545, 11,619 participants enrolled four rounds. cumulative (CI) at 2, 4, 7, years 2.846%, 8.971%, 17.869% 20.518%,, respectively. Significant differences observed across gender, age, ethnicity, region, higher rates females northeast region. Ultimately, 8,080 24 features analysed ML models built based on features. Although LGB achieves an AUC 0.818, indicating strong overall performance, its score recall rate are relatively low, 0.509 43.1%, Shapley additive explanations (SHAP) revealed importance key features, such as night sleep duration, TG levels, waist circumference, predicting outcomes, highlighted nonlinear relationships between risk. Gender, region significant factors influencing incidence. demonstrates good low reveal limitations identifying patients.

Язык: Английский

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Causal associations between the insulin-like growth factor family and sarcopenia: a bidirectional Mendelian randomization study

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Окт. 23, 2024

Objective Insulin-like growth factor (IGF) is closely associated with sarcopenia, yet the causal relationship of this association remains unclear. This study aims to explore potential between members IGF family and sarcopenia from a genetic perspective through bidirectional Mendelian randomization (MR) analysis using two-sample datasets. Methods Five genetically predicted factors (IGF-1, IGF-1R, IGF-2R, IGFBP-3, IGFBP-7) as one sample, while four relevant features (low hand grip strength, appendicular lean mass, whole body fat-free walking pace) another in conducting MR analysis. Results The forward results showed that elevated levels IGF-1 reduced risk low strength (OR = 0.936, 95% CI=0.892-0.983, P 0.008) increased mass extremities 1.125, CI=1.070-1.182,P 0.000; OR =1.076, CI=1.047-1.106, P=0.000), sarcopenia. Elevated IGF-1R also favored an increase (OR=1.023, CI=1.008-1.038, =0.002), trait was more pronounced IGFBP-3 IGFBP-7 (OR=1.034, CI=1.024-1.044, =0.000; OR=1.020, CI=1.010-1.030, P=0.000). Inverse effect on decreased may elevate (OR=1.243, CI=1.026-1.505,P =0.027), whereas improvements traits, pace (OR=0.902, CI: 0.877-0.927, OR=0.903, CI=0.859-0.949,P OR=0.209, CI=0.051-0.862,P 0.045). Also (OR=1.454, CI=1.108-1.909, =0.007), stimulated high expression IGFBP-1 (OR=1.314, CI=1.003-1.722, =0.047). Heterogeneity pleiotropy were not detected all results, stable reliable. Conclusion There bi-directional which provides adequate basis for early biological monitoring provide new targets intervention treatment

Язык: Английский

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Effects of sarcopenic obesity on incident chronic kidney disease and rapid kidney function decline: evidence from the China health and retirement longitudinal study

Postgraduate Medical Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Evidence on the effects of sarcopenic obesity (SO) incident chronic kidney disease (CKD) and rapid function decline (RKFD) in Chinese population is limited. This study aimed to prospectively examine associations SO with CKD RKFD among middle-aged older adults. prospective cohort utilized data from China Health Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal adults aged 45 older. The analysis included 4201 individuals 2011 wave, renal outcomes ascertained 2015 wave. were assessed using logistic regression models. Robustness was tested through subgroup sensitivity analyses. Over four years follow-up, 228 cases 213 observed. After multivariable adjustment, participants "sarcopenic obesity" group showed 78% increased risk (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.09-2.90) 79% (OR 1.79, CI 1.03-3.13), compared "nonsarcopenia without group. Consistent results observed across subgroups stratified by gender, education level, marital status, geographic area, lifestyle factors, comorbidities, no significant interactions detected. In population-based adults, independently associated elevated risks RKFD, interaction effects. These findings underscore importance timely intervention for prevent adverse outcomes. Key message What already known this topic? relationship between has been established Korean Japanese type 2 diabetes mellitus. However, it uncertain if these apply other populations, particularly those diabetes. Additionally, influence needs further exploration, link remains unestablished. regarding limited, highlighting necessity fill gaps knowledge. adds first explore association We identified as factor incidence both RKFD. expand understanding impact beyond mellitus, indicating that universal aging irrespective demographic health characteristics. How might affect research, practice, or policy identifies an independent suggest modifiable health, underscoring interventions Given rising prevalence populations worldwide, highlight incorporating management into public clinical strategies. Questions pending answer role do specific factors (e.g. diet, physical activity) play mitigating exacerbating SO? Are there genetic markers predispose higher RKFD? are underlying molecular mechanisms linking

