Nasal lymphatic obstruction of CSF drainage as a possible cause of Alzheimer’s disease and dementia DOI Creative Commons
William T. Phillips,

Joyce G. Schwartz

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Окт. 21, 2024

Alzheimer’s disease, the most common form of dementia among older adults, slowly destroys memory and thinking skills. In recent years, scientists have made tremendous progress in understanding still, they do not yet fully understand what causes disease. This article proposes a novel etiology for Our hypothesis developed from review nuclear medicine scans, which authors observed significant increase nasal turbinate vasodilation blood pooling patients with hypertension, sleep apnea, diabetes and/or obesity, all risk factors The propose that resultant lead to obstruction normal lymphatic clearance cerebrospinal fluid its waste products brain. vasodilation, due increased parasympathetic activity, occurs alongside well-established sympathetic activity cardiovascular system as seen hypertension. is likely an autonomic imbalance secondary worldwide consumption highly processed food associated dysregulation glucose regulatory system. authors’ offers mechanism new paradigm disease helps explain rapid rise other dementias are expected double next 20 years. provides compelling evidence modulation nervous treatment strategy degenerative brain diseases, specifically targeting flow.

Язык: Английский

Nasal lymphatic obstruction of CSF drainage as a possible cause of Alzheimer’s disease and dementia DOI Creative Commons
William T. Phillips,

Joyce G. Schwartz

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Окт. 21, 2024

Alzheimer’s disease, the most common form of dementia among older adults, slowly destroys memory and thinking skills. In recent years, scientists have made tremendous progress in understanding still, they do not yet fully understand what causes disease. This article proposes a novel etiology for Our hypothesis developed from review nuclear medicine scans, which authors observed significant increase nasal turbinate vasodilation blood pooling patients with hypertension, sleep apnea, diabetes and/or obesity, all risk factors The propose that resultant lead to obstruction normal lymphatic clearance cerebrospinal fluid its waste products brain. vasodilation, due increased parasympathetic activity, occurs alongside well-established sympathetic activity cardiovascular system as seen hypertension. is likely an autonomic imbalance secondary worldwide consumption highly processed food associated dysregulation glucose regulatory system. authors’ offers mechanism new paradigm disease helps explain rapid rise other dementias are expected double next 20 years. provides compelling evidence modulation nervous treatment strategy degenerative brain diseases, specifically targeting flow.

Язык: Английский

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