Soybean 7S Protein/Calcium Phosphate Complexes for Enhanced Probiotic Delivery and Gut Microbial Regulation
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106383 - 106383
Опубликована: Март 1, 2025
Язык: Английский
The Gut–Heart Axis and Its Role in Doxorubicin-Induced Cardiotoxicity: A Narrative Review
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 855 - 855
Опубликована: Апрель 9, 2025
Doxorubicin
is
a
widely
used
chemotherapy
for
the
treatment
of
several
types
cancer.
However,
its
application
restricted
due
to
adverse
effects,
particularly
cardiotoxicity,
which
can
progress
heart
failure—a
chronic
and
debilitating
condition.
Several
mechanisms
have
been
identified
in
pathophysiology
doxorubicin-induced
including
oxidative
stress,
mitochondrial
dysfunction,
inflammation,
disruption
collagen
homeostasis.
More
recently,
dysbiosis
gut
microbiota
has
implicated
development
perpetuation
cardiac
injury.
Studies
reported
alterations
composition
abundance
during
doxorubicin
treatment.
Therefore,
as
recent,
there
new
field
research
order
develop
strategies
involving
prevent
or
attenuate
cardiotoxicity
since
no
effective
therapy
at
moment.
This
narrative
review
aims
provide
an
update
on
role
intestinal
permeability
cardiovascular
diseases,
more
specifically
cardiotoxicity.
Additionally,
it
seeks
establish
foundation
future
targeting
alleviate
Язык: Английский
The Role of the Gut Microbiota in Heart Failure: Pathophysiological Insights and Future Perspectives
Medicina,
Год журнала:
2025,
Номер
61(4), С. 720 - 720
Опубликована: Апрель 14, 2025
The
gut
microbiota
has
emerged
as
a
crucial
player
in
cardiovascular
diseases,
including
heart
failure
(HF).
Recent
studies
have
highlighted
the
bidirectional
interaction
between
and
heart,
often
referred
to
gut–heart
axis.
Dysbiosis,
characterized
by
alterations
microbial
composition
function,
been
linked
systemic
inflammation,
metabolic
disturbances,
impaired
homeostasis.
This
review
explores
mechanisms
through
which
influences
HF,
metabolite
production,
inflammatory
pathways,
endothelial
dysfunction,
hormonal
modulation,
fluid
retention,
sodium
absorption.
potential
therapeutic
implications
of
modulation
diet,
probiotics,
pharmacological
interventions
are
also
discussed.
Understanding
these
could
pave
way
for
novel
diagnostic
strategies
management
HF.
Future
research
should
focus
on
longitudinal
establish
causality
development
personalized
microbiota-based
interventions.
Язык: Английский
Gut Microbiota Metabolites and Chronic Diseases: Interactions, Mechanisms, and Therapeutic Strategies
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3752 - 3752
Опубликована: Апрель 16, 2025
The
gut
microbiota,
shaped
by
factors
such
as
diet,
lifestyle,
and
genetics,
plays
a
pivotal
role
in
regulating
host
metabolism,
immune
function,
overall
health.
diversity
balance
of
the
microbiota
are
closely
linked
to
onset
progression
various
chronic
diseases.
A
growing
body
evidence
has
demonstrated
that
alterations
composition,
metabolites
significantly
associated
with
cardiovascular
diseases,
including
hypertension,
atherosclerosis,
heart
failure;
metabolic
disorders
obesity,
type
2
diabetes,
dysfunction-associated
steatotic
liver
disease;
gastrointestinal
conditions
like
inflammatory
bowel
disease
colorectal
cancer.
Despite
substantial
advances
microbiome
research,
challenges
remain
fully
elucidating
causal
relationships
between
disease,
well
translating
these
insights
into
clinical
applications.
This
review
aims
investigate
regulatory
pathways
via
which
affects
health,
disease.
Additionally,
it
highlights
emerging
strategies
for
prevention
treatment
conditions,
focusing
on
microbiota-targeted
therapies
personalized
dietary
interventions
promising
approaches
improving
health
outcomes.
Язык: Английский