Язык: Английский

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Association between sarcopenia and cardiovascular disease according to menopausal status: findings from the China Health and Retirement Longitudinal Study (CHARLS)

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 22, 2025

Little is known about the association between sarcopenia and cardiovascular disease (CVD) according to menopausal status, we conducted cross-sectional as well longitudinal analyses Using nationally representative data from China Health Retirement Longitudinal Study (CHARLS) investigate CVD in Chinese women status. The study sample included 5365 (mean age 60.3 ± 9.3 years) female participants CHARLS 2015 (wave 3). Additionally, 3,882 without were recruited (Wave 3) followed up 2018 4). was defined presence of physician-diagnosed heart and/or stroke. Menopausal status determined based on self-reported information questionnaires. Sarcopenia assessed using diagnostic criteria established by Asian Working Group 2019 (AWGS 2019). Binary logistic regression explore both premenopausal postmenopausal women. Further examined interaction better understand its impact CVD. prevalence total population 22.5% (1209/5365). Among women, no-sarcopenia, possible sarcopenia, group are 11.3% (86/759), 16.2% (17/105), 13.9% (5/36), respectively, for 19.2% (320/1668), 32.6% (520/1597), 21.8% (261/1200). Both (OR = 1.58; 95% CI: 1.29–1.93) 1.34; 1.05,1.72) associated with There a significant positive menopause CVD, RERI 5.30 (95%CI: 4.63, 5.98), SI 2.44 1.84, 3.63), multiplicative effect 2.18 1.70, 2.66). In analysis, 514 (13.2%) new cases diagnosed. significantly development 2.44, 1.3,4.59). 1.45, 1.28, 1.65) 1.42, 1.23, more likely have new-onset than no-sarcopenia risk show variations associations across different statuses, higher risks An found.

Язык: Английский

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Sarcopenia and Cardiovascular Diseases in Individuals With Diabetes or Prediabetes

Journal of Clinical Hypertension, Год журнала: 2025, Номер 27(3)

Опубликована: Фев. 28, 2025

ABSTRACT Sarcopenia is a known risk factor for cardiovascular disease (CVD) in individuals with diabetes or prediabetes, but the impact of changes sarcopenia status on CVD remains unclear. This study aimed to examine how between baseline and second follow‐up survey, conducted 2 years later, influence developing incident CVD. Incident was identified based self‐reported physician diagnoses heart disease, such as angina, myocardial infarction, failure, stroke. Cox proportional hazard models were used estimate ratios (HRs) 95% confidence intervals (CIs), adjusting potential confounders. The results showed that participants who progressed from non‐sarcopenia possible had higher Their significantly greater compared those remained non‐sarcopenic (HR 1.37, CI 1.08–1.73). Conversely, recovered lower than sarcopenic 0.40, 0.20–0.82). Among at baseline, reduced risk. reduction significant 0.62, 0.46–0.84). These findings suggest have risk, worsening increasing likelihood recovery lowering prediabetes.

Язык: Английский

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Short-Term Supplementation with 100% Bilberry Products and Its Effects on Body Composition and Lipid Profile in Overweight/Obese Women

