Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Flavonoids
are
naturally
occurring
dietary
phytochemicals
with
significant
antioxidant
effects
aside
from
several
health
benefits.
People
often
consume
them
in
combination
other
food
components.
Compiling
data
establishes
a
link
between
bioactive
flavonoids
and
prevention
of
diseases
animal
models,
including
cardiovascular
diseases,
diabetes,
gut
dysbiosis,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
However,
numerous
clinical
studies
have
demonstrated
the
ineffectiveness
contradicting
rodent
thereby
challenging
validity
using
as
supplements.
This
review
provides
perspective
to
emphasize
effective
roles
well
summarize
their
specific
mechanisms
animals
briefly.
First,
this
offers
an
in-depth
elucidation
processes
within
human,
encompassing
small,
large
intestine,
liver.
Furthermore,
comprehensive
overview
various
functions
gastrointestinal
tract,
hindering
breakdown
assimilation
macronutrients,
such
polysaccharides
lipids,
regulating
hormone
secretion
inhibition
mineral
iron
absorption.
In
unabsorbed
major
portion
interact
flora
leading
biotransformation.
Once
absorbed
circulated
bloodstream,
or
metabolites
exert
beneficial
systemic
effects.
Lastly,
we
examine
protective
disorders,
endothelial
dysfunction,
MASLD,
disease,
obesity,
hyperlipidemia,
insulin
resistance.
conclusion,
outlines
safety
future
prospects
field
health,
especially
syndrome
(MetS).
Язык: Английский
Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs
Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
the
most
common
chronic
and
is
closely
associated
with
metabolic
diseases
such
as
obesity,
type
2
diabetes
mellitus
(T2DM),
syndrome.
However,
effective
treatment
strategies
for
NAFLD
are
still
lacking.
In
recent
years,
progress
been
made
in
understanding
pathogenesis
of
NAFLD,
identifying
multiple
therapeutic
targets
providing
new
directions
drug
development.
This
review
summarizes
advances
focusing
on
mechanisms
action
natural
products,
small-synthetic-molecule
drugs,
combination
therapy
strategies.
aims
to
provide
insights
treating
NAFLD.
Язык: Английский
Flavonoids and Other Polyphenols: Bioactive Molecules from Traditional Medicine Recipes/Medicinal Plants and Their Potential for Phytopharmaceutical and Medical Application
Molecules,
Год журнала:
2024,
Номер
29(23), С. 5760 - 5760
Опубликована: Дек. 5, 2024
Currently,
natural
bioactive
ingredients
and/or
raw
materials
are
of
significant
interest
to
scientists
around
the
world.
Flavonoids
and
other
polyphenols
a
major
group
phytochemicals
that
have
been
researched
noted
as
molecules.
They
offer
several
pharmacological
medical
benefits.
This
current
review
aims
(1)
illustrate
their
benefits
for
human
health,
such
antioxidant,
anti-aging,
anti-cancer,
anti-inflammatory,
anti-microbial,
cardioprotective,
neuroprotective,
UV-protective
effects,
also
(2)
perform
quality
evaluation
traditional
medicines
future
application.
Consequently,
keywords
were
searched
on
Scopus,
Google
Scholar,
PubMed
so
search
related
publications.
Then,
those
publications
carefully
checked
in
order
find
non-redundant
studies
matched
objective
this
review.
According
review,
researchers
worldwide
very
interested
discovering
potential
flavonoids
polyphenols,
used
taken
from
medicinal
plants,
relation
pharmaceutical
applications.
Many
focus
health
tested
using
silico,
vitro,
vivo
models.
However,
few
carried
out
clinical
trials
trustworthy
subject
sizes
accordance
with
practice
guidelines.
Additionally,
interesting
research
directions
perspectives
highlighted
work.
Язык: Английский
The Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation for the Management of Obesity and Non-Alcoholic Fatty Liver Disease: Recent Updates
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 206 - 206
Опубликована: Янв. 15, 2025
Epigallocatechin
gallate
(EGCG)
is
the
predominant
bioactive
catechin
in
green
tea,
and
it
has
been
ascribed
a
range
of
beneficial
health
effects.
Current
increases
obesity
non-alcoholic
fatty
liver
disease
(NAFLD)
rates
represent
persistent
burdensome
threat
to
global
public
health.
While
many
clinical
studies
have
demonstrated
that
EGCG
associated
with
positive
effects
on
various
parameters,
including
metabolic
biomarkers,
waist
circumference,
body
weight
when
consumed
by
individuals
affected
NAFLD,
there
are
also
some
reports
suggesting
may
entail
degree
hepatotoxicity.
The
present
review
provides
comprehensive
summary
extant
findings
pertaining
safety
effectiveness
managing
particular
focus
how
treatment
duration
dose
level
affect
bioactivity
this
compound.
Язык: Английский
Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 956 - 956
Опубликована: Март 9, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
considered
a
significant
global
health
issue
related
to
serious
metabolic
disorders.
However,
effective
pharmacological
treatments
are
still
limited.
Flavonoids,
wide
group
of
polyphenol
substances,
exert
anti-inflammatory
and
lipid-lowering
effects
in
preclinical
data.
Thus,
implementing
these
research
findings
clinical
practice
could
significantly
help
manage
NAFLD
its
consequences.
This
narrative
review
assesses
the
therapeutic
potential
flavonoids
managing
NAFLD.
The
collected
randomized
controlled
trials
(RCTs)
meta-analyses
RCTs
from
past
five
years
concerning
impact
on
A
total
20
studies
were
selected
according
predetermined
inclusion
criteria,
comprising
thirteen
seven
meta-analyses.
underscores
beneficial
management
through
enhancement
lipid
metabolism,
reduction
hepatic
steatosis,
provision
actions.
Clinical
demonstrate
that
interventions
rich
flavonoids,
including
quercetin,
epigallocatechin
gallate,
naringenin,
isoflavones,
substantially
reduce
fat
content
enhance
enzyme
profiles,
with
certain
compounds
exhibiting
superior
efficacy
particular
subgroups,
such
as
older
adults
females.
Nonetheless,
whereas
therapies
diminish
their
effect
fibrosis
constrained.
To
sum
up,
exhibit
supplementary
for
by
enhancing
function,
inflammation.
Additional
extensive
necessary
create
uniform
treatment
methods
ascertain
long-term
advantages.
Язык: Английский
Addressing the alarming link between nonalcoholic fatty liver disease and cardiovascular mortality in men
World Journal of Cardiology,
Год журнала:
2024,
Номер
16(9), С. 502 - 507
Опубликована: Сен. 19, 2024
This
editorial
discusses
the
key
findings
presented
in
Batta
and
Hatwal’s
recent
paper
titled
“Excess
cardiovascular
mortality
men
with
non-alcoholic
fatty
liver
disease:
A
cause
for
concern!”,
which
was
published
World
Journal
of
Cardiology
.
Their
original
article
highlights
a
notable
correlation
between
nonalcoholic
disease
(NAFLD)
increased
risk
men.
The
present
commentary
explores
implications
their
findings,
discussing
potential
mechanisms,
factors,
urgent
need
integrated
clinical
approaches
to
mitigate
dual
burden
these
diseases.
Emphasis
should
be
placed
on
importance
early
detection,
lifestyle
modifications,
interdisciplinary
collaboration
improving
patient
outcomes.
aims
highlight
broad
NAFLD
health
advocate
awareness
proactive
management
strategies
within
medical
community.
Язык: Английский