ACS Nano,
Год журнала:
2021,
Номер
15(4), С. 7179 - 7194
Опубликована: Апрель 16, 2021
Flexible
manipulation
of
the
fate
cancer
cells
through
exogenous
stimulation-induced
metabolic
reprogramming
could
handle
cellular
plasticity-derived
therapies
resistance,
which
provides
an
effective
paradigm
for
treatment
refractory
and
relapsing
tumors
in
clinical
settings.
Herein,
we
demonstrated
that
moderate
heat
(45
°C)
significantly
regress
expression
antioxidants
trigger
specific
lipid
synergized
with
iron
oxide
nanoparticles
(Fe3O4
NPs).
This
control
behavior
destroyed
tumor
redox
homeostasis
produced
overwhelming
peroxides,
consequently
sensitizing
to
ferroptosis.
Based
on
these
findings,
a
heat-triggered
tumor-specific
ferroptosis
strategy
was
proposed
by
rational
design
polypeptide-modified
1H-perfluoropentane
(1H-PFP)-encapsulated
Fe3O4-containing
nanoformulation
(GBP@Fe3O4).
When
irradiated
808
nm
laser,
phase
transition
1H-PFP
triggered
localized
°C),
leading
burst
release
Fe3O4
situ
produce
potent
reactive
oxygen
species
Fenton
reaction
microenvironment.
Together
antioxidant
inhibition
response
distinctive
stress,
this
oxidative
damage
amplified
induce
achieve
sufficient
antitumor
effects.
Importantly,
confirmed
ACSBG1,
acyl-CoA
synthetase,
key
pro-ferroptotic
factor
heat-induced
process.
Moreover,
knockout
gene
realize
cell
death
conversion
from
non-ferroptotic
death.
work
mechanistic
insights
practical
strategies
reduce
potential
side
effects
direct
inducers
highlights
regulating
under
stress.
Metabolism
as
cancer
progresses
Numerous
cancer-specific
alterations
in
metabolism
have
been
identified
but
not
yet
resulted
an
effective
anti
therapeutic.
In
a
Review,
Faubert
et
al.
discuss
how
changes
develops
from
small,
premalignant
lesion
to
aggressive
primary
tumor
and
then
metastasizes.
Metabolic
vulnerabilities
likely
change
with
progression,
making
the
identification
of
general
cancer-associated
metabolic
features
difficult.
The
authors
propose
that
more
targeted
approach
tissues
patients
may
be
effective.
Science
,
this
issue
p.
eaaw5473
A
paradox
of
tumor
immunology
is
that
tumor-infiltrating
lymphocytes
are
dysfunctional
in
situ,
yet
capable
stem
cell-like
behavior
including
self-renewal,
expansion,
and
multipotency,
resulting
the
eradication
large
metastatic
tumors.
We
find
overabundance
potassium
microenvironment
underlies
this
dichotomy,
triggering
suppression
T
cell
effector
function
while
preserving
stemness.
High
levels
extracellular
constrain
programs
by
limiting
nutrient
uptake,
thereby
inducing
autophagy
reduction
histone
acetylation
at
exhaustion
loci,
which
turn
produces
CD8+
cells
with
improved
vivo
persistence,
clearance.
This
mechanistic
knowledge
advances
our
understanding
dysfunction
may
lead
to
novel
approaches
enable
development
enhanced
strategies
for
cancer
immunotherapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 13, 2023
Abstract
Infection
susceptibility,
poor
vaccination
efficacy,
age-related
disease
onset,
and
neoplasms
are
linked
to
innate
adaptive
immune
dysfunction
that
accompanies
aging
(known
as
immunosenescence).
During
aging,
organisms
tend
develop
a
characteristic
inflammatory
state
expresses
high
levels
of
pro-inflammatory
markers,
termed
inflammaging.
This
chronic
inflammation
is
typical
phenomenon
immunosenescence
it
considered
the
major
risk
factor
for
diseases.
Thymic
involution,
naïve/memory
cell
ratio
imbalance,
dysregulated
metabolism,
epigenetic
alterations
striking
features
immunosenescence.