Metabolites, Год журнала: 2025, Номер 15(4), С. 218 - 218

Опубликована: Март 24, 2025

Introduction: Overweight and obesity are major public health concerns, often leading to increased cardiovascular risk. Methods: This eight-week interventional study examined whether regular consumption of two natural bilberry products could improve body composition lipid profiles in overweight/obese women. A total 30 participants (aged 50–60 years) were assigned consume either 125 mL/day 100% juice or 10 g/day fibre, while maintaining their habitual diets lifestyles. Results: Although no significant changes found anthropometric parameters blood pressure group, both interventions reduced low-density lipoprotein cholesterol (LDL-C) high-density (HDL-C). Surprisingly, (TC) levels rose the group (from 6.41 ± 1.23 mmol/L 6.94 1.30 (p < 0.001)), fibre 6.06 1.39 6.43 1.05 = 0.046)), likely due elevated HDL-C 0.001) overshadowing drop LDL-C 0.05). Triglyceride (TG) did not change significantly still within reference range. Conclusions: Notably, experienced a reduction atherogenic small dense LDL (sdLDL) subfractions, suggesting favourable shift risk factors. These findings highlight potential bilberry-based as supportive strategy for improving

Язык: Английский

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The miRNomics of antiretroviral therapy-induced obesity

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 5, 2025

Язык: Английский

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Intelligent Predictive Risk Assessment and Management of Sarcopenia in Chronic Disease Patients Using Machine Learning and a Web-Based Tool

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Background: Individuals with chronic diseases are at higher risk of sarcopenia, and precise prediction is essential for its prevention. This study aims to develop a scoring model using longitudinal data predict the probability sarcopenia in this population over next 3 5 years, thereby enabling early warning intervention. Methods: Using from nationwide survey initiated 2011, we selected patient records wave 1 (2011–2012) follow-up (2015–2016) as cohort. Retrospective collection included demographic information, health conditions, biochemical markers. After excluding missing values, total 2,891 adults conditions were enrolled. Sarcopenia was assessed based on Asian Working Group (AWGS) 2019 guidelines. A generalized linear mixed (GLMM) random effects diverse machine learning models utilized explore feature contributions risk. The Recursive Feature Elimination (RFE) algorithm employed optimize full Multilayer Perceptron (MLP) an online application tool. Results: Among population, 580 (20.1%) individuals diagnosed (2011-2012), 638 (22.1%) (2015-2016), while 2,165 (74.9%) not across period. MLP model, performed better than other three classic models, demonstrated ROC AUC 0.912, PR 0.401, sensitivity 0.875, specificity 0.844, Kappa value 0.376, F1 score 0.44. According SHapley Additive exPlanations (SHAP) scoring, weight, age, BMI, height, cholesterol, PEF, gender identified most important features disease individualsfor sarcopenia. Using RFE algorithm, six key variables—weight, gender—achieving about 0.9 Conclusion: We developed that incorporates only easily accessible variables, diseases. Additionally, created practical tool assist decision-making streamline clinical assessments.

Язык: Английский

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Association Between the Serum Creatinine to Cystatin C Ratio and Cardiovascular Disease in Middle‐Aged and Older Adults in China: A Nationwide Cohort Study

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Background The relationship between the serum creatinine to cystatin C ratio (sarcopenia index [SI]) and risk of incident cardiovascular disease (CVD) remains unclear. Therefore, this study aims explore association SI CVD in middle‐aged older Chinese adults using nationally representative data. Methods Results We analyzed data from participants CHARLS (China Health Retirement Longitudinal Study) conducted 2015 2018. exposure variable was SI, calculated as C, multiplied by 100. outcome self‐reported (heart or stroke). A cross‐sectional analysis first performed data, which included 11 115 eligible (46.1% men; mean±SD age, 60.28±9.60 years). Logistic regression used estimate CVD. then 2018 follow‐up 8589 (46.4% 59.57±9.42 years), with a median period 3.0 years. Cox proportional hazard models were assess CVD, multivariate‐adjusted restricted cubic spline model dose–response relationship. In analysis, multivariate logistic revealed significant negative longitudinal identified 854 (9.94%) new cases. showed that lower significantly associated an increased incipient multivariable adjusted ratios for quartile 2 quartile4 groups compared those 1 group 0.94 (95% CI, 0.79–1.12), 0.63 0.51–0.78), 0.60 0.47–0.75), respectively. Restricted curves demonstrated linear incidence (all P ‐nonlinear>0.05). Conclusions new‐onset adults. This suggests has important potential application marker sarcopenia predicting

Язык: Английский

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