Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Cell Metabolism, Год журнала: 2019, Номер 31(1), С. 92 - 104.e5

Опубликована: Дек. 5, 2019

Язык: Английский

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Genomics of circadian rhythms in health and disease

Genome Medicine, Год журнала: 2019, Номер 11(1)

Опубликована: Дек. 1, 2019

Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts over myriad aspects of mammalian physiology, including the regulation sleep, metabolism, immune system. Here, we review advances in understanding genetic sleep through system, as well impact dysregulated gene expression on metabolic function. We also recent studies have begun to unravel clock’s role controlling cardiovascular nervous systems, gut microbiota, cancer, aging. Such these systems relies, part, transcriptional regulation, with evidence for genome-wide chromosome organization. These novel insights into genomic human physiology provide opportunities discovery improved treatment strategies new biological underpinnings disease.

Язык: Английский

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Hallmarks of Health

Cell, Год журнала: 2020, Номер 184(1), С. 33 - 63

Опубликована: Дек. 18, 2020

Язык: Английский

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Clocks, cancer, and chronochemotherapy

Science, Год журнала: 2020, Номер 371(6524)

Опубликована: Дек. 31, 2020

Doubts in cancer-rhythms connections Circadian clocks help to coordinate physiological processes with the daily cycles of light and dark periods feeding, activity, rest. Being out sync such 24-hour can have unhealthy effects. Sancar Van Gelder review available evidence regarding circadian disruption predisposition cancer variations response chemotherapy. The literature be difficult interpret. For example, complete knockouts clock genes are not same as shift work. Overall, they find that jury is still on whether promote general if timing treatment optimized. However, enough indications present further research recommended. Science , this issue p. 42

Язык: Английский

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Circadian rhythms and disorders of the timing of sleep

The Lancet, Год журнала: 2022, Номер 400(10357), С. 1061 - 1078

Опубликована: Сен. 1, 2022

Язык: Английский

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Molecular mechanism of the repressive phase of the mammalian circadian clock

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 118(2)

Опубликована: Дек. 23, 2020

Significance The circadian clock mechanism is a daily rhythmic activation of gene transcription by the CLOCK–BMAL1 heterodimer and repression CRYs (CRY1 CRY2) PERs (PER1 PER2). are highly expressed around predawn, when they begin repressing cry per other genes, leading to nadir in afternoon. CRY represses simply binding on DNA, PER removing from DNA CRY-dependent manner. This work shows that removal involves phosphorylation CLOCK, which accomplished CK1δ deliver complex nucleus.

Язык: Английский

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Top Priorities for Cerebroprotective Studies—A Paradigm Shift: Report From STAIR XI

Stroke, Год журнала: 2021, Номер 52(9), С. 3063 - 3071

Опубликована: Июль 22, 2021

Despite years of basic research and pioneering clinical work, ischemic stroke remains a major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) conferences identified both failures trial design in preclinical assessment developing putative treatments. At XI, participants workshop no. 1 Top Priorities for Neuroprotection sought to redefine the neuroprotection paradigm given paucity evidence underlying assessment, offer consensus-based recommendations. proposes term brain cytoprotection or cerebroprotection replace when intention an investigation is demonstrate that new, candidate treatment benefits entire brain. Although “time still brain,” tissue imaging techniques have been developed identify patients with predicted core injury penumbral, salvageable tissue, regardless time after symptom onset. XI called this approach window select recanalization. Elements neurovascular unit show differential vulnerability evolving over differing scales different regions. target suggest therapies elements at times. Based on contemporary principles rigor transparency, updated, revised, enhanced recommendations new treatments 2 phases: exploratory qualification phase definitive validation phase. For treatments, investigators should carefully characterize mechanism action, pharmacokinetics/pharmacodynamics, engagement, confirm penetration through blood-brain barrier. Before trials, testing molecules models could proceed comprehensive manner using animals sexes include significant variables such as age comorbid conditions. Comprehensive might multicenter, collaborative testing, example, network trials. In absence proven cerebroprotective agent use gold standard, however, it speculative whether can effectively predict outcome.

Язык: Английский

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Chronobiology and Chronomedicine

Royal Society of Chemistry eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 23, 2024

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for difference between life death response identical stimulus. The partly endogenous nature of circadian has well documented methods their characterisation developed enabling cellular molecular mechanisms understood. Chronobiology Chronomedicine aims provide a review these underlying illustrate role brain’s suprachiasmatic nuclei ‘pace-making’ process effects caused by ‘clock genes’ present almost all cells. Beyond involved, book discusses relationship body systems, disease, proper function; particular, how disruption rhythm is associated with ill health disease status from observations made at organismic level. organised an ideal introduction postgraduate various fields, reviewing developments outlining show depth breadth chronobiology chronomedicine, as invaluable companion researchers healthcare professionals working field interest developing novel therapeutic approaches.

Язык: Английский

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Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

Science, Год журнала: 2023, Номер 379(6631), С. 478 - 483

Опубликована: Фев. 2, 2023

The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age sex is not defined in humans. We combined data from Genotype-Tissue Expression (GTEx) project with an algorithm that assigns phases to 914 donors, by integrating temporal information multiple tissues each individual, identify messenger RNA (mRNA) 46 tissues. Clock transcripts showed conserved timing relationships tight synchrony across body. mRNA varied breadth, covering global functions, including metabolic pathways systemic responses. structure was sexes groups. overall were highly sex-dimorphic more sustained females. Rhythmic programs generally dampened

Язык: Английский

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Foundations of circadian medicine

PLoS Biology, Год журнала: 2022, Номер 20(3), С. e3001567 - e3001567

Опубликована: Март 24, 2022

The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption rhythms associated with many common pathologies. emerging field medicine aims exploit mechanisms clock–disease interaction for clinical diagnosis, treatment, prevention. In this Essay, we outline principle approaches medicine, highlight development in selected areas, point out open questions challenges. Circadian has unambiguous health benefits over standard care but rarely utilized. It biology become integrated part translational research.

Язык: Английский

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