Cancer and Metastasis Reviews,
Год журнала:
2022,
Номер
41(3), С. 517 - 547
Опубликована: Сен. 1, 2022
Abstract
Obesity
is
an
established
risk
factor
for
several
human
cancers.
Given
the
association
between
excess
body
weight
and
cancer,
increasing
rates
of
obesity
worldwide
are
worrisome.
A
variety
obesity-related
factors
has
been
implicated
in
cancer
initiation,
progression,
response
to
therapy.
These
include
circulating
nutritional
factors,
hormones,
cytokines,
causing
hyperinsulinemia,
inflammation,
adipose
tissue
dysfunction.
The
impact
these
conditions
on
development
progression
focus
extensive
literature.
In
this
review,
we
concentrate
processes
that
can
link
which
provide
a
novel
perspective:
extracellular
matrix
remodeling,
angiogenesis,
adrenergic
signaling.
We
describe
molecular
mechanisms
involved
processes,
represent
putative
targets
intervention.
Liver,
pancreas,
breast
cancers
were
chosen
as
exemplary
disease
models.
view
expanding
epidemic
obesity,
better
understanding
tumorigenic
process
obese
individuals
might
lead
more
effective
treatments
preventive
measures.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5238 - 5238
Опубликована: Май 11, 2024
Currently,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
steatohepatitis
(MASH)
are
considered
to
be
the
main
causes
of
fibrosis.
In
turn,
fibrosis
may
lead
development
hepatocellular
carcinoma
or
advanced
cirrhosis,
i.e.,
potentially
life-threatening
conditions.
It
is
likely
that
therapy
aimed
at
reducing
risk
developing
hepatic
steatosis
inflammation
could
helpful
in
minimizing
threat/probability
organ
recent
years,
increasing
attention
has
been
paid
influence
nutraceuticals
prevention
treatment
diseases.
Therefore,
aim
this
review
was
describe
precise
role
selected
ingredients
such
as
vitamin
C,
beta-carotene,
omega-3
fatty
acids,
curcumin.
use
these
patients
with
MASLD/MASH,
along
behavioral
pharmacological
therapy,
have
a
beneficial
effect
on
combating
inflammation,
oxidative
stress,
thereby
preventing
damage.
Cell Reports,
Год журнала:
2022,
Номер
39(3), С. 110697 - 110697
Опубликована: Апрель 1, 2022
The
glucocorticoid
receptor
(GR)
is
a
nuclear
critical
to
the
regulation
of
energy
metabolism
and
inflammation.
actions
GR
are
dependent
on
cell
type
context.
Here,
we
demonstrate
role
liver
lineage-determining
factor
hepatocyte
4A
(HNF4A)
in
defining
specificity
action.
In
mouse
liver,
HNF4A
motif
lies
adjacent
response
element
(GRE)
at
binding
sites
within
regions
open
chromatin.
absence
HNF4A,
cistrome
remodeled,
with
loss
gain
recruitment
evident.
Loss
chromatin
accessibility
HNF4A-marked
associates
weak
GRE
motifs.
gained
characterized
by
strong
motifs,
which
show
non-liver
tissues.
functional
importance
these
HNF4A-regulated
indicated
an
altered
transcriptional
treatment
Hnf4a-null
liver.
Cancer and Metastasis Reviews,
Год журнала:
2022,
Номер
41(3), С. 517 - 547
Опубликована: Сен. 1, 2022
Abstract
Obesity
is
an
established
risk
factor
for
several
human
cancers.
Given
the
association
between
excess
body
weight
and
cancer,
increasing
rates
of
obesity
worldwide
are
worrisome.
A
variety
obesity-related
factors
has
been
implicated
in
cancer
initiation,
progression,
response
to
therapy.
These
include
circulating
nutritional
factors,
hormones,
cytokines,
causing
hyperinsulinemia,
inflammation,
adipose
tissue
dysfunction.
The
impact
these
conditions
on
development
progression
focus
extensive
literature.
In
this
review,
we
concentrate
processes
that
can
link
which
provide
a
novel
perspective:
extracellular
matrix
remodeling,
angiogenesis,
adrenergic
signaling.
We
describe
molecular
mechanisms
involved
processes,
represent
putative
targets
intervention.
Liver,
pancreas,
breast
cancers
were
chosen
as
exemplary
disease
models.
view
expanding
epidemic
obesity,
better
understanding
tumorigenic
process
obese
individuals
might
lead
more
effective
treatments
preventive
measures.
