Association between serum iron status and gout: results from the NHANES and Mendelian randomization study
Food & Function,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Previous
observational
studies
have
provided
inconsistent
evidence
for
the
association
between
serum
iron
status
and
risk
of
gout.
Язык: Английский
Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990–2021)
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 27, 2025
Background
Gout,
caused
by
hyperuricemia
and
the
deposition
of
monosodium
urate
crystals
in
joints,
remains
a
major
global
health
issue.
Despite
progress
treatment,
its
prevalence
continues
to
rise,
contributing
comorbidities
like
cardiovascular
chronic
kidney
diseases.
Understanding
trends
sociodemographic
disparities
is
crucial
for
developing
targeted
interventions.
Methods
We
analyzed
gout
prevalence,
incidence,
disability-adjusted
life
years
(DALYs)
from
1990
2021,
stratified
age,
sex,
economic
development.
Decomposition
analysis
quantified
impact
demographic
factors,
while
advanced
assessed
relationship
between
burden
socioeconomic
Prediction
models
forecasted
future
trends,
cross-national
inequalities
were
evaluated
highlight
across
regions
with
different
development
levels.
Results
Between
increased
22,264,515
(95%
UI:
17,793,190–27,965,605)
56,474,572
45,161,987–70,288,316),
age-standardized
rate
(ASPR)
rising
536.54
653.82
per
100,000
population
[(Estimated
annual
percentage
changes)
EAPC:
0.87%,
95%
CI:
0.80–0.95].
The
incidence
cases
136.1%,
(ASIR)
17.12%
over
this
period.
Similarly,
death
(ASDR)
grew
21.30%,
accompanied
substantial
increase
DALYs.
revealed
that
aging
significantly
contributed
Middle
SDI
(36.79%),
growth
was
dominant
factor
Low
(98.58%).
Advanced
indicated
gaps
observed
optimal
levels
high-SDI
countries,
such
as
United
States
Australia,
highlighting
unrealized
opportunities
improving
outcomes.
projected
stable
2021
2045,
notable
gender-specific
age-specific
trends.
Cross-national
inequality
showed
worsening
DALYs
high-
low-SDI
regions,
reflected
increasing
Slope
Index
Inequality
Health
Concentration
values
2021.
Conclusion
has
risen,
facing
risks
lifestyle
changes
obesity,
struggle
healthcare
access.
Public
strategies
should
focus
on
modifiable
risk
infrastructure,
gender-
address
disparities.
Язык: Английский
Trace Element Deficiency in Axial Spondyloarthritis and Psoriatic Arthritis in Relation to Markers of Inflammation and Remission
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4924 - 4924
Опубликована: Май 21, 2025
Selenium
(Se)
is
an
essential
micronutrient
for
antioxidant
defense.
Selenoproteins
are
involved
in
metabolic
and
signaling
pathways
of
autoimmune
autoinflammatory
diseases.
Copper
(Cu)
zinc
(Zn)
integral
components
key
enzymes
regulatory
proteins.
Trace
element
(TE)
dysregulations
have
potential
relevance
as
disease
biomarkers.
In
this
study,
we
compare
TE
status
profiles
between
patients
with
axial
spondyloarthritis
(axSpA)
psoriatic
arthritis
(PsA),
relate
the
results
to
markers
inflammation,
remission,
healthy
controls.
Serum
was
measured
using
total
reflection
X-ray
fluorescence.
The
Se
transporter
SELENOP
extracellular
glutathione
peroxidase
(GPx3)
were
determined
by
ELISA
enzymatic
assay,
respectively.
Both
groups
(axSpA;
n
=
84,
PsA;
76)
displayed
deficiency
compared
European
adults.
Cu,
Se,
Zn,
SELENOP,
GPx3
levels
not
different
groups.
serum
Cu
Cu-Zn
ratio
correlated
positively
C-reactive
protein
(CRP)
erythrocyte
sedimentation
rate
(ESR).
An
inverse
correlation
CRP
observed
axSpA,
but
PsA.
On
average,
all
TE,
including
inflammation-responsive
levels,
below
reference
ranges,
indicating
a
both
Increasing
associated
low
suggesting
personalized
substitution
indicated
maintain
systemic
supply
protect
from
ferroptotic
cell
loss
under
inflammatory
conditions.
Язык: Английский