Disturbed
T-cell
pools
antigen
stimulation
mediate
premature
senescence
cells,
senescent
cells
proinflammatory
senescence-associated
secretory
phenotype
exacerbates
Although
underlying
molecular
mechanisms
remain
be
addressed,
well
documented
T
inflammaging
might
driving
forces
in
Potential
counteractive
measures
will
discussed,
including
intervention
cellular
metabolic-epigenetic
axes
mitigate
In
recent
years,
has
attracted
increasing
attention
its
role
tumor
development.
As
result
limited
participation
elderly
patients,
impact
on
cancer
immunotherapy
unclear.
Despite
some
surprising
results
from
clinical
trials
drugs,
necessary
investigate
other
Frontiers in Immunology,
Год журнала:
2020,
Номер
10
Опубликована: Янв. 20, 2020
Natural
killer
(NK)
cells
are
a
population
of
innate
lymphoid
playing
pivotal
role
in
host
immune
responses
against
infection
and
tumor
growth.
These
have
powerful
cytotoxic
activity
orchestrated
by
an
intricate
network
inhibitory
activating
signals.
The
importance
NK
controlling
growth
mediating
robust
anti-metastatic
effect
has
been
demonstrated
different
experimental
mouse
cancer
models.
Consistently,
high
density
tumor-infiltrating
linked
with
good
prognosis
multiple
human
solid
tumors.
However,
there
also
tumors
that
appear
to
be
refractory
cell-mediated
killing
for
the
presence
immunosuppressive
microenvironment
affecting
cell
function.
Immunotherapeutic
strategies
aimed
at
restoring
increasing
tumors,
including
adoptive
transfer
CAR-NK
cells,
currently
employed
preclinical
clinical
studies.
In
this
review,
we
outline
recent
advances
supporting
direct
expansion
their
prognostic
value
cancers.
We
summarize
mechanisms
adopted
affect
function,
finally
evaluate
current
augment
antitumor
function
treatment
Frontiers in Cell and Developmental Biology,
Год журнала:
2020,
Номер
8
Опубликована: Фев. 11, 2020
Tumor
immunotherapy
is
a
promising
therapeutic
strategy
for
patients
with
advanced
cancers.
T
cells
are
key
mediators
of
antitumor
function
that
specifically
recognize
and
react
to
tumor-expressing
antigens
have
proven
critical
cancer
immunotherapy.
However,
not
as
effective
against
expected.
This
partly
because
enter
dysfunctional
or
exhausted
state,
which
characterized
by
sustained
expression
inhibitory
receptors
transcriptional
state
distinct
from
functional
effector
memory
cells.
cell
dysfunction
induces
the
out
control
tumors.
Recently,
has
been
investigated
in
many
experimental
clinical
settings.
The
molecular
definition
underlying
causes
regardless
fact
pathways
involved
well
elucidated,
proposing
opportunities
clinic.
In
this
review,
we
will
discuss
recent
advances
mechanisms
affect
TME
induce
dysfunction,
development
immunotherapies
counteract
tumor-induced
dysfunction.
Better
understanding
these
may
lead
new
strategies
improve
outcome
cancer.
Abstract
Pancreatic
cancer
is
currently
one
of
the
most
lethal
diseases.
In
recent
years,
increasing
evidence
has
shown
that
reprogrammed
metabolism
may
play
a
critical
role
in
carcinogenesis,
progression,
treatment
and
prognosis
pancreatic
cancer.
Affected
by
internal
or
external
factors,
cells
adopt
extensively
distinct
metabolic
processes
to
meet
their
demand
for
growth.
Rewired
glucose,
amino
acid
lipid
crosstalk
within
tumor
microenvironment
contribute
unlimited
progression.
addition,
reprogramming
involved
resistance
also
closely
related
chemotherapy,
radiotherapy
immunotherapy,
results
poor
prognosis.
Reflective
key
metabolism,
number
preclinical
clinical
trials
about
metabolism-targeted
therapies
increasing.
The
patients
might
be
largely
improved
after
employing
regulate
metabolism.
Thus,
investigations
not
only
benefit
understanding
carcinogenesis
progression
but
provide
new
insights
treatments
against
